Characteristics of early-stage and advanced-stage HL patients
| Characteristic . | Cox-2+ . | Cox-2− . | P . | |
|---|---|---|---|---|
| Early-stage HL | ||||
| Age, y (range) | 31 (10-79) | 31 (12-79) | 31 (10-71) | .82 |
| Age ≥ 50 y, n (%) | 24 (17%) | 6 (13%) | 18 (17%) | .41 |
| Sex, M/F (%) | 77 (54%)/66 (46%) | 24 (52%)/22 (48%) | 53 (55%)/44 (45%) | .78 |
| B symptoms, n (%) | 43 (30%) | 15 (33%) | 28% (29%) | .65 |
| Bulky disease, n (%) | 42 (30%) | 15 (33%) | 27 (28%) | .53 |
| ECOG PS > 1, n (%) | 8 (6%) | 3 (7%) | 5 (5%) | .70 |
| Unfavorable EORTC score, n (%) | 70 (84%) | 27 (77%) | 43 (90%) | .12 |
| RT, n (%) | 95 (66%) | 33 (72%) | 62 (64%) | .35 |
| COX2 staining, n (%) | 46 (32%) | 100% | 0% | — |
| Advanced-stage HL | ||||
| Age, y (range) | 36 (16-83) | 35 (18-83) | 38 (16-81) | .94 |
| Age > 45 y, n (%) | 34 (34%) | 16 (37%) | 18 (32%) | .60 |
| Sex (M/F) | 54 (54%)/45 (45%) | 23 (53%)/20 (46%) | 31 (55%)/25 (45%) | .85 |
| B symptoms, n (%) | 55 (56%) | 25 (58%) | 30% (54%) | .65 |
| Bulky disease, n (%) | 27 (27%) | 11 (26%) | 16 (29%) | .74 |
| ECOG PS > 1, n (%) | 16 (16%) | 8 (19%) | 8 (14%) | .56 |
| IPS > 2, n (%) | 45 (45%) | 22 (51%) | 23 (41%) | .32 |
| RT, n (%) | 29 (30%) | 13 (31%) | 16 (29%) | .80 |
| COX2 staining, n (%) | 43 (43%) | 100% | 0% | — |
| Characteristic . | Cox-2+ . | Cox-2− . | P . | |
|---|---|---|---|---|
| Early-stage HL | ||||
| Age, y (range) | 31 (10-79) | 31 (12-79) | 31 (10-71) | .82 |
| Age ≥ 50 y, n (%) | 24 (17%) | 6 (13%) | 18 (17%) | .41 |
| Sex, M/F (%) | 77 (54%)/66 (46%) | 24 (52%)/22 (48%) | 53 (55%)/44 (45%) | .78 |
| B symptoms, n (%) | 43 (30%) | 15 (33%) | 28% (29%) | .65 |
| Bulky disease, n (%) | 42 (30%) | 15 (33%) | 27 (28%) | .53 |
| ECOG PS > 1, n (%) | 8 (6%) | 3 (7%) | 5 (5%) | .70 |
| Unfavorable EORTC score, n (%) | 70 (84%) | 27 (77%) | 43 (90%) | .12 |
| RT, n (%) | 95 (66%) | 33 (72%) | 62 (64%) | .35 |
| COX2 staining, n (%) | 46 (32%) | 100% | 0% | — |
| Advanced-stage HL | ||||
| Age, y (range) | 36 (16-83) | 35 (18-83) | 38 (16-81) | .94 |
| Age > 45 y, n (%) | 34 (34%) | 16 (37%) | 18 (32%) | .60 |
| Sex (M/F) | 54 (54%)/45 (45%) | 23 (53%)/20 (46%) | 31 (55%)/25 (45%) | .85 |
| B symptoms, n (%) | 55 (56%) | 25 (58%) | 30% (54%) | .65 |
| Bulky disease, n (%) | 27 (27%) | 11 (26%) | 16 (29%) | .74 |
| ECOG PS > 1, n (%) | 16 (16%) | 8 (19%) | 8 (14%) | .56 |
| IPS > 2, n (%) | 45 (45%) | 22 (51%) | 23 (41%) | .32 |
| RT, n (%) | 29 (30%) | 13 (31%) | 16 (29%) | .80 |
| COX2 staining, n (%) | 43 (43%) | 100% | 0% | — |
— indicates not applicable.