Factors to consider in the clinical decision making for frail patients with MM
| Factors . | Aim . |
|---|---|
| Age | To assess frailty |
| GA | |
| CRAB criteria | To start treatment |
| Hypercalcemia | |
| Renal failure | |
| Anemia | |
| Bone lesions | |
| Biomarkers of malignancy | |
| Clonal bone marrow plasma cell percentage ≥60% | |
| Involved/uninvolved serum free light-chain ratio ≥100 | |
| >1 focal lesion (≥5 mm) on MRI studies | |
| Cardiovascular history | To choose treatment |
| History of diabetes | |
| Renal function | |
| Neuropathy | |
| Psychosocial status | |
| Preferences of the patient and the caregiver |
| Factors . | Aim . |
|---|---|
| Age | To assess frailty |
| GA | |
| CRAB criteria | To start treatment |
| Hypercalcemia | |
| Renal failure | |
| Anemia | |
| Bone lesions | |
| Biomarkers of malignancy | |
| Clonal bone marrow plasma cell percentage ≥60% | |
| Involved/uninvolved serum free light-chain ratio ≥100 | |
| >1 focal lesion (≥5 mm) on MRI studies | |
| Cardiovascular history | To choose treatment |
| History of diabetes | |
| Renal function | |
| Neuropathy | |
| Psychosocial status | |
| Preferences of the patient and the caregiver |
MRI, magnetic resonance imaging.