Table 1 Clinical characteristics of... | American Society of Hematology

Table 1

Clinical characteristics of exome-sequenced T-LGL leukemia patients and patients with STAT5b mutation

No.	LGL leukemia type	Mutations	Sex	Age at diagnosis, y	WBC count at diagnosis, 10⁹/L	Lymph count at diagnosis, 10⁹/L	Lymphocyte count, 10⁹/L*	CD8⁺ Vβ †	Concomitant disorders	Therapy‡
1	CD3⁺CD8⁺CD56⁺ T cell	STAT5b Y665F	F	71	11.8	7.0	8.5	Vb22, 91%	Collagenosis	No
2	CD3⁺CD8⁺CD56⁺ T cell	STAT5b Y665F	F	49	16.1	12.9	13.7	Vb17, 94%	None	No
3	CD3⁺CD8⁺CD56⁺ T cell	STAT5b N642H	M	74	90.0	85.5	85.5	Vb21, 87%§	Pancytopenia, neutropenia, splenomegaly	Yes
4	CD3^negCD56⁺ NK cell	STAT5b N642H	M	75	164.7	131.8	131.8	Vb7, 27%§Vb3, 16%§	Hemolytic anemia, neutropenia, splenomegaly, MGUS	Yes

No.	LGL leukemia type	Mutations	Sex	Age at diagnosis, y	WBC count at diagnosis, 10⁹/L	Lymph count at diagnosis, 10⁹/L	Lymphocyte count, 10⁹/L*	CD8⁺ Vβ †	Concomitant disorders	Therapy‡
1	CD3⁺CD8⁺CD56⁺ T cell	STAT5b Y665F	F	71	11.8	7.0	8.5	Vb22, 91%	Collagenosis	No
2	CD3⁺CD8⁺CD56⁺ T cell	STAT5b Y665F	F	49	16.1	12.9	13.7	Vb17, 94%	None	No
3	CD3⁺CD8⁺CD56⁺ T cell	STAT5b N642H	M	74	90.0	85.5	85.5	Vb21, 87%§	Pancytopenia, neutropenia, splenomegaly	Yes
4	CD3^negCD56⁺ NK cell	STAT5b N642H	M	75	164.7	131.8	131.8	Vb7, 27%§Vb3, 16%§	Hemolytic anemia, neutropenia, splenomegaly, MGUS	Yes

F, female; M, male; MGUS, monoclonal gammapathy of unknown significance; WBC, white blood cell.

Lymphocyte count at the time point when the sample was taken.

Proportion of Vβ clone of CD8⁺ cells.

Pharmacological treatment at any time point.

Proportion from total T-cell fraction.