IFN-γ–dependent normochromic and normocytic anemia in CD70TG mice
| . | WT . | CD70TG . | IFN-γ−/− . | CD70TG* IFN-γ−/− . |
|---|---|---|---|---|
| RBCs × 1012/L | 9.13 (0.84) | 6.58 (1.08)* | 8.59 (0.41) | 8.30 (0.57) |
| Hemoglobin, mM | 9.30 (0.75) | 7.18 (1.01)* | 8.89 (0.32) | 8.56 (0.59) |
| Hematocrit, L/L | 0.49 (0.04) | 0.39 (0.07)* | 0.49 (0.03) | 0.47 (0.02) |
| RDW, % | 18.86 (1.57) | 18.04 (1.69) | 19.31 (2.24) | 23.32 (3.61) |
| MCH, fmol | 1.03 (0.02) | 1.10 (0.03)* | 1.04 (0.02) | 1.04 (0.02) |
| MCV, fL | 54.17 (3.66) | 53.37 (6.22) | 51.27 (3.42) | 51.27 (5.35) |
| MCHC, mM | 19.17 (1.54) | 20.26 (1.63) | 19.30 (1.09) | 19.85 (1.60) |
| . | WT . | CD70TG . | IFN-γ−/− . | CD70TG* IFN-γ−/− . |
|---|---|---|---|---|
| RBCs × 1012/L | 9.13 (0.84) | 6.58 (1.08)* | 8.59 (0.41) | 8.30 (0.57) |
| Hemoglobin, mM | 9.30 (0.75) | 7.18 (1.01)* | 8.89 (0.32) | 8.56 (0.59) |
| Hematocrit, L/L | 0.49 (0.04) | 0.39 (0.07)* | 0.49 (0.03) | 0.47 (0.02) |
| RDW, % | 18.86 (1.57) | 18.04 (1.69) | 19.31 (2.24) | 23.32 (3.61) |
| MCH, fmol | 1.03 (0.02) | 1.10 (0.03)* | 1.04 (0.02) | 1.04 (0.02) |
| MCV, fL | 54.17 (3.66) | 53.37 (6.22) | 51.27 (3.42) | 51.27 (5.35) |
| MCHC, mM | 19.17 (1.54) | 20.26 (1.63) | 19.30 (1.09) | 19.85 (1.60) |
Hemocytometric analysis of 10- to 16-week-old WT, CD70TG, IFN-γ−/−, and CD70TG*IFN-γ−/− mice. Values indicate the mean (SD) from 10-18 mice.
RBC indicates red blood cell; RDW, red cell distribution width; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; and MCHC; mean corpuscular hemoglobin concentration.
Significant difference (P < .05) between CD70TG mice and all other groups (1-way ANOVA with Bonferroni correction).