Risk of CVD in patients with provoked and unprovoked VT
| Subjects . | Individuals, n . | Observation-years . | Events, n . | Incidence rate per 1000 py (95% CI) . | Adjusted HR* (95% CI) . | Adjusted HR† (95% CI) . | Adjusted HR‡ (95% CI) . |
|---|---|---|---|---|---|---|---|
| RDD controls | 2638 | 10 166 | 16 | 1.6 (0.9-2.6) | Reference | Reference | Reference |
| Patients with unprovoked VT | 2006 | 10 022 | 36 | 3.6 (2.5-5.0) | 2.6 (1.4-4.9) | 1.8 (0.9-3.7) | 1.8 (0.9-3.6) |
| Patients with VT provoked by: | 2474 | 12 401 | 36 | 2.9 (2.0-4.0) | 2.0 (1.1-3.9) | 2.7 (1.3-5.6) | 2.6 (1.2-5.4) |
| OC or HRT use§ | 1258 | 6960 | 9 | 1.3 (0.6-2.5) | 1.3 (0.5-3.6) | 4.0 (1.1-14.9) | 3.9 (1.1-14.4) |
| Pregnancy‖ | 163 | 935 | 0 | NA | NA | NA | NA |
| Surgery‖ | 731 | 3716 | 18 | 4.8 (2.9-7.7) | 3.5 (1.6-7.4) | 2.8 (1.2-6.4) | 2.5 (1.1-6.0) |
| Hospitalization‖ | 798 | 3890 | 13 | 3.3 (1.8-5.7) | 2.3 (1.0-5.4) | 2.2 (0.9-5.4) | 1.9 (0.7-4.8) |
| Malignancy¶ | 422 | 1255 | 8 | 6.4 (2.8-12.6) | 4.3 (1.6-12.1) | 2.1 (0.7-7.0) | 2.0 (0.6-6.7) |
| Partner controls | 2926 | 16 402 | 36 | 2.2 (1.5-3.0) | Reference | Reference | Reference |
| Patients with unprovoked VT | 2006 | 10 022 | 36 | 3.6 (2.5-5.0) | 1.7 (1.1-2.8) | 1.4 (0.9-2.4) | 1.5 (0.9-2.5) |
| Patients with VT provoked by: | 2474 | 12 401 | 36 | 2.9 (2.0-4.0) | 1.4 (0.9-2.2) | 1.8 (1.0-3.0) | 1.7 (1.0-2.9) |
| OC or HRT use§ | 1258 | 6960 | 9 | 1.3 (0.6-2.5) | 0.7 (0.3-1.6) | 1.1 (0.4-3.2) | 1.2 (0.4-3.4) |
| Pregnancy‖ | 163 | 935 | 0 | NA | NA | NA | NA |
| Surgery‖ | 731 | 3716 | 18 | 4.8 (2.9-7.7) | 2.3 (1.3-4.2) | 2.2 (1.2-4.2) | 2.0 (1.0-3.9) |
| Hospitalization‖ | 798 | 3890 | 13 | 3.3 (1.8-5.7) | 1.6 (0.8-3.1) | 1.6 (0.8-3.4) | 1.5 (0.7-3.1) |
| Malignancy¶ | 422 | 1255 | 8 | 6.4 (2.8-12.6) | 3.3 (1.5-7.5) | 2.1 (0.8-5.1) | 2.1 (0.8-5.1) |
| Subjects . | Individuals, n . | Observation-years . | Events, n . | Incidence rate per 1000 py (95% CI) . | Adjusted HR* (95% CI) . | Adjusted HR† (95% CI) . | Adjusted HR‡ (95% CI) . |
|---|---|---|---|---|---|---|---|
| RDD controls | 2638 | 10 166 | 16 | 1.6 (0.9-2.6) | Reference | Reference | Reference |
| Patients with unprovoked VT | 2006 | 10 022 | 36 | 3.6 (2.5-5.0) | 2.6 (1.4-4.9) | 1.8 (0.9-3.7) | 1.8 (0.9-3.6) |
| Patients with VT provoked by: | 2474 | 12 401 | 36 | 2.9 (2.0-4.0) | 2.0 (1.1-3.9) | 2.7 (1.3-5.6) | 2.6 (1.2-5.4) |
| OC or HRT use§ | 1258 | 6960 | 9 | 1.3 (0.6-2.5) | 1.3 (0.5-3.6) | 4.0 (1.1-14.9) | 3.9 (1.1-14.4) |
| Pregnancy‖ | 163 | 935 | 0 | NA | NA | NA | NA |
| Surgery‖ | 731 | 3716 | 18 | 4.8 (2.9-7.7) | 3.5 (1.6-7.4) | 2.8 (1.2-6.4) | 2.5 (1.1-6.0) |
| Hospitalization‖ | 798 | 3890 | 13 | 3.3 (1.8-5.7) | 2.3 (1.0-5.4) | 2.2 (0.9-5.4) | 1.9 (0.7-4.8) |
| Malignancy¶ | 422 | 1255 | 8 | 6.4 (2.8-12.6) | 4.3 (1.6-12.1) | 2.1 (0.7-7.0) | 2.0 (0.6-6.7) |
| Partner controls | 2926 | 16 402 | 36 | 2.2 (1.5-3.0) | Reference | Reference | Reference |
| Patients with unprovoked VT | 2006 | 10 022 | 36 | 3.6 (2.5-5.0) | 1.7 (1.1-2.8) | 1.4 (0.9-2.4) | 1.5 (0.9-2.5) |
| Patients with VT provoked by: | 2474 | 12 401 | 36 | 2.9 (2.0-4.0) | 1.4 (0.9-2.2) | 1.8 (1.0-3.0) | 1.7 (1.0-2.9) |
| OC or HRT use§ | 1258 | 6960 | 9 | 1.3 (0.6-2.5) | 0.7 (0.3-1.6) | 1.1 (0.4-3.2) | 1.2 (0.4-3.4) |
| Pregnancy‖ | 163 | 935 | 0 | NA | NA | NA | NA |
| Surgery‖ | 731 | 3716 | 18 | 4.8 (2.9-7.7) | 2.3 (1.3-4.2) | 2.2 (1.2-4.2) | 2.0 (1.0-3.9) |
| Hospitalization‖ | 798 | 3890 | 13 | 3.3 (1.8-5.7) | 1.6 (0.8-3.1) | 1.6 (0.8-3.4) | 1.5 (0.7-3.1) |
| Malignancy¶ | 422 | 1255 | 8 | 6.4 (2.8-12.6) | 3.3 (1.5-7.5) | 2.1 (0.8-5.1) | 2.1 (0.8-5.1) |
HRT, hormone replacement therapy; OC, oral contraception; py, person-years.
Adjusted for anticoagulation therapy.
Adjusted for anticoagulation therapy, age, sex, BMI, and smoking.
Adjusted for anticoagulant therapy, age, sex, BMI, smoking, chronic disease (defined as liver disease, kidney disease, multiple sclerosis, or rheumatoid arthritis), and malignancy, where applicable.
In the year before the index date.
In the 3 months before the index date.
In the 5 years before the index date.