Table 3

Incidence of infections (all grades) with CFAR therapy by NCI-WG response and course number

InfectionNo. of coursesTotal no. of infectionsNo. of major infectionsRisk per course
Response     
    CR 191 36 19 0.18 
    nPR 0.11 
    PR 48 0.14 
    NR 12  0.17 
Course no.     
    1-3 175 24 0.14 
    4-6 85 22 18 0.23 
InfectionNo. of coursesTotal no. of infectionsNo. of major infectionsRisk per course
Response     
    CR 191 36 19 0.18 
    nPR 0.11 
    PR 48 0.14 
    NR 12  0.17 
Course no.     
    1-3 175 24 0.14 
    4-6 85 22 18 0.23 

Risk per course refers to the total number of infections/number of courses. Major infections refers to pneumonia, sepsis, fever of unknown origin requiring hospitalization.

CFAR indicates alemtuzumab added to FCR; NCI-WG, National Cancer Institute–Working Group; CR, complete remission; nPR, nodular partial remission; PR, partial remission; and NR, no response.

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