Genes up-regulated by dexamethasone (Dex), lenalidomide (Len), and the combination of the two drugs with published effects on erythropoiesis
| Name . | Description . | Up-regulated . | Role in erythropoiesis . |
|---|---|---|---|
| IL-18R1 | IL-18 receptor 1 | Dex | Expressed on normal erythroid cell lines42 |
| SOCS-1 | Suppressor of cytokine signaling 1 | Dex | Mice lacking SOCS-1 have a subnormal hematocrit and an accumulation of immature red blood cells17 |
| IL-1R2 | IL-1 receptor, type II | Len | Nonsignaling receptor; expressed on hematopoietic stem cells43 |
| FLT3 | fms-related tyrosine kinase 3 | Len | Forced expression of FLT3-ITD in CD34+ cells confers proliferative advantage with increased erythroid differentiation18 |
| CD163 | CD163 molecule | Len | Macrophage adhesion molecule involved in erythroblastic islands44 |
| RHCE | Rh blood group, CcEe antigens | Dex + Len | Rh antigens appear early during erythropoietic differentiation45 |
| JAK2 | Janus kinase 2 (a protein tyrosine kinase) | Dex + Len | Essential role in erythropoiesis, including response to erythropoietin46 |
| AQP3 | Aquaporin 3 (GIL blood group) | Dex + Len | Water and glycerol channel present on human erythrocytes; also encodes GIL blood group system47 |
| Name . | Description . | Up-regulated . | Role in erythropoiesis . |
|---|---|---|---|
| IL-18R1 | IL-18 receptor 1 | Dex | Expressed on normal erythroid cell lines42 |
| SOCS-1 | Suppressor of cytokine signaling 1 | Dex | Mice lacking SOCS-1 have a subnormal hematocrit and an accumulation of immature red blood cells17 |
| IL-1R2 | IL-1 receptor, type II | Len | Nonsignaling receptor; expressed on hematopoietic stem cells43 |
| FLT3 | fms-related tyrosine kinase 3 | Len | Forced expression of FLT3-ITD in CD34+ cells confers proliferative advantage with increased erythroid differentiation18 |
| CD163 | CD163 molecule | Len | Macrophage adhesion molecule involved in erythroblastic islands44 |
| RHCE | Rh blood group, CcEe antigens | Dex + Len | Rh antigens appear early during erythropoietic differentiation45 |
| JAK2 | Janus kinase 2 (a protein tyrosine kinase) | Dex + Len | Essential role in erythropoiesis, including response to erythropoietin46 |
| AQP3 | Aquaporin 3 (GIL blood group) | Dex + Len | Water and glycerol channel present on human erythrocytes; also encodes GIL blood group system47 |