Subanalysis of single mismatched transplantations after multivariate modeling
| Locus . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Matched | 1511 | 1.00 | ||
| A-allele-MM | 61 | 1.44 | 1.02-2.04 | .039 |
| A-antigen-MM | 121 | 1.31 | 1.00-1.72 | .047 |
| B-allele-MM | 76 | 1.53 | 1.11-2.09 | .009 |
| B-antigen-MM | 30 | 1.79 | 1.13-2.83 | .014 |
| C-allele-MM | 67 | 1.10 | 0.78-1.56 | .600 |
| C-antigen-MM | 300 | 1.27 | 1.06-1.53 | .009 |
| DR-allele-MM | 46 | 1.17 | 0.75-1.82 | .500 |
| DR-antigen-MM | 7 | NA | NA | NA |
| DQ-allele-MM | 54 | 0.76 | 0.48-1.21 | .250 |
| DQ-antigen-MM | 41 | 1.42 | 0.93-2.17 | .100 |
| DFS | ||||
| Matched | 1511 | 1.00 | ||
| A-allele-MM | 61 | 1.25 | 0.90-1.76 | .190 |
| A-antigen-MM | 121 | 1.16 | 0.89-1.50 | .270 |
| B-allele-MM | 76 | 1.33 | 0.98-1.81 | .067 |
| B-antigen-MM | 30 | 1.39 | 0.88-2.21 | .160 |
| C-allele-MM | 67 | 1.12 | 0.81-1.55 | .480 |
| C-antigen-MM | 300 | 1.25 | 1.05-1.48 | .012 |
| DR-allele-MM | 46 | 1.14 | 0.75-1.72 | .550 |
| DR-antigen-MM | 7 | NA | NA | NA |
| DQ-allele-MM | 54 | 0.79 | 0.52-1.20 | .260 |
| DQ-antigen-MM | 41 | 1.32 | 0.88-1.97 | .180 |
| TRM | ||||
| Matched | 1509 | 1.00 | ||
| A-allele-MM | 61 | 1.33 | 0.80-2.23 | .280 |
| A-antigen-MM | 121 | 1.53 | 1.07-2.20 | .021 |
| B-allele-MM | 76 | 1.66 | 1.10-2.52 | .017 |
| B-antigen-MM | 30 | 1.60 | 0.85-2.99 | .140 |
| C-allele-MM | 67 | 1.34 | 0.85-2.12 | .210 |
| C-antigen-MM | 300 | 1.29 | 0.99-1.69 | .064 |
| DR-allele-MM | 46 | 1.53 | 0.86-2.73 | .150 |
| DR-antigen-MM | 7 | NA | NA | NA |
| DQ-allele-MM | 54 | 1.03 | 0.59-1.81 | .910 |
| DQ-antigen-MM | 41 | 1.16 | 0.57-2.40 | .680 |
| Locus . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| OS | ||||
| Matched | 1511 | 1.00 | ||
| A-allele-MM | 61 | 1.44 | 1.02-2.04 | .039 |
| A-antigen-MM | 121 | 1.31 | 1.00-1.72 | .047 |
| B-allele-MM | 76 | 1.53 | 1.11-2.09 | .009 |
| B-antigen-MM | 30 | 1.79 | 1.13-2.83 | .014 |
| C-allele-MM | 67 | 1.10 | 0.78-1.56 | .600 |
| C-antigen-MM | 300 | 1.27 | 1.06-1.53 | .009 |
| DR-allele-MM | 46 | 1.17 | 0.75-1.82 | .500 |
| DR-antigen-MM | 7 | NA | NA | NA |
| DQ-allele-MM | 54 | 0.76 | 0.48-1.21 | .250 |
| DQ-antigen-MM | 41 | 1.42 | 0.93-2.17 | .100 |
| DFS | ||||
| Matched | 1511 | 1.00 | ||
| A-allele-MM | 61 | 1.25 | 0.90-1.76 | .190 |
| A-antigen-MM | 121 | 1.16 | 0.89-1.50 | .270 |
| B-allele-MM | 76 | 1.33 | 0.98-1.81 | .067 |
| B-antigen-MM | 30 | 1.39 | 0.88-2.21 | .160 |
| C-allele-MM | 67 | 1.12 | 0.81-1.55 | .480 |
| C-antigen-MM | 300 | 1.25 | 1.05-1.48 | .012 |
| DR-allele-MM | 46 | 1.14 | 0.75-1.72 | .550 |
| DR-antigen-MM | 7 | NA | NA | NA |
| DQ-allele-MM | 54 | 0.79 | 0.52-1.20 | .260 |
| DQ-antigen-MM | 41 | 1.32 | 0.88-1.97 | .180 |
| TRM | ||||
| Matched | 1509 | 1.00 | ||
| A-allele-MM | 61 | 1.33 | 0.80-2.23 | .280 |
| A-antigen-MM | 121 | 1.53 | 1.07-2.20 | .021 |
| B-allele-MM | 76 | 1.66 | 1.10-2.52 | .017 |
| B-antigen-MM | 30 | 1.60 | 0.85-2.99 | .140 |
| C-allele-MM | 67 | 1.34 | 0.85-2.12 | .210 |
| C-antigen-MM | 300 | 1.29 | 0.99-1.69 | .064 |
| DR-allele-MM | 46 | 1.53 | 0.86-2.73 | .150 |
| DR-antigen-MM | 7 | NA | NA | NA |
| DQ-allele-MM | 54 | 1.03 | 0.59-1.81 | .910 |
| DQ-antigen-MM | 41 | 1.16 | 0.57-2.40 | .680 |
Impact of single allele or antigen HLA MMs per locus on OS, DFS, and TRM. Significance level set to P < .01. Cases with more than one HLA mismatch were excluded from this analysis. Significant results are bold.
NA, number too low for analysis.