Table 3 Difference in MFI value and... | American Society of Hematology

Table 3

Difference in MFI value and percentage of HLA-Ia reactivity of therapeutic IVIg preparations between regular beads and iBeads (reduced amount of heavy chain) coated with HLA-A (A), HLA-B (B), and HLA-Cw (C)

Antigen	Sandaglobulin			Gamunex-C						GamaSTAN			Octagam
	Sandaglobulin			Lot NKLG1			Lot NKLK1			GamaSTAN			Octagam
	Regular, lot 7	iBead, lot 6	Difference	Regular, lot 7	iBead, lot 6	Difference	Regular, lot 7	iBead, lot 6	Difference	Regular, lot 7	iBead, lot 6	Difference	Regular, lot 7	iBead, lot 6	Difference
	(1:4)	(1:4)	%	(1:8)	(1:8)	%	(1:8)	(1:8)	%	(1:8)	(1:8)	%	(1:8)	(1:8)	%
A.
Album in–NC	1196	667	–44	10753	7147	–34	10268	7799	–24	3793	5034	33	2340	1673	–29
A*0101(A1)	0	551	100	368	3589	875	0	1355	100	0	809	100	260	262	1
A*0201(A2)	8	772	9550	0	4976	100	0	1989	100	659	2215	236	0	1002	100
A*0203(A2)	0	354	100	0	2975	100	233	648	178	24	328	1258	0	0	0
A*0206(A2)	125	799	539	445	4409	891	913	2303	152	471	3061	550	780	1330	71
A*0301(A3)	2	199	9850	0	2839	100	410	–211	–151	236	0	–100	515	0	–100
A*1101(A11)	187	439	135	2535	3763	48	1942	1301	–33	1073	1226	14	1556	351	–77
A*1102(A11)	115	475	313	824	2861	247	529	858	62	1089	1859	71	829	46	–94
A*2301(A23)	373	667	79	1775	3567	101	1125	1338	19	1877	1178	–37	1417	576	–59
A*2402(A24)	567	725	28	3171	4513	42	2352	2090	–11	2312	2218	–4	3071	663	–78
A*2403(A24)	366	593	62	2701	3977	47	2049	1668	–19	2297	1462	–36	2868	443	–85
A*2501(A25)	143	581	306	506	2975	488	488	408	–16	1436	1905	33	790	58	–93
A*2601(A26)	188	638	239	1732	4418	155	1116	1560	40	1004	1565	56	1169	402	–66
A*2901(A29)	275	916	233	1243	4562	267	634	1418	124	897	3265	264	1046	1172	12
A*2902(A29)	200	932	366	1751	6014	243	820	2892	253	991	4433	348	1578	2268	44
A*3001(A30)	222	540	143	2107	4466	112	1230	1339	9	924	624	–32	928	510	–45
A*3002(A30)	174	526	202	896	3705	314	562	1412	151	1050	929	–11	533	369	–31
A*3101(A31)	0	295	100	166	3411	1955	0	0	0	121	351	189	366	0	–100
A*3201(A32)	255	769	202	875	3764	330	424	915	116	856	1821	113	738	518	–30
A*3301(A33)	185	684	270	1694	4462	163	925	1315	42	1119	1877	68	1494	1358	–9
A*3303 (A33)	0	439	100	476	3329	599	179	517	189	322	725	125	542	152	–72
A*3401(A34)	640	1150	80	3543	5215	47	2149	3415	59	3042	4323	42	2879	2059	–28
A*3402(A34)	0	177	100	0	2053	100	0	0	0	684	1206	76	0	0	0
A*3601(A36)	51	636	1147	916	3949	331	704	1551	120	564	1379	145	778	572	–26
A*4301(A43)	397	949	139	1961	5601	186	1170	2719	132	1913	4182	119	1898	1693	–11
A*6601(A66)	93	783	742	648	5328	722	875	2331	166	1408	2613	86	1695	1019	–40
A*6602(A66)	364	768	111	1101	5194	372	838	1863	122	2362	4316	83	3650	684	–81
A*6801(A68)	0	307	100	0	3148	100	0	662	0	192	634	230	0	0	0
A*6802(A68)	455	596	31	1421	4662	228	1332	1948	46	2060	2084	1	1748	489	–72
A*6901(A69)	470	788	68	2813	6243	122	2777	2885	4	1877	2410	28	1724	814	–53
A*7401(A74)	0	316	100	666	3904	486	224	515	130	80	431	437	201	82	–59
A*8001(A80)	401	564	41	3194	3969	24	1679	1188	–29	2705	2847	5	2289	845	–63
B.
Albumin NC	1196	667	–44	10753	7147	–34	10268	7799	–24	3793	5034	33	2340	1673	–29
B*0702(B7)	309	436	41	1539	2134	39	837	0	–100	2223	2010	–10	714	0	–100
B*0801(B8)	233	274	18	2186	1511	–31	1755	0	–100	884	324	–63	2119	114	–95
B*1301(B13)	524	504	–4	5168	3565	–31	3522	1031	–71	2244	1836	–18	3679	52	–99
B*1302(B13)	476	502	5	3103	1709	–45	2532	0	–100	2222	1199	–46	1943	0	–100
B*1401(B64)	621	206	–67	3133	2100	–33	2276	410	–82	1749	269	–85	2397	102	–96
B*1402(B65)	239	152	–36	2249	929	–59	1441	0	–100	670	0	–100	1458	0	–100
B*1501(B62)	0	148	100	0	749	100	15	53	253	106	394	270	100	0	–100
B*1502(B75)	157	245	56	1525	2008	32	1536	91	–94	526	709	35	861	0	–100
B*1503(B72)	0	0	0	2375	507	–79	2296	0	–100	689	0	–100	1057	0	–100
B*1510(B71)	240	271	13	1434	1452	1	1622	347	–79	857	492	–43	1293	0	–100
B*1511(B75)	637	552	–13	4058	3380	–17	3825	1860	–51	2822	2380	–16	3640	1087	–70
B*1512(B76)	382	1141	199	816	2811	244	942	1418	51	2655	5973	125	1129	1385	23
B*1513(B77)	550	445	–19	4274	2353	–45	3211	841	–74	1238	904	–27	2257	256	–89
B*1516(B63)	799	756	–5	3755	2400	–36	3133	1212	–61	3536	3285	–7	3132	880	–72
B*1801(B18)	0	114	100	538	1142	112	567	0	–100	0	0	0	246	0	–100
B*2705(B27)	141	377	167	388	1657	327	160	0	–100	1366	1085	–21	154	0	–100
B*2708(B27)	13	302	2223	0	1344	100	0	0	0	1067	1407	32	54	0	–100
B*3501(B35)	243	352	45	1672	1614	–3	1478	577	–61	680	653	–4	964	0	–100
B*3701(B37)	1099	740	–33	6133	3639	–41	4788	612	–87	3236	392	–88	9974	0	–100
B*3801(B38)	254	248	–2	1356	1375	1	1259	0	–100	619	0	100	1002	0	–100
B*3901(B39)	0	0	0	0	242	100	0	0	0	0	0		0	0	0
B*4001(B60)	237	409	73	1677	2474	48	1240	93	–93	1723	2286	33	987	4	–100
B*4002(B61)	134	242	81	569	1679	195	0	0	0	1564	1188	–24	271	0	–100
B*4006(B61)	765	359	–53	5394	2144	–60	4341	421	–90	3470	2373	–32	4972	167	–97
B*4101(B41)	32	182	469	716	1486	108	605	0	–100	1067	870	–19	393	0	–100
B*4201(B42)	0	86	100	455	1088	139	13	0	–100	598	286	–52	364	0	–100
B*4402(B44)	683	461	–33	6465	1869	–71	5313	786	–85	4301	3376	–22	3997	702	–82
B*4403(B44)	284	413	45	1110	2395	116	1213	836	–31	3391	2904	–14	1146	698	–39
B*4501(B45)	272	612	125	1106	2110	91	562	399	–29	3667	5397	47	956	308	–68
B*4601(B46)	537	473	–12	3014	3537	17	2450	851	–65	1834	1460	–20	2438	526	–78
B*4701(B47)	355	655	85	2554	2799	10	2031	1235	–39	1771	3211	81	2200	955	–57
B*4801(B48)	297	341	15	3280	3131	–5	1984	757	–62	2252	1694	–25	1863	104	–94
B*4901(B49)	356	630	77	1586	1419	–11	1881	158	–92	1640	446	–73	1340	0	–100
B*5001(B50)	72	198	175	789	968	23	814	0	–100	627	176	–72	505	0	–100
B*5101(B51)	669	687	3	3370	2343	–30	2798	1101	–61	1662	1336	–20	1896	339	–82
B*5102(B51)	688	604	–12	2599	1898	–27	2699	694	–74	1677	476	–72	1671	0	–100
B*5201(B52)	707	869	23	3207	2125	–34	2745	1224	–55	1788	1341	–25	1962	280	–86
B*5301(B53)	692	536	–23	3265	2368	–27	4078	678	–83	2040	478	–77	2561	0	–100
B*5401(B54)	299	168	–44	2623	1463	–44	1455	0	–100	1633	476	–71	2238	0	–100
B*5501(B55)	222	44	–80	3308	1072	–68	1753	0	–100	1558	686	–56	1874	0	–100
B*5601(B56)	507	183	–64	2689	1269	–53	2222	0	–100	1995	0	–100	1607	0	–100
B*5701(B57)	419	560	34	1045	1987	90	942	286	–70	1101	542	–51	957	3	–100
B*5703(B57)	897	382	–57	2710	1620	–40	2983	0	–100	2148	0	–100	2425	0	–100
B*5801(B58)	726	455	–37	4435	1829	–59	3479	662	–81	2758	106	–96	3157	0	–100
B*5901(B59)	502	446	–11	3855	2216	–43	3052	720	–76	1798	1058	–41	2444	470	–81
B*6701(B67)	225	362	61	64	1113	1639	–237	–569	140	1108	603	–46	841	0	–100
B*7301(B73)	243	572	135	1817	3226	78	1945	1022	–47	1755	3145	79	1740	1118	–36
B*7801(B78)	446	556	25	2491	1568	–37	2410	260	–89	1737	283	–84	1786	0	–100
B*8101(B81)	364	550	51	2969	3082	4	1848	1096	–41	2541	2799	10	1323	372	–72
B*8201(B82)	639	360	–44	6055	2731	–55	4783	–193	–104	3857	4259	10	5026	510	–90
C.
Albumin NC	1196	667	–44	10753	7147	–34	10268	7799	−24	3793	5034	33	2340	1673	–29
CW*0102(Cw1)	998	511	–49	5361	5231	–2	4314	1058	−75	4538	2828	–38	7724	1778	–77
CW*0202(Cw2)	1275	719	–44	7890	5379	–32	6814	2800	−59	7183	8101	13	9379	1840	–80
CW*0302(Cw10)	1024	522	–49	4952	4874	–2	4130	1769	−57	4010	2378	–41	5608	1170	–79
CW*0303(Cw9)	703	500	–29	4262	4286	1	3017	1665	−45	2855	2607	–9	3350	1220	–64
CW*0304(Cw10)	844	520	–38	5758	4141	–28	4429	1816	−59	3713	2748	–26	5552	1435	–74
CW*0401(Cw4)	1569	601	–62	7529	3726	–51	6484	1882	−71	6287	5051	–20	9884	2013	–80
CW*0501(Cw5)	1230	710	–42	7553	4013	–47	5975	2020	−66	6968	6352	–9	8769	1513	–83
CW*0602(Cw6)	1557	627	–60	12049	4226	–65	10614	2108	−80	9171	8176	–11	16706	586	–96
CW*0702(Cw7)	1973	746	–62	11789	5474	–54	10541	2402	−77	7620	3483	–54	15321	1619	–89
CW*0801(Cw8)	669	391	–42	5375	3227	–40	4539	467	−90	2833	1937	–32	4419	650	–85
CW*1203(Cw12)	985	636	–35	7102	4807	–32	5608	1946	−65	5804	2663	–54	8662	1624	–81
CW*1402(Cw14)	991	410	–59	7238	3968	–45	6160	1073	−83	4272	1819	–57	8432	976	–88
CW*1502(Cw15)	778	458	–41	4946	3586	–27	3693	1198	−68	6167	7673	24	4819	255	–95
CW*1601(Cw16)	973	613	–37	8463	4069	–52	6851	1557	−77	5376	2954	–45	9259	1111	–88
CW*1701(Cw17)	1487	1050	–29	6561	6148	–6	5638	3253	−42	7856	9610	22	8983	2709	–70
CW*1802(Cw18)	1549	570	–63	8432	3579	–58	7155	1481	−79	7981	7814	–2	10610	873	–92

Antigen	Sandaglobulin			Gamunex-C						GamaSTAN			Octagam
	Sandaglobulin			Lot NKLG1			Lot NKLK1			GamaSTAN			Octagam
	Regular, lot 7	iBead, lot 6	Difference	Regular, lot 7	iBead, lot 6	Difference	Regular, lot 7	iBead, lot 6	Difference	Regular, lot 7	iBead, lot 6	Difference	Regular, lot 7	iBead, lot 6	Difference
	(1:4)	(1:4)	%	(1:8)	(1:8)	%	(1:8)	(1:8)	%	(1:8)	(1:8)	%	(1:8)	(1:8)	%
A.
Album in–NC	1196	667	–44	10753	7147	–34	10268	7799	–24	3793	5034	33	2340	1673	–29
A*0101(A1)	0	551	100	368	3589	875	0	1355	100	0	809	100	260	262	1
A*0201(A2)	8	772	9550	0	4976	100	0	1989	100	659	2215	236	0	1002	100
A*0203(A2)	0	354	100	0	2975	100	233	648	178	24	328	1258	0	0	0
A*0206(A2)	125	799	539	445	4409	891	913	2303	152	471	3061	550	780	1330	71
A*0301(A3)	2	199	9850	0	2839	100	410	–211	–151	236	0	–100	515	0	–100
A*1101(A11)	187	439	135	2535	3763	48	1942	1301	–33	1073	1226	14	1556	351	–77
A*1102(A11)	115	475	313	824	2861	247	529	858	62	1089	1859	71	829	46	–94
A*2301(A23)	373	667	79	1775	3567	101	1125	1338	19	1877	1178	–37	1417	576	–59
A*2402(A24)	567	725	28	3171	4513	42	2352	2090	–11	2312	2218	–4	3071	663	–78
A*2403(A24)	366	593	62	2701	3977	47	2049	1668	–19	2297	1462	–36	2868	443	–85
A*2501(A25)	143	581	306	506	2975	488	488	408	–16	1436	1905	33	790	58	–93
A*2601(A26)	188	638	239	1732	4418	155	1116	1560	40	1004	1565	56	1169	402	–66
A*2901(A29)	275	916	233	1243	4562	267	634	1418	124	897	3265	264	1046	1172	12
A*2902(A29)	200	932	366	1751	6014	243	820	2892	253	991	4433	348	1578	2268	44
A*3001(A30)	222	540	143	2107	4466	112	1230	1339	9	924	624	–32	928	510	–45
A*3002(A30)	174	526	202	896	3705	314	562	1412	151	1050	929	–11	533	369	–31
A*3101(A31)	0	295	100	166	3411	1955	0	0	0	121	351	189	366	0	–100
A*3201(A32)	255	769	202	875	3764	330	424	915	116	856	1821	113	738	518	–30
A*3301(A33)	185	684	270	1694	4462	163	925	1315	42	1119	1877	68	1494	1358	–9
A*3303 (A33)	0	439	100	476	3329	599	179	517	189	322	725	125	542	152	–72
A*3401(A34)	640	1150	80	3543	5215	47	2149	3415	59	3042	4323	42	2879	2059	–28
A*3402(A34)	0	177	100	0	2053	100	0	0	0	684	1206	76	0	0	0
A*3601(A36)	51	636	1147	916	3949	331	704	1551	120	564	1379	145	778	572	–26
A*4301(A43)	397	949	139	1961	5601	186	1170	2719	132	1913	4182	119	1898	1693	–11
A*6601(A66)	93	783	742	648	5328	722	875	2331	166	1408	2613	86	1695	1019	–40
A*6602(A66)	364	768	111	1101	5194	372	838	1863	122	2362	4316	83	3650	684	–81
A*6801(A68)	0	307	100	0	3148	100	0	662	0	192	634	230	0	0	0
A*6802(A68)	455	596	31	1421	4662	228	1332	1948	46	2060	2084	1	1748	489	–72
A*6901(A69)	470	788	68	2813	6243	122	2777	2885	4	1877	2410	28	1724	814	–53
A*7401(A74)	0	316	100	666	3904	486	224	515	130	80	431	437	201	82	–59
A*8001(A80)	401	564	41	3194	3969	24	1679	1188	–29	2705	2847	5	2289	845	–63
B.
Albumin NC	1196	667	–44	10753	7147	–34	10268	7799	–24	3793	5034	33	2340	1673	–29
B*0702(B7)	309	436	41	1539	2134	39	837	0	–100	2223	2010	–10	714	0	–100
B*0801(B8)	233	274	18	2186	1511	–31	1755	0	–100	884	324	–63	2119	114	–95
B*1301(B13)	524	504	–4	5168	3565	–31	3522	1031	–71	2244	1836	–18	3679	52	–99
B*1302(B13)	476	502	5	3103	1709	–45	2532	0	–100	2222	1199	–46	1943	0	–100
B*1401(B64)	621	206	–67	3133	2100	–33	2276	410	–82	1749	269	–85	2397	102	–96
B*1402(B65)	239	152	–36	2249	929	–59	1441	0	–100	670	0	–100	1458	0	–100
B*1501(B62)	0	148	100	0	749	100	15	53	253	106	394	270	100	0	–100
B*1502(B75)	157	245	56	1525	2008	32	1536	91	–94	526	709	35	861	0	–100
B*1503(B72)	0	0	0	2375	507	–79	2296	0	–100	689	0	–100	1057	0	–100
B*1510(B71)	240	271	13	1434	1452	1	1622	347	–79	857	492	–43	1293	0	–100
B*1511(B75)	637	552	–13	4058	3380	–17	3825	1860	–51	2822	2380	–16	3640	1087	–70
B*1512(B76)	382	1141	199	816	2811	244	942	1418	51	2655	5973	125	1129	1385	23
B*1513(B77)	550	445	–19	4274	2353	–45	3211	841	–74	1238	904	–27	2257	256	–89
B*1516(B63)	799	756	–5	3755	2400	–36	3133	1212	–61	3536	3285	–7	3132	880	–72
B*1801(B18)	0	114	100	538	1142	112	567	0	–100	0	0	0	246	0	–100
B*2705(B27)	141	377	167	388	1657	327	160	0	–100	1366	1085	–21	154	0	–100
B*2708(B27)	13	302	2223	0	1344	100	0	0	0	1067	1407	32	54	0	–100
B*3501(B35)	243	352	45	1672	1614	–3	1478	577	–61	680	653	–4	964	0	–100
B*3701(B37)	1099	740	–33	6133	3639	–41	4788	612	–87	3236	392	–88	9974	0	–100
B*3801(B38)	254	248	–2	1356	1375	1	1259	0	–100	619	0	100	1002	0	–100
B*3901(B39)	0	0	0	0	242	100	0	0	0	0	0		0	0	0
B*4001(B60)	237	409	73	1677	2474	48	1240	93	–93	1723	2286	33	987	4	–100
B*4002(B61)	134	242	81	569	1679	195	0	0	0	1564	1188	–24	271	0	–100
B*4006(B61)	765	359	–53	5394	2144	–60	4341	421	–90	3470	2373	–32	4972	167	–97
B*4101(B41)	32	182	469	716	1486	108	605	0	–100	1067	870	–19	393	0	–100
B*4201(B42)	0	86	100	455	1088	139	13	0	–100	598	286	–52	364	0	–100
B*4402(B44)	683	461	–33	6465	1869	–71	5313	786	–85	4301	3376	–22	3997	702	–82
B*4403(B44)	284	413	45	1110	2395	116	1213	836	–31	3391	2904	–14	1146	698	–39
B*4501(B45)	272	612	125	1106	2110	91	562	399	–29	3667	5397	47	956	308	–68
B*4601(B46)	537	473	–12	3014	3537	17	2450	851	–65	1834	1460	–20	2438	526	–78
B*4701(B47)	355	655	85	2554	2799	10	2031	1235	–39	1771	3211	81	2200	955	–57
B*4801(B48)	297	341	15	3280	3131	–5	1984	757	–62	2252	1694	–25	1863	104	–94
B*4901(B49)	356	630	77	1586	1419	–11	1881	158	–92	1640	446	–73	1340	0	–100
B*5001(B50)	72	198	175	789	968	23	814	0	–100	627	176	–72	505	0	–100
B*5101(B51)	669	687	3	3370	2343	–30	2798	1101	–61	1662	1336	–20	1896	339	–82
B*5102(B51)	688	604	–12	2599	1898	–27	2699	694	–74	1677	476	–72	1671	0	–100
B*5201(B52)	707	869	23	3207	2125	–34	2745	1224	–55	1788	1341	–25	1962	280	–86
B*5301(B53)	692	536	–23	3265	2368	–27	4078	678	–83	2040	478	–77	2561	0	–100
B*5401(B54)	299	168	–44	2623	1463	–44	1455	0	–100	1633	476	–71	2238	0	–100
B*5501(B55)	222	44	–80	3308	1072	–68	1753	0	–100	1558	686	–56	1874	0	–100
B*5601(B56)	507	183	–64	2689	1269	–53	2222	0	–100	1995	0	–100	1607	0	–100
B*5701(B57)	419	560	34	1045	1987	90	942	286	–70	1101	542	–51	957	3	–100
B*5703(B57)	897	382	–57	2710	1620	–40	2983	0	–100	2148	0	–100	2425	0	–100
B*5801(B58)	726	455	–37	4435	1829	–59	3479	662	–81	2758	106	–96	3157	0	–100
B*5901(B59)	502	446	–11	3855	2216	–43	3052	720	–76	1798	1058	–41	2444	470	–81
B*6701(B67)	225	362	61	64	1113	1639	–237	–569	140	1108	603	–46	841	0	–100
B*7301(B73)	243	572	135	1817	3226	78	1945	1022	–47	1755	3145	79	1740	1118	–36
B*7801(B78)	446	556	25	2491	1568	–37	2410	260	–89	1737	283	–84	1786	0	–100
B*8101(B81)	364	550	51	2969	3082	4	1848	1096	–41	2541	2799	10	1323	372	–72
B*8201(B82)	639	360	–44	6055	2731	–55	4783	–193	–104	3857	4259	10	5026	510	–90
C.
Albumin NC	1196	667	–44	10753	7147	–34	10268	7799	−24	3793	5034	33	2340	1673	–29
CW*0102(Cw1)	998	511	–49	5361	5231	–2	4314	1058	−75	4538	2828	–38	7724	1778	–77
CW*0202(Cw2)	1275	719	–44	7890	5379	–32	6814	2800	−59	7183	8101	13	9379	1840	–80
CW*0302(Cw10)	1024	522	–49	4952	4874	–2	4130	1769	−57	4010	2378	–41	5608	1170	–79
CW*0303(Cw9)	703	500	–29	4262	4286	1	3017	1665	−45	2855	2607	–9	3350	1220	–64
CW*0304(Cw10)	844	520	–38	5758	4141	–28	4429	1816	−59	3713	2748	–26	5552	1435	–74
CW*0401(Cw4)	1569	601	–62	7529	3726	–51	6484	1882	−71	6287	5051	–20	9884	2013	–80
CW*0501(Cw5)	1230	710	–42	7553	4013	–47	5975	2020	−66	6968	6352	–9	8769	1513	–83
CW*0602(Cw6)	1557	627	–60	12049	4226	–65	10614	2108	−80	9171	8176	–11	16706	586	–96
CW*0702(Cw7)	1973	746	–62	11789	5474	–54	10541	2402	−77	7620	3483	–54	15321	1619	–89
CW*0801(Cw8)	669	391	–42	5375	3227	–40	4539	467	−90	2833	1937	–32	4419	650	–85
CW*1203(Cw12)	985	636	–35	7102	4807	–32	5608	1946	−65	5804	2663	–54	8662	1624	–81
CW*1402(Cw14)	991	410	–59	7238	3968	–45	6160	1073	−83	4272	1819	–57	8432	976	–88
CW*1502(Cw15)	778	458	–41	4946	3586	–27	3693	1198	−68	6167	7673	24	4819	255	–95
CW*1601(Cw16)	973	613	–37	8463	4069	–52	6851	1557	−77	5376	2954	–45	9259	1111	–88
CW*1701(Cw17)	1487	1050	–29	6561	6148	–6	5638	3253	−42	7856	9610	22	8983	2709	–70
CW*1802(Cw18)	1549	570	–63	8432	3579	–58	7155	1481	−79	7981	7814	–2	10610	873	–92

An HLA allele with iBead that is higher than that of the regular bead (bold) indicates that the HLA reactivity in question is toward intact HLA. Percentage of increase refers to the same. An MFI of an allele with iBead that is lower than that of the regular bead indicates that the affinity of the antibody is toward the heavy chain of HLA. Percentage of decrease refers to the same.

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