Table 2 Associations with hepcidin pre-... | American Society of Hematology

Table 2

Associations with hepcidin pre- and posttransfusion

Variable	Pretransfusion				Posttransfusion
Variable	Coefficient [95% CI]	β coefficient	P	R²	Coefficient [95% CI]	β Coefficient	P	R²
Univariate regression
Age	−0.02 [−0.07, 0.03]	−0.14	.461	0.02	−0.01 [−0.06, 0.04]	−0.09	.654	0.01
Gender	−0.99 [−1.69, −0.30]	−0.48	.007	0.23	−1.30 [−2.01, −0.59]	−0.61	.001	0.37
Hb	0.05 [0.01, 0.08]	0.47	.009	0.21	0.05 [0.02, 0.08]	0.60	.001	0.36
Ferritin	0.70 [0.30, 1.11]	0.56	.001	0.32	0.64 [0.08, 1.20]	0.44	.026	0.19
CRP	0.01 [−0.53, 0.56]	0.01	.963	0.00	0.22 [−0.32, 0.77]	0.17	.404	0.03
EPO	−0.67 [−1.17, −0.17]	−0.48	.010	0.23	−1.35 [−1.93, −0.78]	−0.71	<.001	0.51
GDF-15	−0.97 [−1.51, −0.42]	−0.56	.001	0.32	−1.17 [−1.75, −0.59]	−0.65	<.001	0.42
sTfR	−1.18 [−2.16, −0.20]	−0.43	.020	0.18	−1.58 [−2.75, −0.42]	−0.50	.010	0.25
Multiple regression
Model 1
Gender	−0.66 [−1.26, −0.07]	−0.32	.031	0.57	−0.75 [−1.47, −0.03]	−0.35	.041	0.57
Ferritin	0.49 [0.13, 0.86]	0.40	.010		0.34 [−0.12, 0.80]	0.23	.144
Hb	0.04 [0.02, 0.07]	0.43	.003		0.04 [0.01, 0.06]	0.43	.010
Model 2
Gender	−0.46 [−1.09, 0.17]	−0.23	.146	0.53	−0.66 [−1.31, −0.02]	−0.31	.045	0.68
Ferritin	0.58 [0.17, 0.98]	0.43	.007		0.36 [−0.08, 0.79]	0.23	.102
EPO	−0.59 [−1.00, −0.18]	−0.42	.007		−1.01 [−1.53, −0.49]	0.56	.001
Model 3
Gender	−0.12 [−0.82, 0.58]	−0.06	.731	0.54	−0.31 [−1.19, 0.57]	−0.15	.475	0.58
Ferritin	0.58 [0.21, 0.96]	0.47	.004		0.50 [0.02, 0.97]	0.34	.041
GDF-15	−0.76 [−1.30, −0.21]	−0.45	.008		−0.96 [−1.65, −0.27]	−0.53	.009
Model 4
Gender	−0.28 [−1.01, 0.45]	−0.14	.437	0.47	−0.75 [−1.55, 0.05]	−0.35	.066	0.51
Ferritin	0.60 [0.19, 1.00]	0.48	.006		0.43 [−0.07, 0.93]	0.29	.089
sTfR	−0.89 [−1.80, 0.03]	−0.32	.057		−1.11 [−2.21, −0.01]	−0.35	.049

Variable	Pretransfusion				Posttransfusion
Variable	Coefficient [95% CI]	β coefficient	P	R²	Coefficient [95% CI]	β Coefficient	P	R²
Univariate regression
Age	−0.02 [−0.07, 0.03]	−0.14	.461	0.02	−0.01 [−0.06, 0.04]	−0.09	.654	0.01
Gender	−0.99 [−1.69, −0.30]	−0.48	.007	0.23	−1.30 [−2.01, −0.59]	−0.61	.001	0.37
Hb	0.05 [0.01, 0.08]	0.47	.009	0.21	0.05 [0.02, 0.08]	0.60	.001	0.36
Ferritin	0.70 [0.30, 1.11]	0.56	.001	0.32	0.64 [0.08, 1.20]	0.44	.026	0.19
CRP	0.01 [−0.53, 0.56]	0.01	.963	0.00	0.22 [−0.32, 0.77]	0.17	.404	0.03
EPO	−0.67 [−1.17, −0.17]	−0.48	.010	0.23	−1.35 [−1.93, −0.78]	−0.71	<.001	0.51
GDF-15	−0.97 [−1.51, −0.42]	−0.56	.001	0.32	−1.17 [−1.75, −0.59]	−0.65	<.001	0.42
sTfR	−1.18 [−2.16, −0.20]	−0.43	.020	0.18	−1.58 [−2.75, −0.42]	−0.50	.010	0.25
Multiple regression
Model 1
Gender	−0.66 [−1.26, −0.07]	−0.32	.031	0.57	−0.75 [−1.47, −0.03]	−0.35	.041	0.57
Ferritin	0.49 [0.13, 0.86]	0.40	.010		0.34 [−0.12, 0.80]	0.23	.144
Hb	0.04 [0.02, 0.07]	0.43	.003		0.04 [0.01, 0.06]	0.43	.010
Model 2
Gender	−0.46 [−1.09, 0.17]	−0.23	.146	0.53	−0.66 [−1.31, −0.02]	−0.31	.045	0.68
Ferritin	0.58 [0.17, 0.98]	0.43	.007		0.36 [−0.08, 0.79]	0.23	.102
EPO	−0.59 [−1.00, −0.18]	−0.42	.007		−1.01 [−1.53, −0.49]	0.56	.001
Model 3
Gender	−0.12 [−0.82, 0.58]	−0.06	.731	0.54	−0.31 [−1.19, 0.57]	−0.15	.475	0.58
Ferritin	0.58 [0.21, 0.96]	0.47	.004		0.50 [0.02, 0.97]	0.34	.041
GDF-15	−0.76 [−1.30, −0.21]	−0.45	.008		−0.96 [−1.65, −0.27]	−0.53	.009
Model 4
Gender	−0.28 [−1.01, 0.45]	−0.14	.437	0.47	−0.75 [−1.55, 0.05]	−0.35	.066	0.51
Ferritin	0.60 [0.19, 1.00]	0.48	.006		0.43 [−0.07, 0.93]	0.29	.089
sTfR	−0.89 [−1.80, 0.03]	−0.32	.057		−1.11 [−2.21, −0.01]	−0.35	.049

Hepcidin, sTfR, ferritin, EPO, and CRP all log-transformed following addition of 1. Gender coded: female = 0; male = 1. β-coefficient, coefficient using variables standardized to have variance of 1.

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