Dogs treated with 211At-anti-CD45 mAb without marrow grafts
| Dog ID . | Age, mo . | Weight, kg . | 211At, μCi/kg . | 211At, MBq/kg . | Survival, wk . | Cause of death . | Pathology . |
|---|---|---|---|---|---|---|---|
| H313 | 9 | 5.8 | 100 | 3.7 | 53 | End of study | Normal* |
| H297 | 7 | 7.6 | 196 | 7.4 | 54 | End of study | Normal* |
| H248 | 7 | 13.0 | 320 | 11.8 | 54 | End of study | Normal* |
| H213 | 6 | 9.6 | 405 | 15.2 | 49 | Increasing transfusion requirements | Histologic changes consistent with hemolytic anemia† |
| H290 | 7 | 8.0 | 458 | 17.0 | 20 | Liver failure with ascites | Histologic changes in the liver‡ |
| H289 | 11 | 7.2 | 618 | 22.9 | 17 | Liver failure with ascites | Histologic changes in the liver‡ |
| Dog ID . | Age, mo . | Weight, kg . | 211At, μCi/kg . | 211At, MBq/kg . | Survival, wk . | Cause of death . | Pathology . |
|---|---|---|---|---|---|---|---|
| H313 | 9 | 5.8 | 100 | 3.7 | 53 | End of study | Normal* |
| H297 | 7 | 7.6 | 196 | 7.4 | 54 | End of study | Normal* |
| H248 | 7 | 13.0 | 320 | 11.8 | 54 | End of study | Normal* |
| H213 | 6 | 9.6 | 405 | 15.2 | 49 | Increasing transfusion requirements | Histologic changes consistent with hemolytic anemia† |
| H290 | 7 | 8.0 | 458 | 17.0 | 20 | Liver failure with ascites | Histologic changes in the liver‡ |
| H289 | 11 | 7.2 | 618 | 22.9 | 17 | Liver failure with ascites | Histologic changes in the liver‡ |
The total dose of anti-CD45 mAb was 0.5 mg/kg, whereof 10% was injected as unlabeled anti-CD45 mAb 1 hour before treatment with the radioimmunoconjugate.
No macroscopic or histologic evidence of radioactivity induced organ toxicity.
H213 was a pyruvate kinase deficiency carrier that developed increasing transfusion requirements during follow-up.
Histologic examination of liver tissue revealed clusters of iron-laden macrophages scattered throughout the liver acinus and perivenular area.