Cell-cycle and IFN-regulated genes are up-regulated in Irgm1 HSCs
| Cell-cycle genes . | IFN-associated genes . | ||
|---|---|---|---|
| Gene symbol . | Fold-change . | Gene symbol . | Fold-change . |
| Spag5 | 5.8 | Ccl5 | 30.5 |
| Ncapg | 4.4 | Ifit1 | 17.1 |
| Rrm2 | 4.3 | Cxcl10 | 14.7 |
| Ccnb2 | 4.1 | Lilrb4 | 13.5 |
| Ccna2 | 3.9 | Rsad2 | 12.3 |
| Aurkb | 3.6 | Cxcl9 | 8.5 |
| Nupr1 | 3.4 | Usp18 | 7.9 |
| Nek2 | 3.4 | Oasl1 | 7.6 |
| Kif20a | 3.3 | Ifi27 | 6.9 |
| Tk1 | 3.3 | Cxcl11 | 5.5 |
| Dtl | 3.2 | Ifit3 | 5.1 |
| Ccnb1-rs1 | 3.2 | LOC623121 | 5.1 |
| Cdca3 | 3.1 | Irf7 | 4.6 |
| Ccnb1 | 3.1 | Selp | 4.6 |
| Id3 | 3.0 | Oas2 | 3.5 |
| Gins1 | 3.0 | Ifit2 | 3.4 |
| Ube2c | 3.0 | Fas | 3.4 |
| Stil | 2.9 | Mki67 | 3.3 |
| Id2 | 2.9 | Irga6 | 2.8 |
| Bub1 | 2.8 | ||
| Cell-cycle genes . | IFN-associated genes . | ||
|---|---|---|---|
| Gene symbol . | Fold-change . | Gene symbol . | Fold-change . |
| Spag5 | 5.8 | Ccl5 | 30.5 |
| Ncapg | 4.4 | Ifit1 | 17.1 |
| Rrm2 | 4.3 | Cxcl10 | 14.7 |
| Ccnb2 | 4.1 | Lilrb4 | 13.5 |
| Ccna2 | 3.9 | Rsad2 | 12.3 |
| Aurkb | 3.6 | Cxcl9 | 8.5 |
| Nupr1 | 3.4 | Usp18 | 7.9 |
| Nek2 | 3.4 | Oasl1 | 7.6 |
| Kif20a | 3.3 | Ifi27 | 6.9 |
| Tk1 | 3.3 | Cxcl11 | 5.5 |
| Dtl | 3.2 | Ifit3 | 5.1 |
| Ccnb1-rs1 | 3.2 | LOC623121 | 5.1 |
| Cdca3 | 3.1 | Irf7 | 4.6 |
| Ccnb1 | 3.1 | Selp | 4.6 |
| Id3 | 3.0 | Oas2 | 3.5 |
| Gins1 | 3.0 | Ifit2 | 3.4 |
| Ube2c | 3.0 | Fas | 3.4 |
| Stil | 2.9 | Mki67 | 3.3 |
| Id2 | 2.9 | Irga6 | 2.8 |
| Bub1 | 2.8 | ||
The list of genes differentially expressed in Irgm1−/− HSCs (SPL; filtered on a fold difference of 21.5) in microarrays was manually annotated. Twenty cell-cycle genes and 19 IFN-regulated genes were found to be up-regulated in KO HSCs. These genes are listed here, along with the -fold difference between KO and WT cells.
KO indicates knockout; and WT, wild-type.