Consequences of intravascular hemolysis in the mechanisms of thrombosis in PNH
| 1. Release of free hemoglobin resulting in: |
| a. Platelet activation |
| b. Thrombophlebitis |
| c. NO depletion with consequences of: |
| i. Vasoconstriction |
| ii. Platelet activation and aggregation |
| iii. Increased expression of cellular adhesion molecules |
| iv. Secretion of procoagulant proteins |
| v. Ischemia-reperfusion injury |
| vi. Endothelial proliferation |
| vii. Increased inflammatory markers |
| viii. Factor XIII activation |
| ix. Increased levels of thrombin-antithrombin complexes and fibrin split products |
| d. Inhibition of ADAMTS13 |
| e. Direct endothelial dysfunction |
| f. Activation of endothelial cells and release of microparticles |
| g. Increased levels of tissue factor |
| h. Increased levels of reactive oxygen species |
| 2. Release of arginase resulting in NO depletion |
| 3. Release of procoagulant red cell microparticles |
| 1. Release of free hemoglobin resulting in: |
| a. Platelet activation |
| b. Thrombophlebitis |
| c. NO depletion with consequences of: |
| i. Vasoconstriction |
| ii. Platelet activation and aggregation |
| iii. Increased expression of cellular adhesion molecules |
| iv. Secretion of procoagulant proteins |
| v. Ischemia-reperfusion injury |
| vi. Endothelial proliferation |
| vii. Increased inflammatory markers |
| viii. Factor XIII activation |
| ix. Increased levels of thrombin-antithrombin complexes and fibrin split products |
| d. Inhibition of ADAMTS13 |
| e. Direct endothelial dysfunction |
| f. Activation of endothelial cells and release of microparticles |
| g. Increased levels of tissue factor |
| h. Increased levels of reactive oxygen species |
| 2. Release of arginase resulting in NO depletion |
| 3. Release of procoagulant red cell microparticles |