Distribution of histopathologic variant patterns in NLPHL cases
| . | Minor component† . | ||||||
|---|---|---|---|---|---|---|---|
| Major component* . | A . | B . | C . | D . | E . | F . | Total‡ . |
| A | 294 (71%) | — | 10 (2%) | 24 (6%) | 1 (0%) | 3 (1%) | 332 (80%) |
| B | 2 (0%) | 12 (3%) | 1 (0%) | 3 (1%) | — | — | 18 (4%) |
| C | 5 (1%) | 1 (0%) | 15 (4%) | 3 (1%) | 3 (1%) | — | 27 (7%) |
| D | 7 (2%) | 1 (0%) | — | 3 (1%) | 7 (2%) | 3 (1%) | 21 (5%) |
| E | — | — | 1 (0%) | 5 (1%) | — | 1 (0%) | 7 (2%) |
| F | — | — | 1 (0%) | — | — | 7 (2%) | 8 (2%) |
| Total | 308 (75%) | 14 (3%) | 28 (7%) | 38 (9%) | 11 (3%) | 14 (3%) | 413 (100%) |
| . | Minor component† . | ||||||
|---|---|---|---|---|---|---|---|
| Major component* . | A . | B . | C . | D . | E . | F . | Total‡ . |
| A | 294 (71%) | — | 10 (2%) | 24 (6%) | 1 (0%) | 3 (1%) | 332 (80%) |
| B | 2 (0%) | 12 (3%) | 1 (0%) | 3 (1%) | — | — | 18 (4%) |
| C | 5 (1%) | 1 (0%) | 15 (4%) | 3 (1%) | 3 (1%) | — | 27 (7%) |
| D | 7 (2%) | 1 (0%) | — | 3 (1%) | 7 (2%) | 3 (1%) | 21 (5%) |
| E | — | — | 1 (0%) | 5 (1%) | — | 1 (0%) | 7 (2%) |
| F | — | — | 1 (0%) | — | — | 7 (2%) | 8 (2%) |
| Total | 308 (75%) | 14 (3%) | 28 (7%) | 38 (9%) | 11 (3%) | 14 (3%) | 413 (100%) |
Cases with a single growth pattern are bolded.
Pattern A: “Classic” nodular pattern, B cell–rich; pattern B: serpiginous/interconnected nodular pattern; pattern C: nodular with prominent extranodular LP cells; pattern D: nodular with T cell–rich background; pattern E: diffuse pattern (T cell/histiocyte–rich large B-cell lymphoma–like); pattern F: diffuse, “moth-eaten,” with B cell–rich background
Major component: Dominating histopathologic growth (found in >50% of lymphoma tissue).
Minor component: Histopathologic growth pattern observed in <50% of the lymphoma tissue.
Ten cases with tumor cell–rich histology are excluded.