Table 3 Comparison of thrombosis outcome... | American Society of Hematology

Table 3

Comparison of thrombosis outcome in women with factor V Leiden or prothrombin G20210A, or a combination of these defects (including homozygosity)

	Defects				No defects
	COC	LNG-IUD	Copper IUD (380 mm²)	Condom*	COC	LNG-IUD	Copper IUD (380 mm²)	Condom*
Incidence of first VTE per 100 pregnancy-years	0.55†	0.25‡	0.25‡	0.25‡	0.19	0.09	0.09	0.09
Cases of VTE per 100 000 pregnancy-years	550	250	250	250	190	90	90	90
Contraceptive failure rate, per 100 women-years§	0.2	0.7	1.4	12	0.2	0.7	1.4	12
Unintended pregnancies per 100 000 pregnancy-years	200	700	1400	12 000	200	700	1400	12 000
Incidence of VTE per 100 pregnancy-years¶	2.8	2.8	2.8	2.8	0.7	0.7	0.7	0.7
Additional cases of VTE	6	20	40	336	2	5	10	84
Total number of VTE	556	270	290	586	192	95	100	174

	Defects				No defects
	COC	LNG-IUD	Copper IUD (380 mm²)	Condom*	COC	LNG-IUD	Copper IUD (380 mm²)	Condom*
Incidence of first VTE per 100 pregnancy-years	0.55†	0.25‡	0.25‡	0.25‡	0.19	0.09	0.09	0.09
Cases of VTE per 100 000 pregnancy-years	550	250	250	250	190	90	90	90
Contraceptive failure rate, per 100 women-years§	0.2	0.7	1.4	12	0.2	0.7	1.4	12
Unintended pregnancies per 100 000 pregnancy-years	200	700	1400	12 000	200	700	1400	12 000
Incidence of VTE per 100 pregnancy-years¶	2.8	2.8	2.8	2.8	0.7	0.7	0.7	0.7
Additional cases of VTE	6	20	40	336	2	5	10	84
Total number of VTE	556	270	290	586	192	95	100	174

According to the method described by Koster et al.³⁹

LNG-IUD indicates levonorgestrel intrauterine device; HR, hazard ratio; and VTE, venous thromboembolism.

US data.

(6 + 2) events during (1218 + 232) pill-years (see Table 2).

Based on an adjusted HR of 2.2 for COC use when compared to no COC use.

Pearl Index for correct use (method failure).

(10 + 7) events during (507 + 92) pregnancy-years (see Table 2).