Bisphosphonate dosing according to renal function
| CrCl rate (mL/min) . | CLO recommended dosage (1600 mg) . | ZOL recommended dosage (mg) . | Recommended infusion time for PAM (90 mg/500 mL NS IV) . |
|---|---|---|---|
| >80 | 100% | ||
| 50-80 | 75% | ||
| 12-50 | 50-75% | ||
| <12 | 50% or discontinue | ||
| >60 | 4.0 | ||
| 50-60 | 3.5 | ||
| 40-49 | 3.3 | ||
| 30-39 | 3.0 | ||
| <30 | Not recommended | Not recommended | |
| >30 | 2-4 h |
| CrCl rate (mL/min) . | CLO recommended dosage (1600 mg) . | ZOL recommended dosage (mg) . | Recommended infusion time for PAM (90 mg/500 mL NS IV) . |
|---|---|---|---|
| >80 | 100% | ||
| 50-80 | 75% | ||
| 12-50 | 50-75% | ||
| <12 | 50% or discontinue | ||
| >60 | 4.0 | ||
| 50-60 | 3.5 | ||
| 40-49 | 3.3 | ||
| 30-39 | 3.0 | ||
| <30 | Not recommended | Not recommended | |
| >30 | 2-4 h |
CLO, clodronate; IV, intravenous; NS, ; PAM, pamidronate; ZOL, zoledronic acid; NS, normal saline.