Table 1

Expression and function of P1 and P2 receptor subtypes in normal human hematopoietic cells

Cell typeReceptor subtypeResponses/functionsReferences
CD34+ cells P2X1, P2X2, P2X3, P2X4, P2X5, P2X6, P2X7 In vivo and in vitro proliferation, chemotaxis, cell adhesion* 58,83  
P2Y1, P2Y2, P2Y11, P2Y12, P2Y13 
DCs A1 IL-12 inhibition 84  
 A2A  84,85  
 A3  86,87  
  Chemotaxis* 87  
 P2Y1 Chemotaxis 88  
 P2Y2  31,88  
 P2Y4 CXCL8 88  
 P2Y6 IL-8, maturation of moncytes derived DCs, chemotaxis 88,89  
 P2Y11  88,90  
 P2X1, P2X4 IL-1β secretion 88  
 P2X7  88,91  
Plasmacytoid DCs A1 Chemotaxis 92  
A2A Down-regulation IL-6, IL-12, IFN-α 92  
Eosinophils A3 Apoptosis 93  
 P2X1, P2X4, P2X7 Chemotaxis 94  
 P2Y1  94  
 P2Y2  31,94  
 P2Y4, P2Y6, P2Y11  94  
  CD11 up-regulation, ROIs, IL-8 and ECP secretion* 94,95  
B lymphocytes P2X1, P2X2, P2X4  83,96  
P2X7 Shedding of L-selectin and CD23 83,96  
TCD4+ lymphocytes A2A Inhibition of proliferation 97  
TCD8+ lymphocytes A2A Inhibition of cytotoxicity 97  
T lymphocytes A1  98  
 A2A Anergy, induction of Treg 99  
 A2B  100  
 A3  87  
 P2X1, P2X4, P2X7  83  
 P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13  83  
Macrophages A1 Enhancement of Fcγ receptor-mediated phagocytosis 101  
A2A IL-4-induced TIMP-1 secretory, inhibitory IL-12, NO, MIP-1α, TNF-α 102  
 decrease of Fcγ receptor-mediated phagocytosis  
A2B IL-4-induced TIMP-1 secretory, inhibitory IL-12, NO, MIP-1α, TNF-α 102  
A3  102  
P2X1, P2X4, P2X7 Polycarion formation, IL-1β secretion 103  
P2Y1, P2Y4, P2Y6  104  
P2Y2 Enhancement of ROI production 104,105  
Mast cells A1 Activation of mast cell degranulation 106  
 A2A Potentiation of FcϵRI-induced degranulation 107  
 A2B Inhibition of mast cell degranulation 106  
 P2X1, P2X4  108  
 P2Y1, P2Y2, P2Y11, P2Y12, P2Y13  108  
Monocytes A2A Inhibition of TNF-α, IL-6, IL-8, IL-12 102  
 Stimulation of IL-10 secretion 102  
A3 Inhibition ROIs production 109  
P2X1, P2X4, P2X7  83,110  
P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13  83,104  
Neutrophils A1 Increase of chemotaxis 102  
  Increase of FcγR-mediated phagocytosis and ROI production 101  
 A2A Inhibition of FcγR-mediated phagocytosis and ROI production 101  
  Inhibition of cell adhesion 102  
 A2B  100  
 A3 Degranulation and ROI production inhibition, chemotaxis 111  
 P2X1 Chemotaxis 112  
 P2X7  110  
 P2Y2 Chemotaxis 111  
 P2Y4, P2Y6, P2Y11  103,111  
NK cells A2A Inhibition of cytotoxicity 97  
P2X1, P2X4, P2X5, P2X6, P2X7  110,113  
P2Y1, P2Y2, P2Y4, P2Y6, , P2Y12, P2Y13, P2Y14  113  
P2Y11 Inhibition of CX3CL1-elicited NK-mediated killing 113  
Platelets A2A Antiaggregation 114  
P2Y1 Aggregation and shape changes 114  
P2Y12 Aggregation, phosphatidylserine exposure 115  
P2X1 Transient shape changes 109  
P2X7   
Red blood cells P2X2   
 P2X7 Phosphatidylserine exposure 116  
 P2Y1  116  
Cell typeReceptor subtypeResponses/functionsReferences
CD34+ cells P2X1, P2X2, P2X3, P2X4, P2X5, P2X6, P2X7 In vivo and in vitro proliferation, chemotaxis, cell adhesion* 58,83  
P2Y1, P2Y2, P2Y11, P2Y12, P2Y13 
DCs A1 IL-12 inhibition 84  
 A2A  84,85  
 A3  86,87  
  Chemotaxis* 87  
 P2Y1 Chemotaxis 88  
 P2Y2  31,88  
 P2Y4 CXCL8 88  
 P2Y6 IL-8, maturation of moncytes derived DCs, chemotaxis 88,89  
 P2Y11  88,90  
 P2X1, P2X4 IL-1β secretion 88  
 P2X7  88,91  
Plasmacytoid DCs A1 Chemotaxis 92  
A2A Down-regulation IL-6, IL-12, IFN-α 92  
Eosinophils A3 Apoptosis 93  
 P2X1, P2X4, P2X7 Chemotaxis 94  
 P2Y1  94  
 P2Y2  31,94  
 P2Y4, P2Y6, P2Y11  94  
  CD11 up-regulation, ROIs, IL-8 and ECP secretion* 94,95  
B lymphocytes P2X1, P2X2, P2X4  83,96  
P2X7 Shedding of L-selectin and CD23 83,96  
TCD4+ lymphocytes A2A Inhibition of proliferation 97  
TCD8+ lymphocytes A2A Inhibition of cytotoxicity 97  
T lymphocytes A1  98  
 A2A Anergy, induction of Treg 99  
 A2B  100  
 A3  87  
 P2X1, P2X4, P2X7  83  
 P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13  83  
Macrophages A1 Enhancement of Fcγ receptor-mediated phagocytosis 101  
A2A IL-4-induced TIMP-1 secretory, inhibitory IL-12, NO, MIP-1α, TNF-α 102  
 decrease of Fcγ receptor-mediated phagocytosis  
A2B IL-4-induced TIMP-1 secretory, inhibitory IL-12, NO, MIP-1α, TNF-α 102  
A3  102  
P2X1, P2X4, P2X7 Polycarion formation, IL-1β secretion 103  
P2Y1, P2Y4, P2Y6  104  
P2Y2 Enhancement of ROI production 104,105  
Mast cells A1 Activation of mast cell degranulation 106  
 A2A Potentiation of FcϵRI-induced degranulation 107  
 A2B Inhibition of mast cell degranulation 106  
 P2X1, P2X4  108  
 P2Y1, P2Y2, P2Y11, P2Y12, P2Y13  108  
Monocytes A2A Inhibition of TNF-α, IL-6, IL-8, IL-12 102  
 Stimulation of IL-10 secretion 102  
A3 Inhibition ROIs production 109  
P2X1, P2X4, P2X7  83,110  
P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13  83,104  
Neutrophils A1 Increase of chemotaxis 102  
  Increase of FcγR-mediated phagocytosis and ROI production 101  
 A2A Inhibition of FcγR-mediated phagocytosis and ROI production 101  
  Inhibition of cell adhesion 102  
 A2B  100  
 A3 Degranulation and ROI production inhibition, chemotaxis 111  
 P2X1 Chemotaxis 112  
 P2X7  110  
 P2Y2 Chemotaxis 111  
 P2Y4, P2Y6, P2Y11  103,111  
NK cells A2A Inhibition of cytotoxicity 97  
P2X1, P2X4, P2X5, P2X6, P2X7  110,113  
P2Y1, P2Y2, P2Y4, P2Y6, , P2Y12, P2Y13, P2Y14  113  
P2Y11 Inhibition of CX3CL1-elicited NK-mediated killing 113  
Platelets A2A Antiaggregation 114  
P2Y1 Aggregation and shape changes 114  
P2Y12 Aggregation, phosphatidylserine exposure 115  
P2X1 Transient shape changes 109  
P2X7   
Red blood cells P2X2   
 P2X7 Phosphatidylserine exposure 116  
 P2Y1  116  

ROI indicates reactive oxygen intermediate; ECP, eosinophil cationic protein; and TIMP-1, tissue inhibitor of matrix metalloproteinase-1.

*

Responses/functions that have been documented in a cell type but not linked to a specific receptor subtype.

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