Peripheral blood cell counts in reconstituted mice
| Retroviral construct(s); phenotype . | No. of mice analyzed . | WBC, × 109/L . | RBC, × 109/L . | Hematocrit, % . | Platelets, × 109/L . |
|---|---|---|---|---|---|
| Bex;Vex | 13 | 6.39 ± 4.00 | 8.11 ± 2.22 | 34.6 ± 10.0 | 580 ± 295 |
| RE-nonleukemic | 5 | 6.43 ± 4.00 | 8.15 ± 2.12 | 37.2 ± 3.2 | 644 ± 333 |
| D814V-MPN | 3 | > 200* | 4.30 ± 1.28* | 23.4 ± 10.2 | 686 ± 328 |
| D814V-T-ALL | 3 | 3.41 ± 1.72 | 9.90 ± 1.68 | 45.8 ± 11.8 | 360 ± 228 |
| D814V-B-ALL | 1 | 12.34 | 5.07 | 20.9 | 191 |
| T417IΔ418–419-B-ALL | 1 | 80.29 | 6.51 | 29.7 | 270 |
| RE;T417IΔ418–419-AML | 11 | 15.59 ± 19.83 | 2.77 ± 2.12* | 15.6 ± 11.1* | 157 ± 151* |
| RE;D814V-AML | 8 | 11.39 ± 11.55 | 7.11 ± 2.37 | 30.9 ± 9.8 | 142 ± 97* |
| RE;D814V-MPN | 6 | 22.14 ± 15.89* | 3.78 ± 1.47* | 16.9 ± 9.4* | 132 ± 21* |
| RE;D814V-B-ALL | 4 | 19.94 ± 29.64 | 7.20 ± 2.81 | 29.6 ± 8.0 | 140 ± 84* |
| Retroviral construct(s); phenotype . | No. of mice analyzed . | WBC, × 109/L . | RBC, × 109/L . | Hematocrit, % . | Platelets, × 109/L . |
|---|---|---|---|---|---|
| Bex;Vex | 13 | 6.39 ± 4.00 | 8.11 ± 2.22 | 34.6 ± 10.0 | 580 ± 295 |
| RE-nonleukemic | 5 | 6.43 ± 4.00 | 8.15 ± 2.12 | 37.2 ± 3.2 | 644 ± 333 |
| D814V-MPN | 3 | > 200* | 4.30 ± 1.28* | 23.4 ± 10.2 | 686 ± 328 |
| D814V-T-ALL | 3 | 3.41 ± 1.72 | 9.90 ± 1.68 | 45.8 ± 11.8 | 360 ± 228 |
| D814V-B-ALL | 1 | 12.34 | 5.07 | 20.9 | 191 |
| T417IΔ418–419-B-ALL | 1 | 80.29 | 6.51 | 29.7 | 270 |
| RE;T417IΔ418–419-AML | 11 | 15.59 ± 19.83 | 2.77 ± 2.12* | 15.6 ± 11.1* | 157 ± 151* |
| RE;D814V-AML | 8 | 11.39 ± 11.55 | 7.11 ± 2.37 | 30.9 ± 9.8 | 142 ± 97* |
| RE;D814V-MPN | 6 | 22.14 ± 15.89* | 3.78 ± 1.47* | 16.9 ± 9.4* | 132 ± 21* |
| RE;D814V-B-ALL | 4 | 19.94 ± 29.64 | 7.20 ± 2.81 | 29.6 ± 8.0 | 140 ± 84* |
Peripheral blood was collected by cardiac puncture from nonleukemic or moribund mice. A 50-μL sample was subjected to complete blood cell counting using a Hemavet 950 instrument. Data are mean ± SD.
P < .01, compared with Bex;Vex controls (unpaired t test).