The 31 SNP associations with venous thrombosis in MEGA and in the literature13-17,19-26
| Gene . | SNP . | Chromosome . | Position . | MEGA . | Literature average OR . | |||
|---|---|---|---|---|---|---|---|---|
| Risk allele frequency, % . | OR . | 95% CI . | ||||||
| Cases . | Controls . | |||||||
| F5 | rs6025 | 1 | 167.785.673 | 10 | 3 | 4.30 | 3.70-4.99 | 3.79 |
| F2 | rs1799963 | 11 | 46.717.631 | 6 | 2 | 3.01 | 2.36-3.85 | 2.78 |
| ABO | rs8176719 | 9 | 136.132.908 | 47 | 34 | 1.74 | 1.63-1.87 | 1.85 |
| FGG | rs2066865 | 4 | 155.744.726 | 34 | 27 | 1.41 | 1.32-1.51 | 1.56 |
| F11 | rs2036914 | 4 | 187.429.475 | 59 | 52 | 1.35 | 1.26-1.44 | 1.32 |
| PROCR | rs2069951 | 20 | 33.227.425 | 7 | 5 | 1.32 | 1.16-1.51 | 1.30 |
| F11 | rs2289252 | 4 | 187.444.375 | 48 | 41 | 1.36 | 1.28-1.45 | 1.26 |
| F9 | rs4149755 | X | 138.451.778 | 7 | 6 | 1.11 | 0.99-1.24 | 1.24 |
| PROCR | rs2069952 | 20 | 33.227.612 | 64 | 60 | 1.21 | 1.13-1.29 | 1.21 |
| SERPINC1 | rs2227589 | 1 | 172.152.839 | 11 | 9 | 1.27 | 1.15-1.41 | 1.20 |
| HIVEP1 | rs169713 | 6 | 11.920.517 | 22 | 20 | 1.10 | 1.01-1.19 | 1.20 |
| F2 | rs3136516 | 11 | 46.717.332 | 52 | 49 | 1.12 | 1.06-1.20 | 1.19 |
| F5 | rs1800595 | 1 | 167.776.972 | 6 | 5 | 1.18 | 1.03-1.36 | 1.18 |
| PROC | rs1799809 | 2 | 127.892.345 | 47 | 43 | 1.17 | 1.10-1.25 | 1.17 |
| PROCR | rs867186 | 20 | 33.228.215 | 14 | 12 | 1.18 | 1.07-1.29 | 1.17 |
| VWF | rs1063856 | 12 | 6.153.534 | 37 | 33 | 1.18 | 1.10-1.26 | 1.16 |
| GP6 | rs1613662 | 19 | 60.228.407 | 84 | 82 | 1.18 | 1.09-1.29 | 1.15 |
| F2 | rs3136520 | 11 | 46.699.808 | 3 | 2 | 1.09 | 0.89-1.32 | 1.13 |
| F8 | rs1800291 | X | 153.811.479 | 85 | 83 | 1.12 | 1.05-1.20 | 1.13 |
| STXBP5 | rs1039084 | 6 | 147.635.413 | 42 | 45 | 0.90 | 0.84-0.96 | 0.90 |
| NAT8B | rs2001490 | 2 | 73.781.606 | 40 | 37 | 1.13 | 1.06-1.20 | 1.10 |
| F13B | rs6003 | 1 | 195.297.644 | 9 | 10 | 1.11 | 1.00-1.24 | 1.09 |
| RGS7 | rs670659 | 1 | 239.228.398 | 67 | 64 | 1.14 | 1.06-1.22 | 1.09 |
| F9 | rs6048 | X | 138.460.946 | 72 | 70 | 1.09 | 1.03-1.16 | 1.08 |
| F5 | rs4524 | 1 | 167.778.379 | 79 | 74 | 1.31 | 1.22-1.42 | 0.92 |
| F13A1 | rs5985 | 6 | 6.263.794 | 76 | 76 | 1.03 | 0.95-1.10 | 0.93 |
| F3 | 1208 indel | 1 | 94.780.000 | 46 | 46 | 1.02 | 0.96-1.09 | 1.06 |
| TFPI | rs8176592 | 2 | 188.040.937 | 69 | 68 | 1.04 | 0.97-1.11 | 1.06 |
| F11 | rs3822057 | 4 | 187.425.146 | 55 | 49 | 1.31 | 1.23-1.39 | 1.06 |
| NR1I2 | rs1523127 | 3 | 120.983.729 | 41 | 38 | 1.15 | 1.08-1.23 | 1.05 |
| CPB2 | rs3742264 | 13 | 45.546.095 | 69 | 68 | 1.04 | 0.97-1.11 | 1.01 |
| Gene . | SNP . | Chromosome . | Position . | MEGA . | Literature average OR . | |||
|---|---|---|---|---|---|---|---|---|
| Risk allele frequency, % . | OR . | 95% CI . | ||||||
| Cases . | Controls . | |||||||
| F5 | rs6025 | 1 | 167.785.673 | 10 | 3 | 4.30 | 3.70-4.99 | 3.79 |
| F2 | rs1799963 | 11 | 46.717.631 | 6 | 2 | 3.01 | 2.36-3.85 | 2.78 |
| ABO | rs8176719 | 9 | 136.132.908 | 47 | 34 | 1.74 | 1.63-1.87 | 1.85 |
| FGG | rs2066865 | 4 | 155.744.726 | 34 | 27 | 1.41 | 1.32-1.51 | 1.56 |
| F11 | rs2036914 | 4 | 187.429.475 | 59 | 52 | 1.35 | 1.26-1.44 | 1.32 |
| PROCR | rs2069951 | 20 | 33.227.425 | 7 | 5 | 1.32 | 1.16-1.51 | 1.30 |
| F11 | rs2289252 | 4 | 187.444.375 | 48 | 41 | 1.36 | 1.28-1.45 | 1.26 |
| F9 | rs4149755 | X | 138.451.778 | 7 | 6 | 1.11 | 0.99-1.24 | 1.24 |
| PROCR | rs2069952 | 20 | 33.227.612 | 64 | 60 | 1.21 | 1.13-1.29 | 1.21 |
| SERPINC1 | rs2227589 | 1 | 172.152.839 | 11 | 9 | 1.27 | 1.15-1.41 | 1.20 |
| HIVEP1 | rs169713 | 6 | 11.920.517 | 22 | 20 | 1.10 | 1.01-1.19 | 1.20 |
| F2 | rs3136516 | 11 | 46.717.332 | 52 | 49 | 1.12 | 1.06-1.20 | 1.19 |
| F5 | rs1800595 | 1 | 167.776.972 | 6 | 5 | 1.18 | 1.03-1.36 | 1.18 |
| PROC | rs1799809 | 2 | 127.892.345 | 47 | 43 | 1.17 | 1.10-1.25 | 1.17 |
| PROCR | rs867186 | 20 | 33.228.215 | 14 | 12 | 1.18 | 1.07-1.29 | 1.17 |
| VWF | rs1063856 | 12 | 6.153.534 | 37 | 33 | 1.18 | 1.10-1.26 | 1.16 |
| GP6 | rs1613662 | 19 | 60.228.407 | 84 | 82 | 1.18 | 1.09-1.29 | 1.15 |
| F2 | rs3136520 | 11 | 46.699.808 | 3 | 2 | 1.09 | 0.89-1.32 | 1.13 |
| F8 | rs1800291 | X | 153.811.479 | 85 | 83 | 1.12 | 1.05-1.20 | 1.13 |
| STXBP5 | rs1039084 | 6 | 147.635.413 | 42 | 45 | 0.90 | 0.84-0.96 | 0.90 |
| NAT8B | rs2001490 | 2 | 73.781.606 | 40 | 37 | 1.13 | 1.06-1.20 | 1.10 |
| F13B | rs6003 | 1 | 195.297.644 | 9 | 10 | 1.11 | 1.00-1.24 | 1.09 |
| RGS7 | rs670659 | 1 | 239.228.398 | 67 | 64 | 1.14 | 1.06-1.22 | 1.09 |
| F9 | rs6048 | X | 138.460.946 | 72 | 70 | 1.09 | 1.03-1.16 | 1.08 |
| F5 | rs4524 | 1 | 167.778.379 | 79 | 74 | 1.31 | 1.22-1.42 | 0.92 |
| F13A1 | rs5985 | 6 | 6.263.794 | 76 | 76 | 1.03 | 0.95-1.10 | 0.93 |
| F3 | 1208 indel | 1 | 94.780.000 | 46 | 46 | 1.02 | 0.96-1.09 | 1.06 |
| TFPI | rs8176592 | 2 | 188.040.937 | 69 | 68 | 1.04 | 0.97-1.11 | 1.06 |
| F11 | rs3822057 | 4 | 187.425.146 | 55 | 49 | 1.31 | 1.23-1.39 | 1.06 |
| NR1I2 | rs1523127 | 3 | 120.983.729 | 41 | 38 | 1.15 | 1.08-1.23 | 1.05 |
| CPB2 | rs3742264 | 13 | 45.546.095 | 69 | 68 | 1.04 | 0.97-1.11 | 1.01 |