Table 1

MDS patient characteristics and response to miR-21 inhibition

NAge/SexWBC (103/mL)Hgb (g/dL)Plt (103/mL)SubtypeCytogeneticsColonies post treatment with mismatched controlColonies post treatment with miR-21 inhibitor
BFU-ECFU-GMBFU-ECFU-GM
63/M 1.2 14 RCMD +11 204 12 259 24 
79/f 2.9 9.6 29 RAEB −7q 22 26 
68/F 3.5 9.3 35 RAEB −5q, −18 20 37 49 46 
70/M 18.2 8.5 84 RAEB Nml 91 93 121 86 
69/F 5.2 8.8 75 RCMD Nml 62 26 98 25 
NAge/SexWBC (103/mL)Hgb (g/dL)Plt (103/mL)SubtypeCytogeneticsColonies post treatment with mismatched controlColonies post treatment with miR-21 inhibitor
BFU-ECFU-GMBFU-ECFU-GM
63/M 1.2 14 RCMD +11 204 12 259 24 
79/f 2.9 9.6 29 RAEB −7q 22 26 
68/F 3.5 9.3 35 RAEB −5q, −18 20 37 49 46 
70/M 18.2 8.5 84 RAEB Nml 91 93 121 86 
69/F 5.2 8.8 75 RCMD Nml 62 26 98 25 

WBC, white blood cells; plt, platelets; Hgb, hemoglobin.

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