Table 4

Variable selected model by Akaike information criteria

VariableAllelesβ95% CIP
Females (n = 1975)     
 Age (per 5 y)  −0.0275 –0.0476 to −0.00732 .0076 
 Hypertension (%)  0.0849 –0.0122 to 0.182 .086 
 Diabetes (%)  0.206 0.0393 to 0.373 .015 
 Obesity (%)  −0.0684 –0.164 to 0.0268 .16 
 WBC (× 109/L)  0.0448 0.0240 to 0.0657 <.001 
 Platelets (× 109/L)  −0.00421 –0.00476 to −0.00366 <.001 
 Fibrinogen (mg/dL)  0.00121 0.000692 to 0.00173 <.001 
 Oral contraceptive (%)  0.271 0.109 to 0.433 .0010 
 Antithrombotics (%)  0.132 –0.00214 to 0.266 .054 
 Antihypertensive (%)  −0.114 –0.219 to −0.00860 .034 
 rs342293 C/G vs C/C 0.0978 0.0145 to 0.181 .021 
 rs342293 G/G vs C/C 0.236 0.132 to 0.340 <.001 
 rs10506328 C/A vs C/C 0.0565 –0.0160 to 0.129 .13 
 rs12485738 A/A vs G/G 0.169 0.0642 to 0.274 .0016 
 rs2138852 T/C vs T/T −0.0651 –0.153 to 0.0224 .14 
 rs2138852 C/C vs T/T −0.185 –0.287 to −0.0836 <.001 
 rs10076782 G/A vs G/G 0.0553 –0.0200 to 0.131 .15 
 rs11734132 G/C vs G/G −0.0607 –0.141 to 0.0195 .14 
 rs12969657 T/C vs T/T −0.128 –0.216 to −0.0396 .0045 
 rs12969657 C/C vs T/T −0.105 –0.210 to −0.00119 .047 
 rs13042885 C/T vs C/C −0.0860 –0.162 to −0.00948 .028 
 rs13042885 T/T vs C/C −0.150 –0.298 to −0.00252 .046 
 rs2950390 T/T vs C/C −0.0818 –0.193 to 0.0296 .15 
 rs4812048 C/T vs C/C −0.0897 –0.172 to −0.00777 .032 
 rs4812048 T/T vs C/C −0.190 –0.420 to 0.0395 .10 
 rs649729 A/T vs A/A 0.100 0.0240 to 0.177 .010 
 rs649729 T/T vs A/A 0.137 0.000939 to 0.273 .048 
 rs7317038 C/T vs C/C −0.0624 –0.136 to 0.0116 .098 
 rs12355784 C/A vs C/C −0.110 –0.197 to −0.0218 .014 
 rs12355784 A/A vs C/C −0.164 –0.267 to −0.0602 .0019 
 rs4951184 T/A vs T/T −0.0667 –0.145 to 0.0120 .096 
 rs4951184 A/A vs T/T −0.232 –0.342 to −0.121 <.001 
 rs7342306 G/A vs G/G 0.0623 –0.0193 to 0.144 .13 
 rs7342306 A/A vs G/G 0.147 0.0381 to 0.255 .0081 
 rs10512628 C/C vs T/T 0.0685 –0.0214 to 0.158 .14 
 rs17397129 A/G vs A/A 0.125 0.0397 to 0.211 .0041 
 rs17397129 G/G vs A/A 0.412 0.103 to 0.720 .0089 
 rs4774471 T/A vs T/T 0.0811 0.00424 to 0.158 .039 
 rs4774471 A/A vs T/T 0.237 0.115 to 0.360 <.001 
 rs6135137 G/A vs G/G 0.0902 0.0163 to 0.164 .017 
 rs17568628 T/C vs T/T 0.264 0.115 to 0.412 <.001 
 rs7961894 T/T vs C/C 0.222 0.134 to 0.311 <.001 
Males (n = 2084)     
 Age (per 5 y)  −0.0345 –0.0529 to −0.0160 <.001 
 Smoking (%)  0.103 0.00940 to 0.196 .031 
 Obesity (%)  0.0864 0.00388 to 0.169 .040 
 WBC (× 109/L)  0.0290 0.0165 to 0.0415 <.001 
 Platelets (× 109/L)  −0.00468 –0.00528 to −0.00408 <.001 
 CRP (mg/L)  −0.00743 –0.0154 to 0.000530 .067 
 Fibrinogen (mg/dL)  0.000881 0.000323 to 0.00144 .0020 
 Aspirin (%)  0.125 0.00380 to 0.247 .043 
 Antilipemic (%)  0.111 –0.000248 to 0.222 .051 
 Diuretics (%)  0.149 –0.00325 to 0.302 .055 
 rs342293 G/G vs C/C 0.172 0.0852 to 0.259 <.001 
 rs10506328 C/A vs C/C 0.138 0.0613 to 0.214 <.001 
 rs10506328 A/A vs C/C 0.171 0.0654 to 0.277 .0015 
 rs12485738 A/A vs G/G 0.116 0.0132 to 0.218 .027 
 rs2138852 T/C vs T/T −0.0741 –0.159 to 0.0103 .085 
 rs2138852 C/C vs T/T −0.180 –0.277 to −0.0823 <.001 
 rs2180748 G/T vs G/G −0.0960 –0.175 to −0.0173 .017 
 rs2180748 T/T vs G/G −0.110 –0.214 to −0.00552 .039 
 rs11734132 G/C vs G/G −0.0665 –0.145 to 0.0116 .095 
 rs11734132 C/C vs G/G −0.188 –0.416 to 0.0405 .11 
 rs13042885 C/T vs C/C −0.0758 –0.150 to −0.00184 .045 
 rs13042885 T/T vs C/C −0.215 –0.352 to −0.0779 .0021 
 rs2950390 T/T vs C/C −0.103 –0.214 to 0.00861 .071 
 rs12355784 A/A vs C/C −0.0651 –0.146 to 0.0153 .11 
 rs4951184 T/A vs T/T −0.0603 –0.136 to 0.0159 .12 
 rs4951184 A/A vs T/T −0.213 –0.322 to −0.104 <.001 
 rs7342306 G/A vs G/G 0.136 0.0560 to 0.215 <.001 
 rs7342306 A/A vs G/G 0.106 0.00683 to 0.206 .036 
 rs2296828 C/T vs C/C 0.0962 0.0257 to 0.167 .0075 
 rs4676428 G/G vs T/T −0.139 –0.261 to −0.0174 .025 
 rs2816608 C/T vs C/C −0.125 –0.197 to −0.0541 <.001 
 rs10512628 C/C vs T/T 0.0643 –0.0192 to 0.148 .13 
 rs4774471 T/A vs T/T 0.0700 –0.00400 to 0.144 .064 
 rs4774471 A/A vs T/T 0.145 0.0219 to 0.267 .021 
 rs17568628 T/C vs T/T 0.206 0.0662 to 0.346 .0039 
 rs7961894 T/T vs C/C 0.228 0.140 to 0.316 <.001 
VariableAllelesβ95% CIP
Females (n = 1975)     
 Age (per 5 y)  −0.0275 –0.0476 to −0.00732 .0076 
 Hypertension (%)  0.0849 –0.0122 to 0.182 .086 
 Diabetes (%)  0.206 0.0393 to 0.373 .015 
 Obesity (%)  −0.0684 –0.164 to 0.0268 .16 
 WBC (× 109/L)  0.0448 0.0240 to 0.0657 <.001 
 Platelets (× 109/L)  −0.00421 –0.00476 to −0.00366 <.001 
 Fibrinogen (mg/dL)  0.00121 0.000692 to 0.00173 <.001 
 Oral contraceptive (%)  0.271 0.109 to 0.433 .0010 
 Antithrombotics (%)  0.132 –0.00214 to 0.266 .054 
 Antihypertensive (%)  −0.114 –0.219 to −0.00860 .034 
 rs342293 C/G vs C/C 0.0978 0.0145 to 0.181 .021 
 rs342293 G/G vs C/C 0.236 0.132 to 0.340 <.001 
 rs10506328 C/A vs C/C 0.0565 –0.0160 to 0.129 .13 
 rs12485738 A/A vs G/G 0.169 0.0642 to 0.274 .0016 
 rs2138852 T/C vs T/T −0.0651 –0.153 to 0.0224 .14 
 rs2138852 C/C vs T/T −0.185 –0.287 to −0.0836 <.001 
 rs10076782 G/A vs G/G 0.0553 –0.0200 to 0.131 .15 
 rs11734132 G/C vs G/G −0.0607 –0.141 to 0.0195 .14 
 rs12969657 T/C vs T/T −0.128 –0.216 to −0.0396 .0045 
 rs12969657 C/C vs T/T −0.105 –0.210 to −0.00119 .047 
 rs13042885 C/T vs C/C −0.0860 –0.162 to −0.00948 .028 
 rs13042885 T/T vs C/C −0.150 –0.298 to −0.00252 .046 
 rs2950390 T/T vs C/C −0.0818 –0.193 to 0.0296 .15 
 rs4812048 C/T vs C/C −0.0897 –0.172 to −0.00777 .032 
 rs4812048 T/T vs C/C −0.190 –0.420 to 0.0395 .10 
 rs649729 A/T vs A/A 0.100 0.0240 to 0.177 .010 
 rs649729 T/T vs A/A 0.137 0.000939 to 0.273 .048 
 rs7317038 C/T vs C/C −0.0624 –0.136 to 0.0116 .098 
 rs12355784 C/A vs C/C −0.110 –0.197 to −0.0218 .014 
 rs12355784 A/A vs C/C −0.164 –0.267 to −0.0602 .0019 
 rs4951184 T/A vs T/T −0.0667 –0.145 to 0.0120 .096 
 rs4951184 A/A vs T/T −0.232 –0.342 to −0.121 <.001 
 rs7342306 G/A vs G/G 0.0623 –0.0193 to 0.144 .13 
 rs7342306 A/A vs G/G 0.147 0.0381 to 0.255 .0081 
 rs10512628 C/C vs T/T 0.0685 –0.0214 to 0.158 .14 
 rs17397129 A/G vs A/A 0.125 0.0397 to 0.211 .0041 
 rs17397129 G/G vs A/A 0.412 0.103 to 0.720 .0089 
 rs4774471 T/A vs T/T 0.0811 0.00424 to 0.158 .039 
 rs4774471 A/A vs T/T 0.237 0.115 to 0.360 <.001 
 rs6135137 G/A vs G/G 0.0902 0.0163 to 0.164 .017 
 rs17568628 T/C vs T/T 0.264 0.115 to 0.412 <.001 
 rs7961894 T/T vs C/C 0.222 0.134 to 0.311 <.001 
Males (n = 2084)     
 Age (per 5 y)  −0.0345 –0.0529 to −0.0160 <.001 
 Smoking (%)  0.103 0.00940 to 0.196 .031 
 Obesity (%)  0.0864 0.00388 to 0.169 .040 
 WBC (× 109/L)  0.0290 0.0165 to 0.0415 <.001 
 Platelets (× 109/L)  −0.00468 –0.00528 to −0.00408 <.001 
 CRP (mg/L)  −0.00743 –0.0154 to 0.000530 .067 
 Fibrinogen (mg/dL)  0.000881 0.000323 to 0.00144 .0020 
 Aspirin (%)  0.125 0.00380 to 0.247 .043 
 Antilipemic (%)  0.111 –0.000248 to 0.222 .051 
 Diuretics (%)  0.149 –0.00325 to 0.302 .055 
 rs342293 G/G vs C/C 0.172 0.0852 to 0.259 <.001 
 rs10506328 C/A vs C/C 0.138 0.0613 to 0.214 <.001 
 rs10506328 A/A vs C/C 0.171 0.0654 to 0.277 .0015 
 rs12485738 A/A vs G/G 0.116 0.0132 to 0.218 .027 
 rs2138852 T/C vs T/T −0.0741 –0.159 to 0.0103 .085 
 rs2138852 C/C vs T/T −0.180 –0.277 to −0.0823 <.001 
 rs2180748 G/T vs G/G −0.0960 –0.175 to −0.0173 .017 
 rs2180748 T/T vs G/G −0.110 –0.214 to −0.00552 .039 
 rs11734132 G/C vs G/G −0.0665 –0.145 to 0.0116 .095 
 rs11734132 C/C vs G/G −0.188 –0.416 to 0.0405 .11 
 rs13042885 C/T vs C/C −0.0758 –0.150 to −0.00184 .045 
 rs13042885 T/T vs C/C −0.215 –0.352 to −0.0779 .0021 
 rs2950390 T/T vs C/C −0.103 –0.214 to 0.00861 .071 
 rs12355784 A/A vs C/C −0.0651 –0.146 to 0.0153 .11 
 rs4951184 T/A vs T/T −0.0603 –0.136 to 0.0159 .12 
 rs4951184 A/A vs T/T −0.213 –0.322 to −0.104 <.001 
 rs7342306 G/A vs G/G 0.136 0.0560 to 0.215 <.001 
 rs7342306 A/A vs G/G 0.106 0.00683 to 0.206 .036 
 rs2296828 C/T vs C/C 0.0962 0.0257 to 0.167 .0075 
 rs4676428 G/G vs T/T −0.139 –0.261 to −0.0174 .025 
 rs2816608 C/T vs C/C −0.125 –0.197 to −0.0541 <.001 
 rs10512628 C/C vs T/T 0.0643 –0.0192 to 0.148 .13 
 rs4774471 T/A vs T/T 0.0700 –0.00400 to 0.144 .064 
 rs4774471 A/A vs T/T 0.145 0.0219 to 0.267 .021 
 rs17568628 T/C vs T/T 0.206 0.0662 to 0.346 .0039 
 rs7961894 T/T vs C/C 0.228 0.140 to 0.316 <.001 

Multivariable linear regression model for MPV in females and males with variables selected by Akaike information criteria. Females: R2, 0.204; males: R2, 0.186. P values <.05 are shown in bold.

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