Table 1

Modified ACE-27 comorbidity rating scheme used in SHIELD study

Comorbidity scaleGrade 1Grade 2Grade 3Grade 4Grade 5
Instructions:      
    1. Select a grade for each of the systems.      
    2. Press the calculate button to add up the number of individual grades.      
    3. Use the totals to work out which answer to use (frail/not frail).      
        All grade 1 (not frail)      
        All grade 2 or less (not frail)      
        Two grade 3 or higher (not frail)      
        More than three grade 3 or at least one grade 4/5 (“frail”)      
Grade key      
    1. No disability      
    2. Low disability (it does not interfere with normal activities; treatment is optional; very good prognosis)      
    3. Mild disability (it interferes with normal activities; treatment is needed; good prognosis)      
    4. Severe disability (disabling, urgent treatment is needed; poor prognosis)      
    5. Very severe disability (it can be fatal; emergency treatment is needed; danger list)      
System      
    Heart (heart only) ○ ○ ○ ○ ○ 
    Hypertension (hypertension severity is considered) ○ ○ ○ ○ ○ 
    Vascular (both venous and artery districts) ○ ○ ○ ○ ○ 
    Diabetes ○ ○ ○ ○ ○ 
    Respiratory ○ ○ ○ ○ ○ 
    Gastrointestinal ○ ○ ○ ○ ○ 
    Liver ○ ○ ○ ○ ○ 
    Kidney ○ ○ ○ ○ ○ 
    Other genitourinary ○ ○ ○ ○ ○ 
    Bone and muscle ○ ○ ○ ○ ○ 
    Nervous system (central and peripheral, dementia is excluded) ○ ○ ○ ○ ○ 
    Eyes and ENT (eyes, ears, nose, larynx) ○ ○ ○ ○ ○ 
    Endocrine system and metabolism (diabetes excluded) ○ ○ ○ ○ ○ 
Calculate:      
    If “frail,” not eligible for VEPEMB study 1's 2's 3's 4's 5's 
Total ○ ○ ○ ○ ○ 
Comorbidity scaleGrade 1Grade 2Grade 3Grade 4Grade 5
Instructions:      
    1. Select a grade for each of the systems.      
    2. Press the calculate button to add up the number of individual grades.      
    3. Use the totals to work out which answer to use (frail/not frail).      
        All grade 1 (not frail)      
        All grade 2 or less (not frail)      
        Two grade 3 or higher (not frail)      
        More than three grade 3 or at least one grade 4/5 (“frail”)      
Grade key      
    1. No disability      
    2. Low disability (it does not interfere with normal activities; treatment is optional; very good prognosis)      
    3. Mild disability (it interferes with normal activities; treatment is needed; good prognosis)      
    4. Severe disability (disabling, urgent treatment is needed; poor prognosis)      
    5. Very severe disability (it can be fatal; emergency treatment is needed; danger list)      
System      
    Heart (heart only) ○ ○ ○ ○ ○ 
    Hypertension (hypertension severity is considered) ○ ○ ○ ○ ○ 
    Vascular (both venous and artery districts) ○ ○ ○ ○ ○ 
    Diabetes ○ ○ ○ ○ ○ 
    Respiratory ○ ○ ○ ○ ○ 
    Gastrointestinal ○ ○ ○ ○ ○ 
    Liver ○ ○ ○ ○ ○ 
    Kidney ○ ○ ○ ○ ○ 
    Other genitourinary ○ ○ ○ ○ ○ 
    Bone and muscle ○ ○ ○ ○ ○ 
    Nervous system (central and peripheral, dementia is excluded) ○ ○ ○ ○ ○ 
    Eyes and ENT (eyes, ears, nose, larynx) ○ ○ ○ ○ ○ 
    Endocrine system and metabolism (diabetes excluded) ○ ○ ○ ○ ○ 
Calculate:      
    If “frail,” not eligible for VEPEMB study 1's 2's 3's 4's 5's 
Total ○ ○ ○ ○ ○ 

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