Modulatory factors with putative penultimate (alanine/proline) truncation site for DPP4
| Modulatory Factors . | |||||
|---|---|---|---|---|---|
| Peptide . | Species . | N-terminus*† . | Peptide . | Species . | N-terminus*† . |
| Adipsin (propeptide) | H | PPRGR... | IGF-1 isoform 4 | M | GPETL... |
| Adipsin (propeptide) | M | QPRGR... | IGF-1 isoform 5 | M | GPETL... |
| α-1 microglobulin | H | GPVPT... | Inhibin α chain (propeptide) | H | HALGG... |
| α-1 microglobulin | M | DPAST... | Inhibin α chain (propeptide) | M | HAVGG... |
| ANGPTL4 (isoform a) | H | GPVQS... | Inhibin β E chain | H | TPTCE... |
| ANGPTL4 (isoform b) | H | GPVQS... | Inhibin β E chain | M | TPTCE... |
| ANGPTL6 | H | RAGAP... | Lactoferrin | M | KATTV... |
| BDNF (propeptide) | H | APMKE... | Leptin | H | VPIQK... |
| BDNF (propeptide) | M | APMKE... | Leptin | M | VPIQK... |
| bFGF | H | PALPE... | LIF | H | SPLPI... |
| bFGF | M | PALPE... | LIF | M | SPLPI... |
| Bradykinin | H | RPPGF... | LTα | H | LPGVG... |
| Bradykinin | M | RPPGF... | Neurotrophin-3 | H | YAEHK... |
| BMP-4 | H | SPKHH... | Neurotrophin-3 | M | YAEHK... |
| BMP-4 | M | SPKHH... | Notch-3 | H | APPCL... |
| BMP-5 | H | AANKR... | Notch-3 | M | APPCL... |
| BMP-5 | M | AASKR... | NPY | H | YPSKP... |
| c1qTNF5 | H | SPPLD... | NPY | M | YPSKP... |
| c1qTNF5 | M | SPPLD... | Oncostatin M | H | AAIGS... |
| Chromogranin | H | LPVNS... | Osteopontin | H | IPVKQ... |
| Chromogranin | M | LPVNS... | Osteopontin | M | LPVKV... |
| DKK3 | H | APAPT... | PDGFD | M | TPQRA... |
| DNER | H | NPVPA... | Peptide YY | H | YPIKP... |
| Enterostatin | H | APGPR... | Peptide YY | M | YPAKP... |
| Enterostatin | M | APGPR... | Prolactin | H | LPICP... |
| GDF-1 | H | DAEPV... | Prolactin | M | LPICS... |
| GDF-3 | H | AAIPV... | RBP3 | H | GPTHL... |
| GDF-3 | M | AAISV... | RBP3 | M | GPTHL... |
| GDF-5 | H | APLAT... | Somatotropin isoform 1 | H | FPTIP... |
| GDF-5 | M | APLAN... | Somatotropin isoform 2 | H | FPTIP... |
| GDF-6 | H | TAFAS... | Somatotropin isoform 3 | H | FPTIP... |
| GDF-6 | M | TAFAS... | Somatotropin isoform 4 | H | FPTIP... |
| GDF-7 | H | TALAG... | Somatotropin | M | FPAMP... |
| GDF-7 | M | TALAG... | Transferrin | H | VPDKT... |
| GDF-8 | H | GPVDL...§ | Transferrin | M | VPDKT... |
| GDNF (propeptide) | H | SPDKQ... | Trypsinogen | H | APFDD... |
| GDNF (propeptide) | M | SPDKQ... | Vasostatin-1 | H | LPVNS... |
| GHRH | H | YADAI... | Vasostatin-2 | H | LPVNS... |
| GLP-1 (7-36) | H | HAEGT... | VEGF A isoform i | H | APMAE... |
| GLP-2 | H | HADGS... | VEGF A isoform k | H | APMAE... |
| GRP | H | VPLPA... | VEGF A isoform l | H | APMAE... |
| GRP | M | APVST... | VEGF A isoform m | H | APMAE... |
| HCG α | H | APDVQ... | VEGF A isoform n | H | APMAE... |
| HCG α | M | LPDGD... | VEGF A isoform o | H | APMAE... |
| IGF-1 isoform 1 | H | GPETL... | VEGF A isoform p | H | APMAE... |
| IGF-1 isoform 2 | H | GPETL... | VEGF A isoform 1 | M | APTTE... |
| IGF-1 isoform 3 | H | GPETL... | VEGF A isoform 2 | M | APTTE... |
| IGF-1 isoform 4 | H | GPETL... | VEGF A isoform 3 | M | APTTE... |
| IGF-1 isoform 1 | M | GPETL... | Wnt 9b | M | AAYFG... |
| IGF-1 isoform 2 | M | GPETL... | Wnt 10a | H | MPRSA... |
| IGF-1 isoform 3 | M | GPETL... | Wnt 10a | M | VPRSA... |
| Modulatory Factors . | |||||
|---|---|---|---|---|---|
| Peptide . | Species . | N-terminus*† . | Peptide . | Species . | N-terminus*† . |
| Adipsin (propeptide) | H | PPRGR... | IGF-1 isoform 4 | M | GPETL... |
| Adipsin (propeptide) | M | QPRGR... | IGF-1 isoform 5 | M | GPETL... |
| α-1 microglobulin | H | GPVPT... | Inhibin α chain (propeptide) | H | HALGG... |
| α-1 microglobulin | M | DPAST... | Inhibin α chain (propeptide) | M | HAVGG... |
| ANGPTL4 (isoform a) | H | GPVQS... | Inhibin β E chain | H | TPTCE... |
| ANGPTL4 (isoform b) | H | GPVQS... | Inhibin β E chain | M | TPTCE... |
| ANGPTL6 | H | RAGAP... | Lactoferrin | M | KATTV... |
| BDNF (propeptide) | H | APMKE... | Leptin | H | VPIQK... |
| BDNF (propeptide) | M | APMKE... | Leptin | M | VPIQK... |
| bFGF | H | PALPE... | LIF | H | SPLPI... |
| bFGF | M | PALPE... | LIF | M | SPLPI... |
| Bradykinin | H | RPPGF... | LTα | H | LPGVG... |
| Bradykinin | M | RPPGF... | Neurotrophin-3 | H | YAEHK... |
| BMP-4 | H | SPKHH... | Neurotrophin-3 | M | YAEHK... |
| BMP-4 | M | SPKHH... | Notch-3 | H | APPCL... |
| BMP-5 | H | AANKR... | Notch-3 | M | APPCL... |
| BMP-5 | M | AASKR... | NPY | H | YPSKP... |
| c1qTNF5 | H | SPPLD... | NPY | M | YPSKP... |
| c1qTNF5 | M | SPPLD... | Oncostatin M | H | AAIGS... |
| Chromogranin | H | LPVNS... | Osteopontin | H | IPVKQ... |
| Chromogranin | M | LPVNS... | Osteopontin | M | LPVKV... |
| DKK3 | H | APAPT... | PDGFD | M | TPQRA... |
| DNER | H | NPVPA... | Peptide YY | H | YPIKP... |
| Enterostatin | H | APGPR... | Peptide YY | M | YPAKP... |
| Enterostatin | M | APGPR... | Prolactin | H | LPICP... |
| GDF-1 | H | DAEPV... | Prolactin | M | LPICS... |
| GDF-3 | H | AAIPV... | RBP3 | H | GPTHL... |
| GDF-3 | M | AAISV... | RBP3 | M | GPTHL... |
| GDF-5 | H | APLAT... | Somatotropin isoform 1 | H | FPTIP... |
| GDF-5 | M | APLAN... | Somatotropin isoform 2 | H | FPTIP... |
| GDF-6 | H | TAFAS... | Somatotropin isoform 3 | H | FPTIP... |
| GDF-6 | M | TAFAS... | Somatotropin isoform 4 | H | FPTIP... |
| GDF-7 | H | TALAG... | Somatotropin | M | FPAMP... |
| GDF-7 | M | TALAG... | Transferrin | H | VPDKT... |
| GDF-8 | H | GPVDL...§ | Transferrin | M | VPDKT... |
| GDNF (propeptide) | H | SPDKQ... | Trypsinogen | H | APFDD... |
| GDNF (propeptide) | M | SPDKQ... | Vasostatin-1 | H | LPVNS... |
| GHRH | H | YADAI... | Vasostatin-2 | H | LPVNS... |
| GLP-1 (7-36) | H | HAEGT... | VEGF A isoform i | H | APMAE... |
| GLP-2 | H | HADGS... | VEGF A isoform k | H | APMAE... |
| GRP | H | VPLPA... | VEGF A isoform l | H | APMAE... |
| GRP | M | APVST... | VEGF A isoform m | H | APMAE... |
| HCG α | H | APDVQ... | VEGF A isoform n | H | APMAE... |
| HCG α | M | LPDGD... | VEGF A isoform o | H | APMAE... |
| IGF-1 isoform 1 | H | GPETL... | VEGF A isoform p | H | APMAE... |
| IGF-1 isoform 2 | H | GPETL... | VEGF A isoform 1 | M | APTTE... |
| IGF-1 isoform 3 | H | GPETL... | VEGF A isoform 2 | M | APTTE... |
| IGF-1 isoform 4 | H | GPETL... | VEGF A isoform 3 | M | APTTE... |
| IGF-1 isoform 1 | M | GPETL... | Wnt 9b | M | AAYFG... |
| IGF-1 isoform 2 | M | GPETL... | Wnt 10a | H | MPRSA... |
| IGF-1 isoform 3 | M | GPETL... | Wnt 10a | M | VPRSA... |
ANGPTL, angiopoietin-related protein; BDNF, brain-derived neurotrophic factor; bFGF, basis fibroblast growth factor; BMP, bone morphogenetic protein; c1qTNF5, C1q and tumor necrosis factor related protein 5; DKK, Dickkopf-related protein; DNER, Δ and notchlike epidermal growth factor–related receptor; GDF, growth differentiation factor; GDNF, glial cell line–derived neurotrophic factor; GHRH, growth-hormone–releasing hormone; GLP, glucagonlike peptide; GRP, gastrin-releasing peptide; HCG α, glycoprotein hormones α chain; IGF, insulin-like growth factor; LIF, leukemia inhibitory factor; LTα, lymphotoxin-α; Notch, neurogenic locus notch homolog protein; NPY, neuropeptide Y; PDGFD, platelet-derived growth factor D; RBP, retinol-binding protein; VEGF, vascular endothelial growth factor. Species: M = mouse, H = human.
Sequence retrieved from NCBI database.
Sequence retrieved from UniProt.
Sequence only retrieved from NCBI database.