Response evaluation 0.24 mg/kg/d cohort by treatment indication (N = 46)
. | N . | Responses . | Treatment failure . | Response rate, % . | ||||
---|---|---|---|---|---|---|---|---|
CR . | CRi . | Persistent leukemia . | Death during aplasia . | Unknown . | CR + CRi . | CR only . | ||
First relapse, first salvage, total | 32 | 15 | 3 | 12 | 1 | 0 | 56 | 47 |
CR1 < 6 mo | 11 | 2 | 1 | 7 | 0 | 1 | 27 | 18 |
First salvage, CR1 6-12 mo | 11 | 5 | 2 | 4 | 0 | 0 | 64 | 45 |
First salvage, CR1 > 12 mo | 10 | 8 | 0 | 1 | 1 | 0 | 80 | 80 |
Primary refractory, total | 10 | 2 | 0 | 6 | 2 | 0 | 20 | 20 |
1 induction | 8 | 2 | 0 | 5 | 1 | 0 | 25 | 25 |
≥ 2 inductions | 2 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
≥ Second relapse /salvage | 4 | 1 | 0 | 3 | 0 | 0 | 25 | 25 |
Total | 46 | 18 | 3 | 21 | 3 | 1 | 46 | 39 |
. | N . | Responses . | Treatment failure . | Response rate, % . | ||||
---|---|---|---|---|---|---|---|---|
CR . | CRi . | Persistent leukemia . | Death during aplasia . | Unknown . | CR + CRi . | CR only . | ||
First relapse, first salvage, total | 32 | 15 | 3 | 12 | 1 | 0 | 56 | 47 |
CR1 < 6 mo | 11 | 2 | 1 | 7 | 0 | 1 | 27 | 18 |
First salvage, CR1 6-12 mo | 11 | 5 | 2 | 4 | 0 | 0 | 64 | 45 |
First salvage, CR1 > 12 mo | 10 | 8 | 0 | 1 | 1 | 0 | 80 | 80 |
Primary refractory, total | 10 | 2 | 0 | 6 | 2 | 0 | 20 | 20 |
1 induction | 8 | 2 | 0 | 5 | 1 | 0 | 25 | 25 |
≥ 2 inductions | 2 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
≥ Second relapse /salvage | 4 | 1 | 0 | 3 | 0 | 0 | 25 | 25 |
Total | 46 | 18 | 3 | 21 | 3 | 1 | 46 | 39 |
CRi indicates complete remission with incomplete blood count recovery.