Differentially regulated signaling proteins detected by the phosphotyrosine immunoprecipitation-based proteomic approach comparing basal and rhodocytin-stimulated platelets
| Function . | Uniprot code . | Protein . |
|---|---|---|
| Adapter | 1433E_HUMAN | 14-3-3 protein ϵ |
| 1433F_HUMAN | 14-3-3 protein η | |
| 1433G_HUMAN | 14-3-3 protein γ | |
| 1433Z_HUMAN | 14-3-3 protein ζ/δ | |
| DOK2_HUMAN | Docking protein 2 (Dok-2) | |
| FYB_HUMAN | FYN-binding protein (ADAP, SLAP-130) | |
| GRAP2_HUMAN | GRB2-related adapter protein 2 (Gads) | |
| GRB2_HUMAN | Growth factor receptor-bound protein 2 (Grb2) | |
| LCP2_HUMAN | Lymphocyte cytosolic protein 2 (SLP-76) | |
| SKAP2_HUMAN | Src kinase-associated phosphoprotein 2 (SKAP-HOM) | |
| Kinase | BTK_HUMAN | Tyrosine-protein kinase BTK |
| FER_HUMAN | Tyrosine-protein kinase Fer | |
| FES_HUMAN | Proto-oncogene tyrosine-protein kinase Fes/Fps | |
| FYN_HUMAN | Tyrosine-protein kinase Fyn | |
| KSYK_HUMAN | Tyrosine-protein kinase SYK | |
| LYN_HUMAN | Tyrosine-protein kinase Lyn | |
| MK14_HUMAN | Mitogen-activated protein kinase 14 | |
| SRC_HUMAN | Proto-oncogene tyrosine-protein kinase Src | |
| Phosphatase | MYPT1_HUMAN | Protein phosphatase 1 regulatory subunit 12A |
| PGAM5_HUMAN | Serine/threonine-protein phosphatase PGAM5, mitochondrial | |
| PTN6_HUMAN | Tyrosine-protein phosphatase non-receptor type 6 (SHP-1) | |
| PTPRJ_HUMAN | Receptor-type tyrosine-protein phosphatase eta (CD148) | |
| SHIP1_HUMAN | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (SHIP-1) | |
| Receptor | CLC1B_HUMAN | C-type lectin domain family 1 member B (CLEC-2) |
| GP1BA_HUMAN | Platelet glycoprotein Ib α chain | |
| ITA2B_HUMAN | Integrin α-IIb | |
| PECA1_HUMAN | Platelet endothelial cell adhesion molecule (PECAM-1) | |
| Other | ANXA1_HUMAN | Annexin A1 |
| ANXA2_HUMAN | Annexin A2 | |
| DEN2C_HUMAN | DENN domain-containing protein 2C | |
| PLCG2_HUMAN | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase γ-2 (PLCγ2) | |
| PPIP2_HUMAN | Proline-serine-threonine phosphatase-interacting protein 2 | |
| VAV_HUMAN | Proto-oncogene vav | |
| VAV3_HUMAN | Guanine nucleotide exchange factor VAV3 |
| Function . | Uniprot code . | Protein . |
|---|---|---|
| Adapter | 1433E_HUMAN | 14-3-3 protein ϵ |
| 1433F_HUMAN | 14-3-3 protein η | |
| 1433G_HUMAN | 14-3-3 protein γ | |
| 1433Z_HUMAN | 14-3-3 protein ζ/δ | |
| DOK2_HUMAN | Docking protein 2 (Dok-2) | |
| FYB_HUMAN | FYN-binding protein (ADAP, SLAP-130) | |
| GRAP2_HUMAN | GRB2-related adapter protein 2 (Gads) | |
| GRB2_HUMAN | Growth factor receptor-bound protein 2 (Grb2) | |
| LCP2_HUMAN | Lymphocyte cytosolic protein 2 (SLP-76) | |
| SKAP2_HUMAN | Src kinase-associated phosphoprotein 2 (SKAP-HOM) | |
| Kinase | BTK_HUMAN | Tyrosine-protein kinase BTK |
| FER_HUMAN | Tyrosine-protein kinase Fer | |
| FES_HUMAN | Proto-oncogene tyrosine-protein kinase Fes/Fps | |
| FYN_HUMAN | Tyrosine-protein kinase Fyn | |
| KSYK_HUMAN | Tyrosine-protein kinase SYK | |
| LYN_HUMAN | Tyrosine-protein kinase Lyn | |
| MK14_HUMAN | Mitogen-activated protein kinase 14 | |
| SRC_HUMAN | Proto-oncogene tyrosine-protein kinase Src | |
| Phosphatase | MYPT1_HUMAN | Protein phosphatase 1 regulatory subunit 12A |
| PGAM5_HUMAN | Serine/threonine-protein phosphatase PGAM5, mitochondrial | |
| PTN6_HUMAN | Tyrosine-protein phosphatase non-receptor type 6 (SHP-1) | |
| PTPRJ_HUMAN | Receptor-type tyrosine-protein phosphatase eta (CD148) | |
| SHIP1_HUMAN | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (SHIP-1) | |
| Receptor | CLC1B_HUMAN | C-type lectin domain family 1 member B (CLEC-2) |
| GP1BA_HUMAN | Platelet glycoprotein Ib α chain | |
| ITA2B_HUMAN | Integrin α-IIb | |
| PECA1_HUMAN | Platelet endothelial cell adhesion molecule (PECAM-1) | |
| Other | ANXA1_HUMAN | Annexin A1 |
| ANXA2_HUMAN | Annexin A2 | |
| DEN2C_HUMAN | DENN domain-containing protein 2C | |
| PLCG2_HUMAN | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase γ-2 (PLCγ2) | |
| PPIP2_HUMAN | Proline-serine-threonine phosphatase-interacting protein 2 | |
| VAV_HUMAN | Proto-oncogene vav | |
| VAV3_HUMAN | Guanine nucleotide exchange factor VAV3 |