Number of HLA-A, HLA-B, and HLA-Cw alleles together with HLA-Ib alleles recognized by IVIg from different sources
| IVIg source . | Reactivity to different HLA-class Ia and Ib antigens . | |||||
|---|---|---|---|---|---|---|
| Number of HLA-Ia alleles reactive to IVIg . | IVIg reactive HLA-Ib antigens . | |||||
| A . | B . | Cw . | E . | F . | G . | |
| GamaSTAN | 31 | 50 | 16 | + | + | + |
| Octagam | 30 | 47 | 16 | + | + | + |
| Sandoglobulin | 30 | 47 | 16 | + | + | + |
| GlobEX | 20 | 39 | 16 | + | + | + |
| IVIg source . | Reactivity to different HLA-class Ia and Ib antigens . | |||||
|---|---|---|---|---|---|---|
| Number of HLA-Ia alleles reactive to IVIg . | IVIg reactive HLA-Ib antigens . | |||||
| A . | B . | Cw . | E . | F . | G . | |
| GamaSTAN | 31 | 50 | 16 | + | + | + |
| Octagam | 30 | 47 | 16 | + | + | + |
| Sandoglobulin | 30 | 47 | 16 | + | + | + |
| GlobEX | 20 | 39 | 16 | + | + | + |
The most noteworthy finding is that all IVIg preparations recognize most of the HLA class-Ia alleles and all HLA-Ib molecules, namely, HLA-E, HLA-F, and HLA-G. All preparations reacted with all 16 beads coated with HLA-Cw alleles. Such uniform recognition is not seen with other HLA-Ia alleles. All preparations of IVIg contained antibody reacting to HLA-E, HLA-F, and HLA-G.