Table 1

Summary of SNPs with suggestive genome-wide significance (P < 10−5)

SNPChromosomePosition build 36MI/MA alleleMIFTDT (all)
TDT (nonvascular subset)
Next gene (distance in bp)
T/U ratioP valueP value perm*ORT/U ratioP valueOR
rs1364044 5 33915549 A/G 0.296 147/77 2.91 × 10−6 5.00 × 10−5 1.91 105/57 1.62 × 10−4 1.84 ADAMTS12 (0) 
rs2084898 11 119531958 A/G 0.126 90/38 4.30 × 10−6 5.00 × 10−5 2.37 76/25 3.88 × 10−7 3.04 TRIM29 (−44′765) 
rs469568 5 178596014 T/G 0.483 166/94 8.00 × 10−6 5.00 × 10−5 1.77 120/64 3.65 × 10−5 1.87 ADAMTS2 (0) 
rs4663691 2 237565291 G/A 0.238 133/70 9.79 × 10−6 5.00 × 10−5 1.9 101/53 1.10 × 10−4 1.91 COPS8 (93′403) 
SNPChromosomePosition build 36MI/MA alleleMIFTDT (all)
TDT (nonvascular subset)
Next gene (distance in bp)
T/U ratioP valueP value perm*ORT/U ratioP valueOR
rs1364044 5 33915549 A/G 0.296 147/77 2.91 × 10−6 5.00 × 10−5 1.91 105/57 1.62 × 10−4 1.84 ADAMTS12 (0) 
rs2084898 11 119531958 A/G 0.126 90/38 4.30 × 10−6 5.00 × 10−5 2.37 76/25 3.88 × 10−7 3.04 TRIM29 (−44′765) 
rs469568 5 178596014 T/G 0.483 166/94 8.00 × 10−6 5.00 × 10−5 1.77 120/64 3.65 × 10−5 1.87 ADAMTS2 (0) 
rs4663691 2 237565291 G/A 0.238 133/70 9.79 × 10−6 5.00 × 10−5 1.9 101/53 1.10 × 10−4 1.91 COPS8 (93′403) 

MI indicates minor allele; MA, major allele; MIF, minor allele frequency; T/U ratio, transmitted/untransmitted minor allele ratio; and OR, odds ratio.

*

P value after 20 000 gene-dropping permutations.

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