Results of multivariate analysis for nonrelapse mortality, relapse, and overall mortality
| Outcome . | No. of events/no. evaluable . | HR (95% CI) . | P . |
|---|---|---|---|
| Nonrelapse mortality* | |||
| MSD/PS ≥90 | 277/883 | 1.00 | |
| MUD/PS ≥90 | 151/441 | 1.42 (1.15-1.74) | .001 |
| MSD/PS ≤80 | 199/477 | 1.00 | |
| MUD/PS ≤80 | 84/222 | 0.96 (0.74-1.24) | .76 |
| Relapse† | |||
| MSD/PS ≥90 | 252/883 | 1.00 | |
| MUD/PS ≥90 | 167/441 | 1.57 (1.29-1.91) | <.001 |
| MSD/PS ≤80 | 179/477 | 1.00 | |
| MUD/PS ≤80 | 81/222 | 0.86 (0.66-1.12) | .25 |
| Overall mortalityठ| |||
| MSD/PS ≥90 | 479/883 | 1.00 | |
| MUD/PS ≥90 | 293/441 | 1.66 (1.45-1.91) | <.001 |
| MSD/PS ≤80 | 358/477 | 1.00 | |
| MUD/PS ≤80 | 160/222 | 0.90 (0.75-1.09) | .29 |
| Treatment failure|| | |||
| MSD/PS ≥90 | 529/883 | 1.00 | |
| MUD/PS ≥90 | 318/441 | 1.63 (1.43-1.87) | <.001 |
| MSD/PS ≤80 | 378/477 | 1.00 | |
| MUD/PS ≤80 | 165/222 | 0.88 (0.73-1.06) | .18 |
| Outcome . | No. of events/no. evaluable . | HR (95% CI) . | P . |
|---|---|---|---|
| Nonrelapse mortality* | |||
| MSD/PS ≥90 | 277/883 | 1.00 | |
| MUD/PS ≥90 | 151/441 | 1.42 (1.15-1.74) | .001 |
| MSD/PS ≤80 | 199/477 | 1.00 | |
| MUD/PS ≤80 | 84/222 | 0.96 (0.74-1.24) | .76 |
| Relapse† | |||
| MSD/PS ≥90 | 252/883 | 1.00 | |
| MUD/PS ≥90 | 167/441 | 1.57 (1.29-1.91) | <.001 |
| MSD/PS ≤80 | 179/477 | 1.00 | |
| MUD/PS ≤80 | 81/222 | 0.86 (0.66-1.12) | .25 |
| Overall mortalityठ| |||
| MSD/PS ≥90 | 479/883 | 1.00 | |
| MUD/PS ≥90 | 293/441 | 1.66 (1.45-1.91) | <.001 |
| MSD/PS ≤80 | 358/477 | 1.00 | |
| MUD/PS ≤80 | 160/222 | 0.90 (0.75-1.09) | .29 |
| Treatment failure|| | |||
| MSD/PS ≥90 | 529/883 | 1.00 | |
| MUD/PS ≥90 | 318/441 | 1.63 (1.43-1.87) | <.001 |
| MSD/PS ≤80 | 378/477 | 1.00 | |
| MUD/PS ≤80 | 165/222 | 0.88 (0.73-1.06) | .18 |
PS, [patient] performance score.
Model adjusted for disease status, conditioning regimen, donor-recipient sex match, and GVHD prophylaxis.
Model adjusted for disease, disease status, conditioning regimen, and transplantation period.
Model for overall mortality stratified by conditioning regimen.
Model adjusted for patient age, disease, and disease status.
Model adjusted for disease, disease status, and in vivo T-cell depletion.