Table 3

Risk factors for OS and PFS

VariablesOS
PFS
Univariate analysis
Multivariate analysis
Univariate analysis
Multivariate analysis
HR95% CIPHR95% CIPHR95% CIPHR95% CIP
Age > 60 y 1.53 0.98-2.38 .060 1.65 1.03-2.64 .039 1.31 0.89-1.96 .172    
Sex, male 1.58 1.04-2.40 .031    1.53 1.06-2.20 .023    
PS > 1 1.82 1.24-2.66 .002    1.71 1.21-2.41 .002    
Stage > II 1.40 0.73-2.69 .318    1.35 0.76-2.40 .301    
Positive B-symptoms 1.26 0.85-1.86 .258    1.26 0.89-1.79 .197    
WBC level > 1.0 × 104/mm3 1.51 1.01-2.26 .044 1.83 1.18-2.83 .006 1.42 0.98-2.05 .064    
Anemia* 1.91 1.27-2.86 .002 1.88 1.57-3.86 .004 1.67 1.17-2.39 .005 1.70 1.18-2.46 .005 
Platelet count < 15 × 104/mm3 1.47 0.98-2.21 .062 1.70 1.10-2.63 .017 1.20 0.83-1.72 .337    
IgG level ≤1700 mg/dL 1.17 0.77-1.77 .458    1.11 0.77-1.61 .578    
IgA level > 400 mg/dL 1.66 1.08-2.53 .020 1.73 1.12-2.67 .013 1.92 1.31-2.80 .001 1.95 1.32-2.88 .001 
IgM level > 250 mg/dL 0.93 0.60-1.43 .743    0.99 0.67-1.45 .942    
LDH level > ULN 1.52 0.96-2.41 .076    0.99 0.68-1.46 .974    
Serum albumin level < 3.5 g/dL 1.80 1.22-2.65 .003    1.36 0.96-1.91 .084    
Serum total protein level < 6.5 g/dL 1.71 1.12-2.60 .013    1.34 0.90-1.98 .147    
β2-MG ≥ 4.0 mg/dL 1.78 0.94-3.36 .077    1.20 0.68-2.12 .534    
Extranodal involvement > 1 2.29 1.49-3.53 < .001 2.46 1.57-3.86 < .001 1.88 1.26-2.80 .002    
BM involvement 1.18 0.78-1.78 .425    1.14 0.78-1.65 .502    
Mediastinal lymphadenopathy 1.57 1.07-2.31 .022    1.50 1.07-2.12 .020 1.75 1.22-2.52 .002 
CRP ≥ 2.0 mg/dL 1.19 0.81-1.78 .370    1.03 0.73-1.46 .864    
sIL-2R > 4000 U/mL 2.00 1.29-3.12 .002    1.49 1.02-2.18 .041    
IPI score > 2 2.16 1.37-3.40 .001    1.46 1.00-2.12 .051    
PIT score > 2 2.03 1.29-3.19 .002    1.21 0.82-1.81 .330    
VariablesOS
PFS
Univariate analysis
Multivariate analysis
Univariate analysis
Multivariate analysis
HR95% CIPHR95% CIPHR95% CIPHR95% CIP
Age > 60 y 1.53 0.98-2.38 .060 1.65 1.03-2.64 .039 1.31 0.89-1.96 .172    
Sex, male 1.58 1.04-2.40 .031    1.53 1.06-2.20 .023    
PS > 1 1.82 1.24-2.66 .002    1.71 1.21-2.41 .002    
Stage > II 1.40 0.73-2.69 .318    1.35 0.76-2.40 .301    
Positive B-symptoms 1.26 0.85-1.86 .258    1.26 0.89-1.79 .197    
WBC level > 1.0 × 104/mm3 1.51 1.01-2.26 .044 1.83 1.18-2.83 .006 1.42 0.98-2.05 .064    
Anemia* 1.91 1.27-2.86 .002 1.88 1.57-3.86 .004 1.67 1.17-2.39 .005 1.70 1.18-2.46 .005 
Platelet count < 15 × 104/mm3 1.47 0.98-2.21 .062 1.70 1.10-2.63 .017 1.20 0.83-1.72 .337    
IgG level ≤1700 mg/dL 1.17 0.77-1.77 .458    1.11 0.77-1.61 .578    
IgA level > 400 mg/dL 1.66 1.08-2.53 .020 1.73 1.12-2.67 .013 1.92 1.31-2.80 .001 1.95 1.32-2.88 .001 
IgM level > 250 mg/dL 0.93 0.60-1.43 .743    0.99 0.67-1.45 .942    
LDH level > ULN 1.52 0.96-2.41 .076    0.99 0.68-1.46 .974    
Serum albumin level < 3.5 g/dL 1.80 1.22-2.65 .003    1.36 0.96-1.91 .084    
Serum total protein level < 6.5 g/dL 1.71 1.12-2.60 .013    1.34 0.90-1.98 .147    
β2-MG ≥ 4.0 mg/dL 1.78 0.94-3.36 .077    1.20 0.68-2.12 .534    
Extranodal involvement > 1 2.29 1.49-3.53 < .001 2.46 1.57-3.86 < .001 1.88 1.26-2.80 .002    
BM involvement 1.18 0.78-1.78 .425    1.14 0.78-1.65 .502    
Mediastinal lymphadenopathy 1.57 1.07-2.31 .022    1.50 1.07-2.12 .020 1.75 1.22-2.52 .002 
CRP ≥ 2.0 mg/dL 1.19 0.81-1.78 .370    1.03 0.73-1.46 .864    
sIL-2R > 4000 U/mL 2.00 1.29-3.12 .002    1.49 1.02-2.18 .041    
IPI score > 2 2.16 1.37-3.40 .001    1.46 1.00-2.12 .051    
PIT score > 2 2.03 1.29-3.19 .002    1.21 0.82-1.81 .330    

LDH indicates lactate dehydrogenase; β2-MG, β2 microglobulin; CRP, C-reactive protein; and sIL-2R, soluble IL-2 receptor.

*

The presence of anemia was defined as the value of hemoglobin < 13.0 g/dL for men and 11.0 g/dL for women.

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