Table 1 Differentially expressed genes... | American Society of Hematology

Table 1

Differentially expressed genes in Scl^Δ/Δ MkPs

Gene symbol	Fold change*	Accession no.
Adhesion/migration
Col18a1†	7.77	NM_009929.2
Megf10	3.63	NM_001001979
Emilin2	3.29	NM_145158
Cd72	2.73	NM_007654.1
Serpine2†	2.22	AK045954
Map17	2.12	NM_026018.1
Cd63†	1.77	NM_007653.1
Emid1	1.75	NM_080595.1
Cxcr4†	1.75	NM_009911.2
Ltbp1	1.61	NM_019919.2
Mfge8	1.45	NM_008594
Tens1	0.66	XM_109868
Elmo1	0.6	NM_080288.1
Esam1	0.55	NM_027102.1
Selp†	0.4	NM_011347.1
Cell cycle/apoptosis
Cdkn1a†	3.26	NM_007669.2
Tnfrsf18	1.97	NM_009400.1
Rassf2	1.64	NM_175445.3
Bin1	1.62	AK041729.1
Bcl2†	1.59	NM_177410.1
Ndg2	1.5	NM_175329.3
Tmbim4	1.5	NM_026617.1
Cryab	1.37	NM_009964.1
Nalp6	0.65	NM_133946.1
Catnal1	0.47	NM_018761.2
Transcription
Mta3	2.2	NM_054082.1
Carhsp1	2.04	NM_025821.2
Lyl1	1.77	NM_008535.1
Rcor1	1.66	NM_054048.1
Gata2	1.57	NM_008090.3
Hes6	1.52	NM_019479.2
Foxp1	1.48	NM_053202.1
Mta2	1.48	NM_011842.2
Chd7	0.71	XM_149413.3
Fhl1	0.69	NM_010211.1
Ccndbp1	0.68	NM_010761.1
Hoxb5	0.67	NM_008268.1
Mysm1	0.65	NM_177239.1
Fos	0.61	NM_010234.2
Ctdspl2	0.59	XM_283758.1
Tle1	0.52	NM_011599.2
Ear10	0.35	NM_053112.1
Ear2	0.34	NM_007895
Tal1	0.2	NM_011527.1
Immune response
Igh-6	6.66	XM_354710.1
Cst7	2.57	NM_009977.1
Clecsf8	2.44	NM_010819.1
Cd59a	0.54	NM_007652.2
Signal transduction
Fcer1g†	6	NM_010185.2
P2ry14	2.84	NM_133200.2
Wbscr5	2.51	NM_022964.2
Ppp1r1c	2.13	NM_033264.1
Cd69	1.98	XM_132882.1
Mrvi1†	1.97	NM_194464.1
Itgb3bp	1.88	NM_026348.2
Il15	1.87	NM_008357.1
Centd1†	1.81	XM_132099.5
Rpel1	1.79	NM_198419.2
Dok4	1.75	NM_053246.1
Tas1r1	1.7	NM_031867.1
Fgf3	1.69	NM_008007.1
Irak3	1.69	NM_028679.2
Dusp4	1.69	NM_176933
Cysltr1	1.63	NM_021476.2
Diras2	1.68	NM_001024474
Lat†	1.54	NM_010689.2
Plekhg5	1.5	NM_001004156
Agtrap	1.48	NM_009642.3
Rab27a	1.48	NM_023635.2
Ly6e	1.46	NM_008529
Il18r1	1.45	NM_008365.1
Cd244	1.36	NM_018729.1
Dusp1	0.69	NM_013642.1
Grb10	0.67	AK012646
Gucy1a3	0.62	NM_021896.3
Rab11a	0.62	NM_017382
Fcgr2b	0.6	NM_010187.1
Pdgfb	0.57	NM_011057.2
Drctnnb1a	0.56	NM_053090
Il6ra	0.48	AK020663
Gnaz†	0.45	NM_010311.2
Pde10a	0.37	NM_011866.1
Transport
Alox5	5.53	XM_132832.3
Tnni1	2.04	NM_021467
Emid1	1.98	NM_080595.1
Tnni3	1.97	NM_009406.2
Slc6a13	1.85	NM_144512.1
Hbb-b1	1.79	AK005442
Tpcn1	1.73	NM_145853.2
Ddx25	1.72	NM_013932.2
Spns3	1.71	XM_126365.3
Igf2r	1.56	NM_010515.1
Slc5a9	1.56	NM_145551.2
Slc14a1	0.68	NM_028122.2
Abcc5	0.67	NM_176839.1
Car2	0.53	NM_009801.3
Hebp1	0.51	NM_013546.1
Cytoskeleton organization
Myo18b†	4.84	XM_144513.3
Tpm2	2.4	NM_009416.2
Cap1	2.07	NM_007598.2
Myo6†	1.65	NM_008662.1
Ehd2	1.53	AK029240
Homer2	0.46	XM_133550.4
Ubiquitination
Usp20	1.56	NM_028846.1
Usp40	0.54	XM_129956.2
Metabolism
Chst1	4.71	NM_023850.1
Alox5	3.95	XM_132832
Abat	2.31	NM_172961.2
Padi2	2.2	NM_008812.1
Hmgcs2	1.88	NM_008256.2
Acas2l	1.65	NM_080575.1
Ltc4s	1.65	NM_008521.1
Rsdr1-pending	1.64	AK087137
Dhrs3	1.45	NM_011303.2
Gchfr	0.71	NM_177157.2
Chsy3	0.65	NM_178636
Oxr1	0.63	AK040881
Hyi	0.6	XM_489058
Mtap	0.6	NM_024433.1
Serpinb1a	0.56	NM_025429.1
Gucy1a3	0.47	NM_021896.3
Sdh1	0.45	NM_146126.1
Serpina3g	0.4	XM_354694.1
Serpina3b	0.38	NM_173024.1
Unidentified
9830134C10Rik	3.43	AK036563
2310047A01Rik	2.56	XM_484355
LOC381142	2.09	XM_355058.1
6430559E15Rik	1.99	XM_131537.4
C130080K17Rik	1.71	AK081831
LOC382231	1.69	XM_356343.1
1110012N22Rik	1.68	XM_126634.3
BC023181	1.6	XM_194180.3
4930427A07Rik	1.51	NM_134041.1
BC057022	1.5	NM_001004180.1
0610037L13Rik	0.72	NM_028754.1
5730446C15Rik	0.69	NM_146096
B930074N03Rik	0.68	AK047478
BC023823	0.68	NM_153566.1
C530050O22Rik	0.68	NM_172871.1
AY078069	0.66	NM_172142.1
D8Ertd594e	0.66	NM_133791.3
2900008M13Rik	0.63	XM_110121
2010300G19Rik	0.61	NM_028097.2
BC049975	0.59	XM_138237.2
9030611O19Rik	0.57	NM_027828.2

Gene symbol	Fold change*	Accession no.
Adhesion/migration
Col18a1†	7.77	NM_009929.2
Megf10	3.63	NM_001001979
Emilin2	3.29	NM_145158
Cd72	2.73	NM_007654.1
Serpine2†	2.22	AK045954
Map17	2.12	NM_026018.1
Cd63†	1.77	NM_007653.1
Emid1	1.75	NM_080595.1
Cxcr4†	1.75	NM_009911.2
Ltbp1	1.61	NM_019919.2
Mfge8	1.45	NM_008594
Tens1	0.66	XM_109868
Elmo1	0.6	NM_080288.1
Esam1	0.55	NM_027102.1
Selp†	0.4	NM_011347.1
Cell cycle/apoptosis
Cdkn1a†	3.26	NM_007669.2
Tnfrsf18	1.97	NM_009400.1
Rassf2	1.64	NM_175445.3
Bin1	1.62	AK041729.1
Bcl2†	1.59	NM_177410.1
Ndg2	1.5	NM_175329.3
Tmbim4	1.5	NM_026617.1
Cryab	1.37	NM_009964.1
Nalp6	0.65	NM_133946.1
Catnal1	0.47	NM_018761.2
Transcription
Mta3	2.2	NM_054082.1
Carhsp1	2.04	NM_025821.2
Lyl1	1.77	NM_008535.1
Rcor1	1.66	NM_054048.1
Gata2	1.57	NM_008090.3
Hes6	1.52	NM_019479.2
Foxp1	1.48	NM_053202.1
Mta2	1.48	NM_011842.2
Chd7	0.71	XM_149413.3
Fhl1	0.69	NM_010211.1
Ccndbp1	0.68	NM_010761.1
Hoxb5	0.67	NM_008268.1
Mysm1	0.65	NM_177239.1
Fos	0.61	NM_010234.2
Ctdspl2	0.59	XM_283758.1
Tle1	0.52	NM_011599.2
Ear10	0.35	NM_053112.1
Ear2	0.34	NM_007895
Tal1	0.2	NM_011527.1
Immune response
Igh-6	6.66	XM_354710.1
Cst7	2.57	NM_009977.1
Clecsf8	2.44	NM_010819.1
Cd59a	0.54	NM_007652.2
Signal transduction
Fcer1g†	6	NM_010185.2
P2ry14	2.84	NM_133200.2
Wbscr5	2.51	NM_022964.2
Ppp1r1c	2.13	NM_033264.1
Cd69	1.98	XM_132882.1
Mrvi1†	1.97	NM_194464.1
Itgb3bp	1.88	NM_026348.2
Il15	1.87	NM_008357.1
Centd1†	1.81	XM_132099.5
Rpel1	1.79	NM_198419.2
Dok4	1.75	NM_053246.1
Tas1r1	1.7	NM_031867.1
Fgf3	1.69	NM_008007.1
Irak3	1.69	NM_028679.2
Dusp4	1.69	NM_176933
Cysltr1	1.63	NM_021476.2
Diras2	1.68	NM_001024474
Lat†	1.54	NM_010689.2
Plekhg5	1.5	NM_001004156
Agtrap	1.48	NM_009642.3
Rab27a	1.48	NM_023635.2
Ly6e	1.46	NM_008529
Il18r1	1.45	NM_008365.1
Cd244	1.36	NM_018729.1
Dusp1	0.69	NM_013642.1
Grb10	0.67	AK012646
Gucy1a3	0.62	NM_021896.3
Rab11a	0.62	NM_017382
Fcgr2b	0.6	NM_010187.1
Pdgfb	0.57	NM_011057.2
Drctnnb1a	0.56	NM_053090
Il6ra	0.48	AK020663
Gnaz†	0.45	NM_010311.2
Pde10a	0.37	NM_011866.1
Transport
Alox5	5.53	XM_132832.3
Tnni1	2.04	NM_021467
Emid1	1.98	NM_080595.1
Tnni3	1.97	NM_009406.2
Slc6a13	1.85	NM_144512.1
Hbb-b1	1.79	AK005442
Tpcn1	1.73	NM_145853.2
Ddx25	1.72	NM_013932.2
Spns3	1.71	XM_126365.3
Igf2r	1.56	NM_010515.1
Slc5a9	1.56	NM_145551.2
Slc14a1	0.68	NM_028122.2
Abcc5	0.67	NM_176839.1
Car2	0.53	NM_009801.3
Hebp1	0.51	NM_013546.1
Cytoskeleton organization
Myo18b†	4.84	XM_144513.3
Tpm2	2.4	NM_009416.2
Cap1	2.07	NM_007598.2
Myo6†	1.65	NM_008662.1
Ehd2	1.53	AK029240
Homer2	0.46	XM_133550.4
Ubiquitination
Usp20	1.56	NM_028846.1
Usp40	0.54	XM_129956.2
Metabolism
Chst1	4.71	NM_023850.1
Alox5	3.95	XM_132832
Abat	2.31	NM_172961.2
Padi2	2.2	NM_008812.1
Hmgcs2	1.88	NM_008256.2
Acas2l	1.65	NM_080575.1
Ltc4s	1.65	NM_008521.1
Rsdr1-pending	1.64	AK087137
Dhrs3	1.45	NM_011303.2
Gchfr	0.71	NM_177157.2
Chsy3	0.65	NM_178636
Oxr1	0.63	AK040881
Hyi	0.6	XM_489058
Mtap	0.6	NM_024433.1
Serpinb1a	0.56	NM_025429.1
Gucy1a3	0.47	NM_021896.3
Sdh1	0.45	NM_146126.1
Serpina3g	0.4	XM_354694.1
Serpina3b	0.38	NM_173024.1
Unidentified
9830134C10Rik	3.43	AK036563
2310047A01Rik	2.56	XM_484355
LOC381142	2.09	XM_355058.1
6430559E15Rik	1.99	XM_131537.4
C130080K17Rik	1.71	AK081831
LOC382231	1.69	XM_356343.1
1110012N22Rik	1.68	XM_126634.3
BC023181	1.6	XM_194180.3
4930427A07Rik	1.51	NM_134041.1
BC057022	1.5	NM_001004180.1
0610037L13Rik	0.72	NM_028754.1
5730446C15Rik	0.69	NM_146096
B930074N03Rik	0.68	AK047478
BC023823	0.68	NM_153566.1
C530050O22Rik	0.68	NM_172871.1
AY078069	0.66	NM_172142.1
D8Ertd594e	0.66	NM_133791.3
2900008M13Rik	0.63	XM_110121
2010300G19Rik	0.61	NM_028097.2
BC049975	0.59	XM_138237.2
9030611O19Rik	0.57	NM_027828.2

Fold change: ratio Scl^Δ/Δ MkPs/WT MkP.

†

Specific functions in megakaryopoiesis and/or platelet biology.

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