SIRs for tAML after initial chemotherapy treatment of first primary malignancy in adulthood, 16 SEER registries, 2001-2008
| . | Total patients diagnosed . | Patients who received initial chemotherapy . | tAML among patients who received initial chemotherapy . | |
|---|---|---|---|---|
| First primary malignancy . | N . | N (%) . | N . | SIR* (95% CI) . |
| Total† | 1 333 224 | 380 811 (29) | 408 | 5.72‡ (5.18-6.31) |
| Buccal cavity, pharynx | 32 540 | 12 390 (38) | 5 | 2.24 (0.73-5.23) |
| Esophagus | 7422 | 5147 (69) | 6 | 6.17‡ (2.26-13.42) |
| Stomach | 14 154 | 6868 (49) | 3 | 2.55 (0.53-7.47) |
| Colon | 93 133 | 33 660 (36) | 9 | 1.01 (0.46-1.91) |
| Rectum, rectosigmoid junction | 44 208 | 22 839 (52) | 4 | 0.66 (0.18-1.70) |
| Anus, anal canal, anorectum | 5086 | 3884 (76) | 3 | 3.63 (0.75-10.62) |
| Biliary tract | 14 453 | 5836 (40) | <3 | 2.62 (0.32-9.48) |
| Larynx | 11 324 | 3160 (28) | <3 | 3.14 (0.38-11.35) |
| Lung, bronchus | 92 408 | 46 811 (51) | 35 | 5.11‡ (3.56-7.10) |
| Small-cell | 10 770 | 9505 (88) | 15 | 13.06‡ (7.31-21.54) |
| Non–small-cell | 79 381 | 37 008 (47) | 18 | 3.18‡ (1.88-5.02) |
| Bones and joints | 2301 | 687 (30) | 5 | 98.90‡ (32.11-230.79) |
| Melanoma of the skin | 69 942 | 1137 (2) | <3 | 5.90 (0.15-32.85) |
| Soft tissue (including heart) | 8945 | 2016 (23) | 6 | 23.50‡ (8.62-51.15) |
| Female breast | 255 909 | 116 243 (45) | 151 | 7.86‡ (6.66-9.22) |
| Cervix | 17 012 | 7148 (42) | 4 | 4.98‡ (1.36-12.75) |
| Endometrium | 46 740 | 5258 (11) | 5 | 6.19‡ (2.01-14.45) |
| Ovary | 20 707 | 14 970 (72) | 11 | 4.43‡ (2.21-7.92) |
| Prostate | 300 016 | 1959 (1) | 6 | 7.92‡ (2.91-17.25) |
| Testis | 12 417 | 3252 (26) | 4 | 18.69‡ (5.09-47.85) |
| Urinary bladder | 56 823 | 6048 (11) | <3 | 1.10 (0.13-3.97) |
| Brain, central nervous system | 12 870 | 6283 (49) | 3 | 7.38‡ (1.52-21.56) |
| Hodgkin lymphoma | 10 314 | 8710 (84) | 22 | 22.59‡ (14.15-34.20) |
| Non-Hodgkin lymphoma | 57 476 | 35 282 (61) | 81 | 8.56‡ (6.80-10.64) |
| DLBCL | 18 567 | 15 790 (85) | 31 | 7.34‡ (4.99-10.42) |
| Follicular lymphoma | 13 692 | 7780 (57) | 17 | 8.18‡ (4.77-13.10) |
| Myeloma | 15 732 | 9753 (62) | 15 | 6.58‡ (3.68-10.86) |
| . | Total patients diagnosed . | Patients who received initial chemotherapy . | tAML among patients who received initial chemotherapy . | |
|---|---|---|---|---|
| First primary malignancy . | N . | N (%) . | N . | SIR* (95% CI) . |
| Total† | 1 333 224 | 380 811 (29) | 408 | 5.72‡ (5.18-6.31) |
| Buccal cavity, pharynx | 32 540 | 12 390 (38) | 5 | 2.24 (0.73-5.23) |
| Esophagus | 7422 | 5147 (69) | 6 | 6.17‡ (2.26-13.42) |
| Stomach | 14 154 | 6868 (49) | 3 | 2.55 (0.53-7.47) |
| Colon | 93 133 | 33 660 (36) | 9 | 1.01 (0.46-1.91) |
| Rectum, rectosigmoid junction | 44 208 | 22 839 (52) | 4 | 0.66 (0.18-1.70) |
| Anus, anal canal, anorectum | 5086 | 3884 (76) | 3 | 3.63 (0.75-10.62) |
| Biliary tract | 14 453 | 5836 (40) | <3 | 2.62 (0.32-9.48) |
| Larynx | 11 324 | 3160 (28) | <3 | 3.14 (0.38-11.35) |
| Lung, bronchus | 92 408 | 46 811 (51) | 35 | 5.11‡ (3.56-7.10) |
| Small-cell | 10 770 | 9505 (88) | 15 | 13.06‡ (7.31-21.54) |
| Non–small-cell | 79 381 | 37 008 (47) | 18 | 3.18‡ (1.88-5.02) |
| Bones and joints | 2301 | 687 (30) | 5 | 98.90‡ (32.11-230.79) |
| Melanoma of the skin | 69 942 | 1137 (2) | <3 | 5.90 (0.15-32.85) |
| Soft tissue (including heart) | 8945 | 2016 (23) | 6 | 23.50‡ (8.62-51.15) |
| Female breast | 255 909 | 116 243 (45) | 151 | 7.86‡ (6.66-9.22) |
| Cervix | 17 012 | 7148 (42) | 4 | 4.98‡ (1.36-12.75) |
| Endometrium | 46 740 | 5258 (11) | 5 | 6.19‡ (2.01-14.45) |
| Ovary | 20 707 | 14 970 (72) | 11 | 4.43‡ (2.21-7.92) |
| Prostate | 300 016 | 1959 (1) | 6 | 7.92‡ (2.91-17.25) |
| Testis | 12 417 | 3252 (26) | 4 | 18.69‡ (5.09-47.85) |
| Urinary bladder | 56 823 | 6048 (11) | <3 | 1.10 (0.13-3.97) |
| Brain, central nervous system | 12 870 | 6283 (49) | 3 | 7.38‡ (1.52-21.56) |
| Hodgkin lymphoma | 10 314 | 8710 (84) | 22 | 22.59‡ (14.15-34.20) |
| Non-Hodgkin lymphoma | 57 476 | 35 282 (61) | 81 | 8.56‡ (6.80-10.64) |
| DLBCL | 18 567 | 15 790 (85) | 31 | 7.34‡ (4.99-10.42) |
| Follicular lymphoma | 13 692 | 7780 (57) | 17 | 8.18‡ (4.77-13.10) |
| Myeloma | 15 732 | 9753 (62) | 15 | 6.58‡ (3.68-10.86) |