Examples of targets of miRNAs abnormally expressed in AML
| MicroRNA . | Target . | Target gene function . |
|---|---|---|
| Let-7a | RAS | Small GTPase involved in the regulation of cell proliferation, survival, and apoptosis |
| miR-10a | HOXA1 | Homeodomain transcription factor with a role in regulating definitive hematopoiesis |
| miR-17–5p, miR-20a, miR-106a | AML1 | DNA binding subunit of the hematopoietic transcription factor CBF, controlling multiple genes involved in myeloid differentiation |
| miR-130a | MAFB | Transcription factor involved in the activation of GPII8, a key protein for platelet physiology |
| miR-223, miR-107 | NFI-A | Transcription factor known to regulate genes involved in cell proliferation |
| miR-221 and miR-222 | c-Kit | Transmembrane tyrosine-kinase receptor for stem cell factor, required for normal hematopoiesis |
| MicroRNA . | Target . | Target gene function . |
|---|---|---|
| Let-7a | RAS | Small GTPase involved in the regulation of cell proliferation, survival, and apoptosis |
| miR-10a | HOXA1 | Homeodomain transcription factor with a role in regulating definitive hematopoiesis |
| miR-17–5p, miR-20a, miR-106a | AML1 | DNA binding subunit of the hematopoietic transcription factor CBF, controlling multiple genes involved in myeloid differentiation |
| miR-130a | MAFB | Transcription factor involved in the activation of GPII8, a key protein for platelet physiology |
| miR-223, miR-107 | NFI-A | Transcription factor known to regulate genes involved in cell proliferation |
| miR-221 and miR-222 | c-Kit | Transmembrane tyrosine-kinase receptor for stem cell factor, required for normal hematopoiesis |