Frequency of kinase alterations
| Subgroup . | NCI high risk (n = 884), n (%) . | NCI standard risk, (n = 505), n (%) . | Total (n = 1389), n (%) . | P, high vs standard risk* . |
|---|---|---|---|---|
| Ph-like ALL | 198 (22.4) | 86 (17.0) | 284 (20.4) | .019 |
| CRLF2 rearrangement | 96 (10.9) | 29 (5.7) | 125 (9.0) | .0012 |
| IGH-CRLF2 | 56 (6.3) | 5 (1.0) | 61 (4.4) | <.001 |
| P2RY8-CRLF2 | 40 (4.5) | 24 (4.8) | 64 (4.6) | .89 |
| CRLF2 rearrangement with JAK-STAT mutation | 46 (5.2) | 17 (3.4) | 63 (4.5) | .14 |
| CRLF2 rearrangement without JAK-STAT mutation | 50 (5.7) | 12 (2.4) | 62 (4.5) | .0043 |
| Non-CRLF2 | 102 (11.5) | 57 (11.3) | 159 (11.4) | .93 |
| ABL1-class fusions† | 35 (4.0) | 5 (1.0) | 40 (2.9) | .0012 |
| JAK2 rearrangement | 9 (1.0) | 5 (1.0) | 14 (1.0) | .99 |
| EPOR rearrangement | 11 (1.2) | 0 (0) | 11 (0.8) | .0095 |
| Other kinase‡ | 7 (0.8) | 6 (1.2) | 13 (0.9) | .56 |
| Other JAK-STAT§ | 12 (1.4) | 6 (1.2) | 18 (1.3) | .99 |
| Ras | 6 (0.7) | 11 (2.2) | 17 (1.2) | .021 |
| No kinase identified | 18 (2.0) | 24 (4.8) | 42 (3.0) | .0055 |
| Subgroup . | NCI high risk (n = 884), n (%) . | NCI standard risk, (n = 505), n (%) . | Total (n = 1389), n (%) . | P, high vs standard risk* . |
|---|---|---|---|---|
| Ph-like ALL | 198 (22.4) | 86 (17.0) | 284 (20.4) | .019 |
| CRLF2 rearrangement | 96 (10.9) | 29 (5.7) | 125 (9.0) | .0012 |
| IGH-CRLF2 | 56 (6.3) | 5 (1.0) | 61 (4.4) | <.001 |
| P2RY8-CRLF2 | 40 (4.5) | 24 (4.8) | 64 (4.6) | .89 |
| CRLF2 rearrangement with JAK-STAT mutation | 46 (5.2) | 17 (3.4) | 63 (4.5) | .14 |
| CRLF2 rearrangement without JAK-STAT mutation | 50 (5.7) | 12 (2.4) | 62 (4.5) | .0043 |
| Non-CRLF2 | 102 (11.5) | 57 (11.3) | 159 (11.4) | .93 |
| ABL1-class fusions† | 35 (4.0) | 5 (1.0) | 40 (2.9) | .0012 |
| JAK2 rearrangement | 9 (1.0) | 5 (1.0) | 14 (1.0) | .99 |
| EPOR rearrangement | 11 (1.2) | 0 (0) | 11 (0.8) | .0095 |
| Other kinase‡ | 7 (0.8) | 6 (1.2) | 13 (0.9) | .56 |
| Other JAK-STAT§ | 12 (1.4) | 6 (1.2) | 18 (1.3) | .99 |
| Ras | 6 (0.7) | 11 (2.2) | 17 (1.2) | .021 |
| No kinase identified | 18 (2.0) | 24 (4.8) | 42 (3.0) | .0055 |