Characteristics of acute chest syndrome events
| . | Hydroxyurea, N = 96 . | Placebo, N = 97 . | P . |
|---|---|---|---|
| No. (%) | 8 (8.3) | 27 (27.8) | |
| Median age at event, mo (range) | 26 (15-30) | 27 (12-39) | .67 |
| Median visit week (range) | 46 (2-80) | 55 (0-99) | .22 |
| Associated symptoms | |||
| Fever | 7 (87.5) | 25 (92.6) | .55 |
| Dactylitis | 0 | 1 (3.7) | 1.00 |
| Pain | 4 (50) | 7 (25.9) | .23 |
| Absolute neutrophil count, < 0.5 × 109/L | 0 | 9 (33.3) | .08 |
| Sepsis | 0 | 1 (3.7) | 1.00 |
| Pulmonary | |||
| > 1 lobe involved | 4 (50) | 12 (44.4) | 1.00 |
| Oxygen saturation at onset, % | 96 (91-99) | 94 (84-100) | .51 |
| Oxygen therapy | 3 (37.5) | 9 (33.3) | 1.00 |
| Management | |||
| Any hospitalization | 8 (100) | 27 (100) | 1.00 |
| Hospitalization > 7 days | 2 (25) | 2 (7.4) | .22 |
| Antibiotics | 8 (100) | 27 (100) | 1.00 |
| Transfusions | 2 (25) | 12 (44.4) | .43 |
| Simple | 1 | 12 | .14 |
| Exchange | 1 | 0 | .14 |
| . | Hydroxyurea, N = 96 . | Placebo, N = 97 . | P . |
|---|---|---|---|
| No. (%) | 8 (8.3) | 27 (27.8) | |
| Median age at event, mo (range) | 26 (15-30) | 27 (12-39) | .67 |
| Median visit week (range) | 46 (2-80) | 55 (0-99) | .22 |
| Associated symptoms | |||
| Fever | 7 (87.5) | 25 (92.6) | .55 |
| Dactylitis | 0 | 1 (3.7) | 1.00 |
| Pain | 4 (50) | 7 (25.9) | .23 |
| Absolute neutrophil count, < 0.5 × 109/L | 0 | 9 (33.3) | .08 |
| Sepsis | 0 | 1 (3.7) | 1.00 |
| Pulmonary | |||
| > 1 lobe involved | 4 (50) | 12 (44.4) | 1.00 |
| Oxygen saturation at onset, % | 96 (91-99) | 94 (84-100) | .51 |
| Oxygen therapy | 3 (37.5) | 9 (33.3) | 1.00 |
| Management | |||
| Any hospitalization | 8 (100) | 27 (100) | 1.00 |
| Hospitalization > 7 days | 2 (25) | 2 (7.4) | .22 |
| Antibiotics | 8 (100) | 27 (100) | 1.00 |
| Transfusions | 2 (25) | 12 (44.4) | .43 |
| Simple | 1 | 12 | .14 |
| Exchange | 1 | 0 | .14 |
P values for categorical variables were derived from the Fisher exact test. P values for continuous variables were derived from the Wilcoxon rank-sum test.