Comparison of cases and controls in terms of exposure to vaccination
| Exposure and time window before the index date . | Cases (n = 198) . | Controls (n = 878) . | Crude ORs (95% CI) . | Adjusted ORs (95% CI)† . |
|---|---|---|---|---|
| Any vaccine, n (%) | ||||
| 12 mo | 66 (33.3) | 303 (34.5) | 1.0 (0.7-1.4) | 1.0 (0.7, 1.4) |
| Without dates of vaccination | 5 (2.5) | 24 (2.7) | 1.0 (0.4-2.7) | 1.0 (0.4, 2.8) |
| No exposure | 127 (64.1) | 551 (62.8) | 1 | 1 |
| 6 mo | 42 (21.2) | 177 (20.2) | 1.1 (0.7-1.7) | 1.1 (0.7, 1.7) |
| Without dates of vaccination | 6 (3.0) | 24 (2.7) | 1.2 (0.5-3.2) | 1.3 (0.5, 3.2) |
| No exposure | 150 (75.8) | 677 (77.1) | 1 | 1 |
| 2 mo | 17 (8.6) | 62 (7.1) | 1.3 (0.7-2.4) | 1.3 (0.7, 2.3) |
| Without dates of vaccination* | 6 (3.0) | 24 (2.7) | ||
| No exposure | 175 (88.4) | 792 (90.2) | 1 | 1 |
| Influenza vaccine, n (%) | ||||
| 12 mo | 43 (21.7) | 242 (27.6) | 0.7 (0.5-1.1) | 0.7 (0.5-1.1)‡ |
| Without dates of vaccination | 1 (0.5) | 9 (1.0) | 0.5 (0.1-4.1) | 0.5 (0.1-4.4)‡ |
| No exposure | 154 (77.8) | 627 (71.4) | 1 | 1 |
| 6 mo | 28 (14.1) | 133 (15.1) | 0.9 (0.6-1.6) | 0.9 (0.6-1.6)‡ |
| Without dates of vaccination | 2 (1.0) | 9 (1.0) | 1.1 (0.2-5.2) | 1.2 (0.3-6.0)‡ |
| No exposure | 168 (84.8) | 736 (83.8) | 1 | 1 |
| 2 mo | 9 (4.5) | 43 (4.9) | 1.0 (0.4-2.1) | 0.9 (0.4-2.1) |
| Without dates of vaccination* | 2 (1.0) | 9 (1.0) | ||
| No exposure | 187 (94.4) | 826 (94.1) | 1 | 1 |
| DTPP vaccine, n (%) | ||||
| 12 mo | 18 (9.1) | 62 (7.1) | 1.3 (0.8-2.3) | 1.4 (0.8-2.4)§ |
| Without dates of vaccination | 3 (1.5) | 13 (1.5) | 1.2 (0.3-4.1) | 1.1 (0.3-4.1)§ |
| No exposure | 177 (89.4) | 803 (91.5) | 1 | 1 |
| 6 mo | 10 (5.1) | 34 (3.9) | 1.3 (0.6-2.7) | 1.3 (0.6-2.7)§ |
| Without dates of vaccination | 3 (1.5) | 13 (1.5) | 1.2 (0.3-4.1) | 1.1 (0.3-4.0)§ |
| No exposure | 185 (93.4) | 831 (94.6) | 1 | 1 |
| 2 mo | 4 (2.0)* | 13 (1.5)* | 1.5 (0.5-4.6) | 1.5 (0.5-4.5) |
| Without dates of vaccination* | 3 (1.5) | 13 (1.5) | ||
| No exposure | 191 (96.5) | 852 (97.0) | ||
| Exposure and time window before the index date . | Cases (n = 198) . | Controls (n = 878) . | Crude ORs (95% CI) . | Adjusted ORs (95% CI)† . |
|---|---|---|---|---|
| Any vaccine, n (%) | ||||
| 12 mo | 66 (33.3) | 303 (34.5) | 1.0 (0.7-1.4) | 1.0 (0.7, 1.4) |
| Without dates of vaccination | 5 (2.5) | 24 (2.7) | 1.0 (0.4-2.7) | 1.0 (0.4, 2.8) |
| No exposure | 127 (64.1) | 551 (62.8) | 1 | 1 |
| 6 mo | 42 (21.2) | 177 (20.2) | 1.1 (0.7-1.7) | 1.1 (0.7, 1.7) |
| Without dates of vaccination | 6 (3.0) | 24 (2.7) | 1.2 (0.5-3.2) | 1.3 (0.5, 3.2) |
| No exposure | 150 (75.8) | 677 (77.1) | 1 | 1 |
| 2 mo | 17 (8.6) | 62 (7.1) | 1.3 (0.7-2.4) | 1.3 (0.7, 2.3) |
| Without dates of vaccination* | 6 (3.0) | 24 (2.7) | ||
| No exposure | 175 (88.4) | 792 (90.2) | 1 | 1 |
| Influenza vaccine, n (%) | ||||
| 12 mo | 43 (21.7) | 242 (27.6) | 0.7 (0.5-1.1) | 0.7 (0.5-1.1)‡ |
| Without dates of vaccination | 1 (0.5) | 9 (1.0) | 0.5 (0.1-4.1) | 0.5 (0.1-4.4)‡ |
| No exposure | 154 (77.8) | 627 (71.4) | 1 | 1 |
| 6 mo | 28 (14.1) | 133 (15.1) | 0.9 (0.6-1.6) | 0.9 (0.6-1.6)‡ |
| Without dates of vaccination | 2 (1.0) | 9 (1.0) | 1.1 (0.2-5.2) | 1.2 (0.3-6.0)‡ |
| No exposure | 168 (84.8) | 736 (83.8) | 1 | 1 |
| 2 mo | 9 (4.5) | 43 (4.9) | 1.0 (0.4-2.1) | 0.9 (0.4-2.1) |
| Without dates of vaccination* | 2 (1.0) | 9 (1.0) | ||
| No exposure | 187 (94.4) | 826 (94.1) | 1 | 1 |
| DTPP vaccine, n (%) | ||||
| 12 mo | 18 (9.1) | 62 (7.1) | 1.3 (0.8-2.3) | 1.4 (0.8-2.4)§ |
| Without dates of vaccination | 3 (1.5) | 13 (1.5) | 1.2 (0.3-4.1) | 1.1 (0.3-4.1)§ |
| No exposure | 177 (89.4) | 803 (91.5) | 1 | 1 |
| 6 mo | 10 (5.1) | 34 (3.9) | 1.3 (0.6-2.7) | 1.3 (0.6-2.7)§ |
| Without dates of vaccination | 3 (1.5) | 13 (1.5) | 1.2 (0.3-4.1) | 1.1 (0.3-4.0)§ |
| No exposure | 185 (93.4) | 831 (94.6) | 1 | 1 |
| 2 mo | 4 (2.0)* | 13 (1.5)* | 1.5 (0.5-4.6) | 1.5 (0.5-4.5) |
| Without dates of vaccination* | 3 (1.5) | 13 (1.5) | ||
| No exposure | 191 (96.5) | 852 (97.0) | ||
The numbers exposed were too small to calculate meaningful ORs.
ORs were adjusted for: family history of autoimmune disorders (yes/no/unknown/missing) and systemic NSAID(s) in the 12 mo before the index date (yes/no).
ORs were also adjusted for vaccination with any vaccine other than influenza in the 24 mo before the index date (yes/no).
ORs were also adjusted for vaccination with any vaccine other than DTPP in the 24 mo before the index date (yes/no).