Myeloid maturation in bone marrow
. | Myeloblast . | Neutrophil maturation, % of all counted cells . | Monocyte . | Lymphocyte . | |||
---|---|---|---|---|---|---|---|
Promyelocyte . | Myelocyte . | Metamyelocyte . | Segmented . | ||||
Wt | 4 ± 1 | 2 ± 0.3 | 12 ± 1 | 12 ± 2 | 31 ± 4 | 6 ± 1 | 21 ± 5 |
Gfi1−/− | 4 ± 1 | 0.2 ± 0.2 | 4 ± 1* | 2 ± 1* | 2 ± 2* | 54 ± 12* | 10 ± 2* |
Gfi136N/36N | 2 ± 2 | 3 ± 1 | 6 ± 2 | 10 ± 2 | 25 ± 3 | 19 ± 3 | 31 ± 3 |
Gfi136S/36S | 2 ± 1 | 1 ± 1 | 14 ± 7 | 10 ± 1 | 16 ± 5 | 14 ± 3 | 37 ± 3 |
. | Myeloblast . | Neutrophil maturation, % of all counted cells . | Monocyte . | Lymphocyte . | |||
---|---|---|---|---|---|---|---|
Promyelocyte . | Myelocyte . | Metamyelocyte . | Segmented . | ||||
Wt | 4 ± 1 | 2 ± 0.3 | 12 ± 1 | 12 ± 2 | 31 ± 4 | 6 ± 1 | 21 ± 5 |
Gfi1−/− | 4 ± 1 | 0.2 ± 0.2 | 4 ± 1* | 2 ± 1* | 2 ± 2* | 54 ± 12* | 10 ± 2* |
Gfi136N/36N | 2 ± 2 | 3 ± 1 | 6 ± 2 | 10 ± 2 | 25 ± 3 | 19 ± 3 | 31 ± 3 |
Gfi136S/36S | 2 ± 1 | 1 ± 1 | 14 ± 7 | 10 ± 1 | 16 ± 5 | 14 ± 3 | 37 ± 3 |
Quantification of the different cell types according to their morphology enumerated from bone marrow cytospins of the indicated mouse strains (n = 3 for all genotypes).
Significant difference to wt mouse strain.