Table 1 Changes in objective signs... | American Society of Hematology

Table 1

Changes in objective signs during the evolution of the sickle cell painful crisis

Podromal phase	Initial phase	Established phase	Resolving phase
Decreasing	Decreasing	Peak	Peak
RBC deformability	RBC deformability	Temperature	Fibrinogen
	Platelets	WBC count	Orosomucoid
Increasing		Dense cells	ESR
Dense RBC	Increasing	ISC
	Temperature	RDW	Decreasing
	WBC count	HDW	Temperature
	Dense cells	Reticuloytes	WBC count
	ISC	LDH	Dense cells
	RDW	CRP	ISC
	HDW	SAA	RDW
	ESR		HDW
	LDH	Nadir	CRP
	CRP	RBC deformability
	Fibrinogen	Hb	Increasing
	Orosomucoid		RBC deformability
	SAA	Increasing	Plasma viscosity
		Fibrinogen	Platelets
		Orosomucoid
		Plasma viscosity
		ESR

Podromal phase	Initial phase	Established phase	Resolving phase
Decreasing	Decreasing	Peak	Peak
RBC deformability	RBC deformability	Temperature	Fibrinogen
	Platelets	WBC count	Orosomucoid
Increasing		Dense cells	ESR
Dense RBC	Increasing	ISC
	Temperature	RDW	Decreasing
	WBC count	HDW	Temperature
	Dense cells	Reticuloytes	WBC count
	ISC	LDH	Dense cells
	RDW	CRP	ISC
	HDW	SAA	RDW
	ESR		HDW
	LDH	Nadir	CRP
	CRP	RBC deformability
	Fibrinogen	Hb	Increasing
	Orosomucoid		RBC deformability
	SAA	Increasing	Plasma viscosity
		Fibrinogen	Platelets
		Orosomucoid
		Plasma viscosity
		ESR

Parameters shown are those reported at least twice by different investigators.

ISC indicates irreversibly sickled cells; WBC, white blood cells; RDW, red cell distribution width; HDW, hemoglobin distribution width; ESR, erythrocyte sedimentation rate; LDH, lactate dehydrogenase; CRP, C-reactive protein; and SAA, serum amyloid A.

Data from Ballas with permission.⁴⁴

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