Blood clotting parameters
| Assay . | vehicle . | ALX-0081 (5 mg/kg) . | rtPA Low dose . | ALX-0081+rtPA . |
|---|---|---|---|---|
| Activated partial thromboplastin time (sec) | 31.5 ± 11.9 | 31.8 ± 4.4 | 35.9 ± 7.2 | 33.0 ± 6.3 |
| Prothrombin time (sec) | 30.9 ± 1.1 | 32.7 ± 5.1 | 31.5 ± 4.6 | 32.1 ± 3.7 |
| Fibrinogen level (mg/dl) | 108.5 ± 12.9 | ND | 119.5 ± 15.7 | 121.3 ± 13.7 |
| VWF Ag (%) | ||||
| Time (min) | ||||
| 0 (Baseline) | 35.0 ± 4.7 | |||
| 5 | 30.0 ± 0.96 | |||
| 30 | 33.4 ± 9.4 | |||
| 60 | 38.9 ± 9.9 | |||
| 1440 | 41.8 ± 2.6 |
| Assay . | vehicle . | ALX-0081 (5 mg/kg) . | rtPA Low dose . | ALX-0081+rtPA . |
|---|---|---|---|---|
| Activated partial thromboplastin time (sec) | 31.5 ± 11.9 | 31.8 ± 4.4 | 35.9 ± 7.2 | 33.0 ± 6.3 |
| Prothrombin time (sec) | 30.9 ± 1.1 | 32.7 ± 5.1 | 31.5 ± 4.6 | 32.1 ± 3.7 |
| Fibrinogen level (mg/dl) | 108.5 ± 12.9 | ND | 119.5 ± 15.7 | 121.3 ± 13.7 |
| VWF Ag (%) | ||||
| Time (min) | ||||
| 0 (Baseline) | 35.0 ± 4.7 | |||
| 5 | 30.0 ± 0.96 | |||
| 30 | 33.4 ± 9.4 | |||
| 60 | 38.9 ± 9.9 | |||
| 1440 | 41.8 ± 2.6 |
Data represents means ± SD (n=5).
ND, not determined.