Table 1 GRADE recommendations for... | American Society of Hematology

Table 1

GRADE recommendations for grading levels of evidence

Grade
1	Evidence strongly suggests that the benefit of the procedure outweighs potential risk or risks of the procedure outweighs potential benefits	A	Consistent evidence from systemic reviews or high-quality randomized studies or high-quality observational studies
2	Evidence suggests the benefit and risk of a procedure is finely balanced or uncertain	B	Evidence from randomized and observational studies with important methodological flaws
		C	Evidence from randomized and observational studies with major methodological flaws or other sources of evidence (eg, case series)

Grade
1	Evidence strongly suggests that the benefit of the procedure outweighs potential risk or risks of the procedure outweighs potential benefits	A	Consistent evidence from systemic reviews or high-quality randomized studies or high-quality observational studies
2	Evidence suggests the benefit and risk of a procedure is finely balanced or uncertain	B	Evidence from randomized and observational studies with important methodological flaws
		C	Evidence from randomized and observational studies with major methodological flaws or other sources of evidence (eg, case series)