Risk factors for chronic GVHD among 1-year survivors
| . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Acute GVHD prophylaxis | ||||
| Single agent | 1.0 | |||
| Multiple agents | 1.47 (0.8-2.7) | .22 | ||
| Buffy coat | ||||
| No | 1.0 | 1.0 | ||
| Yes | 2.13 (1.1-4.2) | .04 | 2.79 (1.3-5.8) | .01 |
| Regimen | ||||
| Cyclophosphamide | 1.0 | |||
| TBI, low (2-6 Gy) | 1.18 (0.4-3.4) | |||
| TBI, high (10-12 Gy) | 3.68 (1.7-8.1) | .02 | ||
| Donor | ||||
| Matched related | 1.0 | 1.0 | ||
| Mismatched related | 5.36 (2.1-14) | .01 | 6.98 (2.6-19) | .004 |
| Unrelated | 1.53 (0.6-3.7) | 1.98 (0.8-4.9) | ||
| . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Acute GVHD prophylaxis | ||||
| Single agent | 1.0 | |||
| Multiple agents | 1.47 (0.8-2.7) | .22 | ||
| Buffy coat | ||||
| No | 1.0 | 1.0 | ||
| Yes | 2.13 (1.1-4.2) | .04 | 2.79 (1.3-5.8) | .01 |
| Regimen | ||||
| Cyclophosphamide | 1.0 | |||
| TBI, low (2-6 Gy) | 1.18 (0.4-3.4) | |||
| TBI, high (10-12 Gy) | 3.68 (1.7-8.1) | .02 | ||
| Donor | ||||
| Matched related | 1.0 | 1.0 | ||
| Mismatched related | 5.36 (2.1-14) | .01 | 6.98 (2.6-19) | .004 |
| Unrelated | 1.53 (0.6-3.7) | 1.98 (0.8-4.9) | ||
CI indicates confidence interval; HR, hazard ratio; and TBI, total body irradiation.