REG3α concentrations and characteristics at onset of GVHD diarrhea predict 4-week response to GVHD therapy and 1-year NRM
| . | Independent . | Simultaneous . | ||
|---|---|---|---|---|
| Ratio . | P* . | Ratio . | P* . | |
| No response to treatment (at 4 wk) | Odds | Odds | ||
| REG3α (high vs low) | 4.8 | < .001 | 5.7 | .001 |
| GVHD GI onset stage (2-4 vs 1) | 3.9 | .001 | 3.0 | .027 |
| Histologic grade (4 vs 1-3) | 18.9 | < .001 | 16.7 | < .001 |
| Albumin (low vs high) | 2.5 | .02 | 1.4 | .5 |
| 1-y NRM | Hazard | Hazard | ||
| REG3α (high vs low) | 2.2 | .003 | 2.4 | .002 |
| GVHD GI onset stage (2-4 vs 1) | 3.0 | < .001 | 3.1 | < .001 |
| Histologic grade (4 vs 1-3) | 3.6 | < .001 | 2.9 | < .001 |
| Albumin (low vs high) | 2.3 | .004 | 1.6 | .2 |
| . | Independent . | Simultaneous . | ||
|---|---|---|---|---|
| Ratio . | P* . | Ratio . | P* . | |
| No response to treatment (at 4 wk) | Odds | Odds | ||
| REG3α (high vs low) | 4.8 | < .001 | 5.7 | .001 |
| GVHD GI onset stage (2-4 vs 1) | 3.9 | .001 | 3.0 | .027 |
| Histologic grade (4 vs 1-3) | 18.9 | < .001 | 16.7 | < .001 |
| Albumin (low vs high) | 2.5 | .02 | 1.4 | .5 |
| 1-y NRM | Hazard | Hazard | ||
| REG3α (high vs low) | 2.2 | .003 | 2.4 | .002 |
| GVHD GI onset stage (2-4 vs 1) | 3.0 | < .001 | 3.1 | < .001 |
| Histologic grade (4 vs 1-3) | 3.6 | < .001 | 2.9 | < .001 |
| Albumin (low vs high) | 2.3 | .004 | 1.6 | .2 |
NRM indicates nonrelapse mortality; and GI, gastrointestinal.
Adjusted for age, donor type, HLA match, conditioning intensity, and disease status at transplantation.