Autoimmunity associated with cancer vaccines
| Vaccine . | Malignancy (species) . | Autoimmune events . | Reference(s) . |
|---|---|---|---|
| TRP-1 encoded by virus | Melanoma (mouse) | Vitiligo | 120,121 |
| CD20 + adjuvant | Lymphoma (mouse) | Depletion of normal B cells | 122 |
| Her-2 encoded by plasmids | Breast cancer–expressing Her-2 (mouse) | Impaired lactation, accelerated involution of mammary gland | 123,124 |
| DCs (peptide pulsed) CD40 and IL-2 (fibroblasts) | Lymphoblastic leukemia (mouse) | Systemic autoimmunity, immunity against fibroblasts, hepatomegaly, splenomegaly, fur loss, cachexia, | 125 |
| DCs (peptide-pulsed) β-gal and LCMV model antigens | EL-4 thymoma (mouse) | Diabetes, myocarditis | 126 |
| Pulsed DCs or tumor cells and either GM-CSF and adjuvant or GM-CSF, adjuvant, and peptides | Melanoma (human) | Vitiligo, diabetes, thyroiditis, ocular toxicity | 69 |
| Vaccine . | Malignancy (species) . | Autoimmune events . | Reference(s) . |
|---|---|---|---|
| TRP-1 encoded by virus | Melanoma (mouse) | Vitiligo | 120,121 |
| CD20 + adjuvant | Lymphoma (mouse) | Depletion of normal B cells | 122 |
| Her-2 encoded by plasmids | Breast cancer–expressing Her-2 (mouse) | Impaired lactation, accelerated involution of mammary gland | 123,124 |
| DCs (peptide pulsed) CD40 and IL-2 (fibroblasts) | Lymphoblastic leukemia (mouse) | Systemic autoimmunity, immunity against fibroblasts, hepatomegaly, splenomegaly, fur loss, cachexia, | 125 |
| DCs (peptide-pulsed) β-gal and LCMV model antigens | EL-4 thymoma (mouse) | Diabetes, myocarditis | 126 |
| Pulsed DCs or tumor cells and either GM-CSF and adjuvant or GM-CSF, adjuvant, and peptides | Melanoma (human) | Vitiligo, diabetes, thyroiditis, ocular toxicity | 69 |
DCs indicates dendritic cells; LCMV, lymphocytic choriomeningitis virus; and GM-CSF, granulocyte-macrophage colony-stimulating factor.