Family-based association test results
| . | . | . | Type 1 VWD . | VWF:RCo . | VWF:Ag . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Markers . | Allele . | Allele frequency . | Family (no.) . | Z score . | P value . | Family (no.) . | Z score . | P value . | Family (no.) . | Z score . | P value . |
| VNTR | 5 | 0.286 | 53 | 1.85 | .064 | 56 | 1.07 | .29 | 56 | 0.84 | .40 |
| 6 | 0.143 | 40 | −2.59 | .0096 | 42 | −2.19 | .029 | 42 | −1.72 | .085 | |
| 7 | 0.531 | 63 | 0.13 | .90 | 65 | 0.32 | .75 | 65 | 0.28 | .78 | |
| rs868875 | G nt | 0.300 | 46 | 1.52 | .13 | 50 | 0.15 | .88 | 50 | 0.15 | .88 |
| . | . | . | Type 1 VWD . | VWF:RCo . | VWF:Ag . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Markers . | Allele . | Allele frequency . | Family (no.) . | Z score . | P value . | Family (no.) . | Z score . | P value . | Family (no.) . | Z score . | P value . |
| VNTR | 5 | 0.286 | 53 | 1.85 | .064 | 56 | 1.07 | .29 | 56 | 0.84 | .40 |
| 6 | 0.143 | 40 | −2.59 | .0096 | 42 | −2.19 | .029 | 42 | −1.72 | .085 | |
| 7 | 0.531 | 63 | 0.13 | .90 | 65 | 0.32 | .75 | 65 | 0.28 | .78 | |
| rs868875 | G nt | 0.300 | 46 | 1.52 | .13 | 50 | 0.15 | .88 | 50 | 0.15 | .88 |
Association analysis of discrete and continuous outcomes (n = 177 families) was performed using an additive genetic model and empiric variance model.
The z score is a standard score. When considering the binary trait, VWD, a positive score indicates excess transmission of that allele to affected individuals, and a negative score indicates a paucity of transmission of that allele to affected individuals. When considering the quantitative traits, VWF:RCo and VWF:Ag, a negative score indicates an association of that allele with higher levels of the trait in question.