Multivariate analyses of elevated EBV antibody titer and low antibody ratio of EBNA-1/EBNA-2 and risk of EBV+ vs EBV− Hodgkin lymphoma
| Antibody . | Referent . | EBV+ HL cases vs EBV− HL cases* . | EBV+ HL cases vs EBV− HL cases† . |
|---|---|---|---|
| VCA (IgG ≥ 1:2560)‡ | < 1:2560 | 1.3 (0.4-4.2) | 0.95 (0.3-3.3) |
| EA complex (≥ 1: 40)‡ | < 1:40 | 1.6 (0.5-5.1) | 1.2 (0.4-4.2) |
| EBNA-1 (≥ 1:1280)‡ | < 1:1280 | 1.1 (0.2-6.5) | NA |
| EBNA-2 (≥ 1: 80)‡ | < 1:80 | 0.61 (0.2-2.4) | NA |
| EBNA-1/EBNA-2 ratio (≤ 1.0) | > 1.0 | NA | 14.2 (2.7-74.2) |
| Antibody . | Referent . | EBV+ HL cases vs EBV− HL cases* . | EBV+ HL cases vs EBV− HL cases† . |
|---|---|---|---|
| VCA (IgG ≥ 1:2560)‡ | < 1:2560 | 1.3 (0.4-4.2) | 0.95 (0.3-3.3) |
| EA complex (≥ 1: 40)‡ | < 1:40 | 1.6 (0.5-5.1) | 1.2 (0.4-4.2) |
| EBNA-1 (≥ 1:1280)‡ | < 1:1280 | 1.1 (0.2-6.5) | NA |
| EBNA-2 (≥ 1: 80)‡ | < 1:80 | 0.61 (0.2-2.4) | NA |
| EBNA-1/EBNA-2 ratio (≤ 1.0) | > 1.0 | NA | 14.2 (2.7-74.2) |
Data are RR (95% CI).
NA indicates not applicable.
Unconditional logistic regression with mutual control for antibodies to VCA, EA complex, EBNA-1, EBNA-2, and adjusted for age, sex, race, year of serum collection, and histology.
Unconditional logistic regression with mutual control for antibodies to VCA, EA complex, EBNA-1/EBNA-2 ratio ≤ 1.0, and adjusted for age, sex, race, year of serum collection, and histology.
Elevated titer levels.