A partial compilation of the processes outlined in the text
| Process/alterations . | Malignant phenotypes . |
|---|---|
| Genetic alteration in multilineage progenitor | |
| Rearrangements of PDGFRA, PDGFRB, and FGFR1 | Myeloproliferative neoplasm |
| T-cell lymphoblastic lymphoma, AML | |
| Mutations of DNMT3A and TET2 | Angioimmunoblastic T-cell lymphoma |
| MDS | |
| Mutations of TLN2, EP300, and KLHL6 | FL |
| B-lineage priming of multilineage progenitor | B-cell chronic lymphocytic leukemia |
| TCR rearrangement in multilineage progenitor | MLL-translocated AML |
| Coexisting B-lineage lymphomas | |
| Same Ig rearrangement | Multiple phenotypes |
| Composite lymphomas | |
| Different Ig rearrangement | Multiple phenotypes |
| Lineage switching after Ig rearrangement | |
| BCR-ABL1 | Chronic myeloid leukemia myeloid blast crisis |
| CD19-Cre/Pax5fl/− murine B cells | T-cell and myeloid potential in vivo |
| CALM-AF10 murine model | AML |
| B220+ tumor-propagating cells | |
| BCL2-IGH | Histiocytic/dendritic cell neoplasm |
| FL | |
| Loss of B-lineage markers after Ig rearrangement | Hodgkin lymphoma |
| Process/alterations . | Malignant phenotypes . |
|---|---|
| Genetic alteration in multilineage progenitor | |
| Rearrangements of PDGFRA, PDGFRB, and FGFR1 | Myeloproliferative neoplasm |
| T-cell lymphoblastic lymphoma, AML | |
| Mutations of DNMT3A and TET2 | Angioimmunoblastic T-cell lymphoma |
| MDS | |
| Mutations of TLN2, EP300, and KLHL6 | FL |
| B-lineage priming of multilineage progenitor | B-cell chronic lymphocytic leukemia |
| TCR rearrangement in multilineage progenitor | MLL-translocated AML |
| Coexisting B-lineage lymphomas | |
| Same Ig rearrangement | Multiple phenotypes |
| Composite lymphomas | |
| Different Ig rearrangement | Multiple phenotypes |
| Lineage switching after Ig rearrangement | |
| BCR-ABL1 | Chronic myeloid leukemia myeloid blast crisis |
| CD19-Cre/Pax5fl/− murine B cells | T-cell and myeloid potential in vivo |
| CALM-AF10 murine model | AML |
| B220+ tumor-propagating cells | |
| BCL2-IGH | Histiocytic/dendritic cell neoplasm |
| FL | |
| Loss of B-lineage markers after Ig rearrangement | Hodgkin lymphoma |
If multiple phenotypes are listed under a single alteration, it indicates that they can coexist within the same person. Coexisting B-lineage malignancies may harbor the same immunoglobulin (Ig) rearrangement or different Ig rearrangements. Composite B-cell malignancies are a subset of the former found within the same tumor mass. Histiocytic/dendritic cell neoplasms have been observed with a variety of B-cell and T-cell malignancies in addition to follicular lymphoma.