Table 1 Validation of gene expression... | American Society of Hematology

Table 1

Validation of gene expression changes by quantitative RT-PCR

Gene	Analysis list*	Test
t test		(E,L)
FANCD2	Diagnosis vs relapse	0.011
FOXM1	Diagnosis vs relapse	0.002
HRK	Diagnosis vs relapse	0.590
CENPM	Diagnosis vs relapse	0.017
SMEK2	Diagnosis vs relapse	0.140
IFIT5	Diagnosis vs relapse	0.110
LAPTM4B	Diagnosis vs relapse	0.280
OBSL1	Diagnosis vs relapse	0.002
CCNB2	Early relapse	0.055, 0.089
KCNH2	Early relapse	0.013, 0.065
TYMS	Late relapse	0.140, 0.028
ATIC	Late relapse	0.028, 0.009
CAD	Late relapse	0.051, 0.035
GART	Late relapse	0.062, 0.034
PAICS	Late relapse	0.037, 0.013
IMPA2	Late relapse	0.030, 0.001
RAD51AP1	Late relapse	0.100, 0.002
BIRC5	Early and late relapse	0.005
BUB1B	Early and late relapse	0.018
Wilcoxon test†
WT1	M/E	0.05
GATA5	M/E	0.05
CSMD1	M/E	0.05
COL6A	M/E	0.05
CDKN2A	M/E	0.05
TOP1MT	M/E	> 0.05
NOTCH4	M/E	> 0.05

Gene	Analysis list*	Test
t test		(E,L)
FANCD2	Diagnosis vs relapse	0.011
FOXM1	Diagnosis vs relapse	0.002
HRK	Diagnosis vs relapse	0.590
CENPM	Diagnosis vs relapse	0.017
SMEK2	Diagnosis vs relapse	0.140
IFIT5	Diagnosis vs relapse	0.110
LAPTM4B	Diagnosis vs relapse	0.280
OBSL1	Diagnosis vs relapse	0.002
CCNB2	Early relapse	0.055, 0.089
KCNH2	Early relapse	0.013, 0.065
TYMS	Late relapse	0.140, 0.028
ATIC	Late relapse	0.028, 0.009
CAD	Late relapse	0.051, 0.035
GART	Late relapse	0.062, 0.034
PAICS	Late relapse	0.037, 0.013
IMPA2	Late relapse	0.030, 0.001
RAD51AP1	Late relapse	0.100, 0.002
BIRC5	Early and late relapse	0.005
BUB1B	Early and late relapse	0.018
Wilcoxon test†
WT1	M/E	0.05
GATA5	M/E	0.05
CSMD1	M/E	0.05
COL6A	M/E	0.05
CDKN2A	M/E	0.05
TOP1MT	M/E	> 0.05
NOTCH4	M/E	> 0.05

E,L indicates diagnosis vs early relapse, diagnosis vs late relapse; and M/E, correlation of methylation and gene expression.

All comparisons are from diagnosis to relapse.

Wilcoxon paired signed-rank test.