The role of adaptive immune response in restricting virus replication and affecting disease progression has been investigated by in vivo studies of CD8, B, or CD8 and B-cell depletion
| . | Viral load . | AIDS progression . | ||
|---|---|---|---|---|
| Natural hosts (AGM/SM) . | Non-natural hosts (RM/PTM) . | Natural hosts (AGM/SM) . | Non-natural hosts (RM/PTM) . | |
| CD8 cell depletion | Brief increase | ∼ 1.5 log increase | No effect | Faster |
| B-cell depletion | No effect | Unclear: | No effect | Unclear: |
| Increase76 | Faster76 | |||
| No effect78 | No effect78 | |||
| CD8 and B-cell depletion | Brief increase | 1 log increase peak; 4 log increase set-point | No effect | Faster |
| . | Viral load . | AIDS progression . | ||
|---|---|---|---|---|
| Natural hosts (AGM/SM) . | Non-natural hosts (RM/PTM) . | Natural hosts (AGM/SM) . | Non-natural hosts (RM/PTM) . | |
| CD8 cell depletion | Brief increase | ∼ 1.5 log increase | No effect | Faster |
| B-cell depletion | No effect | Unclear: | No effect | Unclear: |
| Increase76 | Faster76 | |||
| No effect78 | No effect78 | |||
| CD8 and B-cell depletion | Brief increase | 1 log increase peak; 4 log increase set-point | No effect | Faster |
Comparison of the effects induced by these depletions in natural and non-natural hosts for SIV.
AGM/SM indicates African green monkey/sooty mangabey; and RM/PTM, rhesus macaque/pigtail macaque.