Differentially expressed genes in EBV-positive ABC DLBCL vs EBV-negative ABC DLBCL
| Gene functional categories . | No. of genes . | Representative genes . |
|---|---|---|
| Genes upregulated in EBV-positive ABC-DLBCL | ||
| NF-κB target | 11 | PRDM1, CYLD, FYN, TNFAIP3, FTH1, LITAF |
| Cell cycle regulation | 4 | CYTIP, PPM1A, TMEM30A, MRPL41 |
| Antiapoptosis | 4 | MDM2, DNAJC5, SERPINB9, GSTO1 |
| Tumor progression | 5 | LAMP1, PTP4A2, DYNLRB1, ASAP1, ERLEC1 |
| Cell proliferation | 3 | TXN, PDXK, GLUL |
| Cell adhesion and cytoskeleton | 6 | GABARAP, WIPF, AOC3, DST, SLAMF7, C1orf38 |
| Intracellular trafficking | 4 | TMED2, RAB27A, M6PR, FLOT1 |
| Immune response | 2 | SAMHD1, GBP2 |
| Cell metabolism | 12 | GPD2, P4HB, GNS, RPN2, APOL6, LASS6 |
| Transcription factors | 2 | ARNTL, TLE3 |
| Others and unknown | 17 | RPN2, SLC31A1, M6PR, SETD3, KIAA2013, TPCN2 |
| Genes downregulated in EBV-positive ABC-DLBCL | ||
| Proapopototic | 2 | TBX5, CUL3 |
| Immune response | 2 | ENPP3, CD79B |
| Cell metabolism | 3 | GATM, MOCOS, GALNT6 |
| Extracellular matrix, adhesion, cytoskeleton | 10 | CDHR1, CDHR3, CDH11, TRIP6, CLDN10, SMAGP |
| Signaling and transcription factors | 3 | CHN2, STYXL1, SPIB |
| Others and unknown | 49 | SPINK5, MYO3A, PHF14, LRRC39, MAGEB3, MGP |
| Gene functional categories . | No. of genes . | Representative genes . |
|---|---|---|
| Genes upregulated in EBV-positive ABC-DLBCL | ||
| NF-κB target | 11 | PRDM1, CYLD, FYN, TNFAIP3, FTH1, LITAF |
| Cell cycle regulation | 4 | CYTIP, PPM1A, TMEM30A, MRPL41 |
| Antiapoptosis | 4 | MDM2, DNAJC5, SERPINB9, GSTO1 |
| Tumor progression | 5 | LAMP1, PTP4A2, DYNLRB1, ASAP1, ERLEC1 |
| Cell proliferation | 3 | TXN, PDXK, GLUL |
| Cell adhesion and cytoskeleton | 6 | GABARAP, WIPF, AOC3, DST, SLAMF7, C1orf38 |
| Intracellular trafficking | 4 | TMED2, RAB27A, M6PR, FLOT1 |
| Immune response | 2 | SAMHD1, GBP2 |
| Cell metabolism | 12 | GPD2, P4HB, GNS, RPN2, APOL6, LASS6 |
| Transcription factors | 2 | ARNTL, TLE3 |
| Others and unknown | 17 | RPN2, SLC31A1, M6PR, SETD3, KIAA2013, TPCN2 |
| Genes downregulated in EBV-positive ABC-DLBCL | ||
| Proapopototic | 2 | TBX5, CUL3 |
| Immune response | 2 | ENPP3, CD79B |
| Cell metabolism | 3 | GATM, MOCOS, GALNT6 |
| Extracellular matrix, adhesion, cytoskeleton | 10 | CDHR1, CDHR3, CDH11, TRIP6, CLDN10, SMAGP |
| Signaling and transcription factors | 3 | CHN2, STYXL1, SPIB |
| Others and unknown | 49 | SPINK5, MYO3A, PHF14, LRRC39, MAGEB3, MGP |