Patient and sample characteristics
| Patient . | Sex . | Heart defect . | Age at TX, y . | Age at blood draw, y . | Age at MRI, y (results)‡ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| T01* | m | TGA | 0.0 | 0.2 | ||||||
| T02 | m | HLHS | 0.0 | 0.3† | ||||||
| T03* | m | HRHS | 0.3 | 0.5† | 3.4 | 4.5† | ||||
| T04 | f | HLHS | 0.0 | 0.6 | 2.0† | |||||
| T05 | m | PA | 0.0 | 0.7† | ||||||
| T06 | m | CoA | 0.3 | 0.9 | ||||||
| T07 | m | TGA | 0.1 | 1.0 | ||||||
| T08* | f | PA | 0.0 | 1.3 | ||||||
| T09 | m | TGA | 0.0 | 1.9† | ||||||
| T10* | m | TGA | 0.0 | 1.9 | ||||||
| T11 | m | TGA | 0.1 | 2.0 | ||||||
| T12 | f | HLHS | 0.0 | 2.0† | ||||||
| T13 | m | TGA | 0.0 | 2.1† | ||||||
| T14 | m | HLHS | 0.0 | 2.1† | ||||||
| T15* | m | TGA | 0.0 | 2.3 | ||||||
| T16 | f | HLHS | 0.0 | 2.4† | ||||||
| T17 | m | CoA | 0.1 | 2.5† | ||||||
| T18* | m | TGA | 0.1 | 2.9 | ||||||
| T19 | f | AoH | 0.0 | 3.6† | ||||||
| T20 | f | TvA | 0.6 | 6.7† | ||||||
| T21 | m | TGA | 0.0 | 7.6 | ||||||
| T22 | f | TGA | 0.0 | 8.0 | ||||||
| T23 | m | TvA | 0.1 | 8.6† | ||||||
| T24 | m | TGA | 0.0 | 10.4 | ||||||
| T25 | f | TGA | 0.0 | 10.7 | 10.6(−) | |||||
| T26 | m | TGA | 0.1 | 12.4† | ||||||
| T27 | m | TGA | 0.0 | 12.8 | ||||||
| T28 | m | TGA | 0.0 | 15.6 | ||||||
| T29 | m | TGA | 0.0 | 18.2 | 19.3(+) | |||||
| T30 | m | TGA | 0.0 | 18.6 | 3.9(s) | 7.7(s) | 16.5(+) | 18.2(+) | ||
| T31 | m | TGA | 0.2 | 20.7 | ||||||
| T32 | m | TGA | 0.0 | 21.8 | ||||||
| T33 | m | TGA | 0.0 | 23.1 | 18.9(+) | 21.6(+) | 22.9(+) | |||
| T34 | m | TGA | 0.0 | 23.9 | 19.7(−) | 22.3(−) | ||||
| T35 | m | TGA | 0.0 | 24.1 | ||||||
| T36 | f | TGA | 0.6 | 24.7 | 21.2(+) | |||||
| T37 | m | TGA | 0.6 | 25.1 | 22.3(+) | |||||
| T38 | f | TGA | 1.1 | 31.5 | 28.8(+) | |||||
| T39 | f | TGA | 1.5 | 32.9 | ||||||
| Patient . | Sex . | Heart defect . | Age at TX, y . | Age at blood draw, y . | Age at MRI, y (results)‡ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| T01* | m | TGA | 0.0 | 0.2 | ||||||
| T02 | m | HLHS | 0.0 | 0.3† | ||||||
| T03* | m | HRHS | 0.3 | 0.5† | 3.4 | 4.5† | ||||
| T04 | f | HLHS | 0.0 | 0.6 | 2.0† | |||||
| T05 | m | PA | 0.0 | 0.7† | ||||||
| T06 | m | CoA | 0.3 | 0.9 | ||||||
| T07 | m | TGA | 0.1 | 1.0 | ||||||
| T08* | f | PA | 0.0 | 1.3 | ||||||
| T09 | m | TGA | 0.0 | 1.9† | ||||||
| T10* | m | TGA | 0.0 | 1.9 | ||||||
| T11 | m | TGA | 0.1 | 2.0 | ||||||
| T12 | f | HLHS | 0.0 | 2.0† | ||||||
| T13 | m | TGA | 0.0 | 2.1† | ||||||
| T14 | m | HLHS | 0.0 | 2.1† | ||||||
| T15* | m | TGA | 0.0 | 2.3 | ||||||
| T16 | f | HLHS | 0.0 | 2.4† | ||||||
| T17 | m | CoA | 0.1 | 2.5† | ||||||
| T18* | m | TGA | 0.1 | 2.9 | ||||||
| T19 | f | AoH | 0.0 | 3.6† | ||||||
| T20 | f | TvA | 0.6 | 6.7† | ||||||
| T21 | m | TGA | 0.0 | 7.6 | ||||||
| T22 | f | TGA | 0.0 | 8.0 | ||||||
| T23 | m | TvA | 0.1 | 8.6† | ||||||
| T24 | m | TGA | 0.0 | 10.4 | ||||||
| T25 | f | TGA | 0.0 | 10.7 | 10.6(−) | |||||
| T26 | m | TGA | 0.1 | 12.4† | ||||||
| T27 | m | TGA | 0.0 | 12.8 | ||||||
| T28 | m | TGA | 0.0 | 15.6 | ||||||
| T29 | m | TGA | 0.0 | 18.2 | 19.3(+) | |||||
| T30 | m | TGA | 0.0 | 18.6 | 3.9(s) | 7.7(s) | 16.5(+) | 18.2(+) | ||
| T31 | m | TGA | 0.2 | 20.7 | ||||||
| T32 | m | TGA | 0.0 | 21.8 | ||||||
| T33 | m | TGA | 0.0 | 23.1 | 18.9(+) | 21.6(+) | 22.9(+) | |||
| T34 | m | TGA | 0.0 | 23.9 | 19.7(−) | 22.3(−) | ||||
| T35 | m | TGA | 0.0 | 24.1 | ||||||
| T36 | f | TGA | 0.6 | 24.7 | 21.2(+) | |||||
| T37 | m | TGA | 0.6 | 25.1 | 22.3(+) | |||||
| T38 | f | TGA | 1.1 | 31.5 | 28.8(+) | |||||
| T39 | f | TGA | 1.5 | 32.9 | ||||||
HLHS indicates hypoplastic left heart syndrome; HRHS, hypoplastic right heart syndrome; PA, pulmonary atresia; CoA, aortic coarctation; AoH, aortic hypoplasia; TvA, tricuspid valve atresia; and TX, thymectomy.
Patients for whom a sample was collected prior to thymectomy.
Samples collected just prior to a secondary operation. During none of these operations could thymic tissue be observed macroscopically.
For MRI results, (−) indicates no thymic tissue on MRI; (s), thymus visible on MRI, but small for the age of the individual; and (+), thymus visible on MRI and normal for the age of the individual.