Probability of rejecting at either 50 or 100 patients, and average arm size for a worthless treatment (no benefit), and power, and average arm size for a worthwhile treatment (15% improvement in CR) based on a baseline CR rate of 15%
| Critical improvement in CR rate at 100 patients (Δ)2, % . | Critical improvement in CR rate after 50 patients (Δ1) . | ||||
|---|---|---|---|---|---|
| 0%, % (no.) . | 2.5%, % (no.) . | 5%, % (no.) . | 7.5%, % (no.) . | 10%, % (no.) . | |
| 2.5 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | 72 (106) | — | — | — | — |
| Probability of accepting worthwhile treatment, power (mean size per arm) | 93 (195) | — | — | — | — |
| 5 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | 82 (96) | 85 (82)† | — | — | — |
| Probability of accepting worthwhile treatment, power (mean size per arm) | 92 (194) | 89 (188)† | — | — | — |
| 7.5 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | 93 (85) | 93 (74)† | 94 (68)† | — | — |
| Probability of accepting worthwhile treatment, power (mean size per arm) | 88 (188) | 85 (184)† | 83 (179)† | — | — |
| 10 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | 97 (81) | 97 (70) | 97 (65) | 97 (61) | — |
| Probability of accepting worthwhile treatment, power (mean size per arm) | 81 (181) | 79 (177) | 78 (173) | 75 (168) | — |
| 15 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | > 99.5 (78) | > 99.5 (67) | > 99.5 (62) | > 99.5 (59) | > 99.5 (56) |
| Probability of accepting worthwhile treatment, power (mean size per arm) | |||||
| 72 (145) | 71 (143) | 70 (140) | 68 (137) | 64 (133) | |
| Critical improvement in CR rate at 100 patients (Δ)2, % . | Critical improvement in CR rate after 50 patients (Δ1) . | ||||
|---|---|---|---|---|---|
| 0%, % (no.) . | 2.5%, % (no.) . | 5%, % (no.) . | 7.5%, % (no.) . | 10%, % (no.) . | |
| 2.5 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | 72 (106) | — | — | — | — |
| Probability of accepting worthwhile treatment, power (mean size per arm) | 93 (195) | — | — | — | — |
| 5 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | 82 (96) | 85 (82)† | — | — | — |
| Probability of accepting worthwhile treatment, power (mean size per arm) | 92 (194) | 89 (188)† | — | — | — |
| 7.5 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | 93 (85) | 93 (74)† | 94 (68)† | — | — |
| Probability of accepting worthwhile treatment, power (mean size per arm) | 88 (188) | 85 (184)† | 83 (179)† | — | — |
| 10 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | 97 (81) | 97 (70) | 97 (65) | 97 (61) | — |
| Probability of accepting worthwhile treatment, power (mean size per arm) | 81 (181) | 79 (177) | 78 (173) | 75 (168) | — |
| 15 | |||||
| Probability of rejecting treatment early if worthless* (mean size per arm) | > 99.5 (78) | > 99.5 (67) | > 99.5 (62) | > 99.5 (59) | > 99.5 (56) |
| Probability of accepting worthwhile treatment, power (mean size per arm) | |||||
| 72 (145) | 71 (143) | 70 (140) | 68 (137) | 64 (133) | |